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Fitzgerald, Katherine
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Endowed Chair Honorary Title Worcester Foundation for Biomedical Research Chair III
overview

Biography

Dr. Fitzgerald is Professor and Vice Chair of Medicine, Chief of the Division of Innate Immunity, and the Worcester Foundation in Biomedical Sciences Research Chair. Dr. Fitzgerald completed all of her education in Ireland. She received her B.Sc. in Biochemistry in 1995 from University College Cork, Ireland and her PhD in Biochemistry in 1999 from Trinity College Dublin, Ireland. After pursing a post-doctoral fellowship at Trinity College Dublin, she joined UMass Chan as Instructor and is currently a tenured Professor.

Dr. Fitzgerald is an elected fellow of the American Society of Microbiology and an elected member of the Royal Irish Academy, the National Academy of Sciences (USA) and the National Academy of Medicine (USA). She is the recipient of several awards including the  Thermo-Fischer Meritorious Career Award (from the American Association of Immunology), the Saint Patrick’s Day Medal (from the Irish Government and Science Foundation Ireland) and the Milstein Award for Excellence in Interferon and Cytokine research (from the International Cytokine and Interferon Society), amongst others.

She has extensive service both locally at UMass Chan and nationally including service on local and national advisory boards (e.g., Massachusetts Center For Pathogen Readiness, NIAID Board of Scientific Councillors, Burroughs Wellcome Fund Pathogenesis of Infectious Diseases and the Cancer Research Institute). She was also the recent past President of the International Cytokine and Interferon Society.

Research Information  Katherine PhotoHer work is focused on the innate immune system aimed at understanding the molecular basis of the inflammatory response during Infection and in inflammatory diseases. In particular her group studies nucleic acid sensors, inflammasomes as well as long non-coding RNAs in immunity and inflammation. The long-term goal of her work is to determine how innate immune sensing and signaling contribute to infectious, inflammatory, and autoimmune diseases in humans.

 
One or more keywords matched the following items that are connected to Fitzgerald, Katherine
Item TypeName
Academic Article Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
Academic Article Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.
Academic Article IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Academic Article Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
Academic Article DUBbing down innate immunity.
Academic Article The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
Academic Article The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
Academic Article TOLLing away in Brazil.
Academic Article The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence.
Academic Article Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
Academic Article Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Academic Article Immunology. The shape of things to come.
Academic Article TLR-mediated activation of type I IFN during antiviral immune responses: fighting the battle to win the war.
Academic Article Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance.
Academic Article The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Academic Article Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Academic Article Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination.
Academic Article Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Academic Article Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.
Academic Article A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.
Academic Article TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
Academic Article Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
Academic Article Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
Academic Article An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans.
Academic Article A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
Academic Article NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.
Academic Article Integr-ating IL-1 alpha in antiviral host defenses.
Academic Article A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
Academic Article Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.
Academic Article IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway.
Academic Article Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling.
Academic Article Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3).
Academic Article TLR4 is a negative regulator in noninfectious lung inflammation.
Academic Article Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome.
Academic Article Pattern recognition receptors: an update.
Academic Article Catenin' on to nucleic acid sensing.
Academic Article Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus.
Academic Article Inflammasomes and anti-viral immunity.
Academic Article Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
Academic Article Pattern recognition receptors and the innate immune response to viral infection.
Academic Article A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans.
Academic Article Activation of autophagy by inflammatory signals limits IL-1? production by targeting ubiquitinated inflammasomes for destruction.
Academic Article Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
Academic Article Cytosolic surveillance and antiviral immunity.
Academic Article Immunology. Select inflammasome assembly.
Academic Article DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
Academic Article Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
Academic Article Serine/threonine acetylation of TGF?-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.
Academic Article TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
Academic Article Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
Academic Article Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?.
Academic Article Molecular basis of DNA recognition in the immune system.
Academic Article SnapShot: inflammasomes.
Academic Article The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Academic Article Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
Academic Article CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Academic Article A long noncoding RNA mediates both activation and repression of immune response genes.
Academic Article The Toll-IL-1 receptor adaptor family grows to five members.
Academic Article LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
Academic Article Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex.
Academic Article IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
Academic Article TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Academic Article Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.
Academic Article TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression.
Academic Article Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.
Academic Article The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
Academic Article Endotoxin recognition and signal transduction by the TLR4/MD2-complex.
Academic Article Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence.
Academic Article Interferon gene regulation: not all roads lead to Tolls.
Academic Article Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion.
Academic Article Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.
Academic Article Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex.
Academic Article The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Academic Article Sorting out Toll signals.
Academic Article Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
Academic Article Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.
Academic Article RIG-I: tri-ing to discriminate between self and non-self RNA.
Academic Article NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Academic Article Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.
Academic Article The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
Academic Article AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Academic Article Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Academic Article Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Academic Article Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
Academic Article Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.
Academic Article Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
Academic Article The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Academic Article NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Academic Article Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
Academic Article Viral defense: it takes two MAVS to Tango.
Academic Article Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.
Academic Article Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.
Academic Article Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
Academic Article Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-? and RANTES production.
Academic Article Recognition of herpesviruses by the innate immune system.
Academic Article Innate immune sensing of DNA viruses.
Academic Article Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM.
Academic Article Innate immune sensing of DNA.
Academic Article Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein.
Academic Article Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract.
Academic Article Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice.
Academic Article Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Academic Article Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway.
Academic Article The PYHIN protein family as mediators of host defenses.
Academic Article Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16.
Academic Article Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Academic Article The NLRP12 inflammasome recognizes Yersinia pestis.
Academic Article NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1? and neuronal toxicity.
Academic Article 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential.
Academic Article Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Academic Article Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Academic Article RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge.
Academic Article Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
Academic Article Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.
Academic Article Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.
Academic Article Immunology: Lipopolysaccharide sensing on the inside.
Academic Article An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein.
Academic Article The human T cell receptor: appearance in ontogeny and biochemical relationship of alpha and beta subunits on IL-2 dependent clones and T cell tumors.
Concept Cell Fusion
Concept Body Mass Index
Concept Metapneumovirus
Concept Epithelial Cells
Concept Protein Binding
Concept Yersinia
Concept Myxoma virus
Concept Receptors, Interleukin-1
Concept Staphylococcus aureus
Concept Anti-Bacterial Agents
Concept Gram-Positive Bacteria
Concept DNA-Binding Proteins
Concept Interferon-beta
Concept Mycobacterium tuberculosis
Concept Viruses
Concept Receptors, LDL
Concept Receptors, IgG
Concept Escherichia coli K12
Concept Humans
Concept Receptors, Antigen, T-Cell
Concept Wolbachia
Concept Plasmodium chabaudi
Concept Phosphate-Binding Proteins
Concept Brain
Concept Aged, 80 and over
Concept Gammaherpesvirinae
Concept Infant
Concept HeLa Cells
Concept Cell Nucleus
Concept E-Box Elements
Concept Drosophila melanogaster
Concept Caenorhabditis elegans
Concept Cell Communication
Concept Receptor, Interferon alpha-beta
Concept Plasmodium
Concept Rift Valley fever virus
Concept Mice, Inbred BALB C
Concept Prions
Concept Influenza A Virus, H1N1 Subtype
Concept Carcinoma, Basal Cell
Concept Cell Survival
Concept Receptors, Cell Surface
Concept Periplasmic Binding Proteins
Concept Dependovirus
Concept Toll-Like Receptors
Concept ral GTP-Binding Proteins
Concept Bone Marrow Transplantation
Concept GTP-Binding Proteins
Concept BALB 3T3 Cells
Concept Molecular Biology
Concept Animals
Concept Herpesvirus 1, Human
Concept Computer Simulation
Concept Biological Assay
Concept Mammals
Concept Aged
Concept Dendritic Cells
Concept Proto-Oncogene Proteins c-bcl-2
Concept Protein Biosynthesis
Concept Receptors, G-Protein-Coupled
Concept Mice, Knockout
Concept Endothelial Cells
Concept Mice, Inbred C3H
Concept Adolescent
Concept Blotting, Western
Concept Brugia malayi
Concept Butyrates
Concept Neisseria gonorrhoeae
Concept Streptococcus pneumoniae
Concept Receptors, Pattern Recognition
Concept Klebsiella
Concept Tumor Cells, Cultured
Concept Integrin beta3
Concept Citrobacter rodentium
Concept Biomarkers
Concept Poxviridae
Concept Xenopus
Concept RNA, Bacterial
Concept BH3 Interacting Domain Death Agonist Protein
Concept Child, Preschool
Concept Mice
Concept Cell Differentiation
Concept Bone Marrow Cells
Concept Models, Biological
Concept Biological Transport, Active
Concept Receptors, Tumor Necrosis Factor, Type II
Concept beta Carotene
Concept Biotransformation
Concept Herpesviridae
Concept rab GTP-Binding Proteins
Concept Dengue Virus
Concept CCAAT-Enhancer-Binding Protein-beta
Concept Adult
Concept Mice, Inbred C57BL
Concept Cell Polarity
Concept Bronchoalveolar Lavage Fluid
Concept Child
Concept Cell Movement
Concept Plasmodium vivax
Concept Cells, Cultured
Concept Pneumonia, Bacterial
Concept Mice, Transgenic
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept DNA Viruses
Concept Wuchereria
Concept Drosophila
Concept Bile Acids and Salts
Concept Cell Proliferation
Concept Bacteriolysis
Concept Hematopoietic Stem Cells
Concept DNA, Bacterial
Concept Escherichia coli
Concept Brazil
Concept Receptors, Antigen
Concept RNA Viruses
Concept Bone Marrow
Concept Enteropathogenic Escherichia coli
Concept DEAD-box RNA Helicases
Concept Cell Death
Concept Active Transport, Cell Nucleus
Concept Vesicular stomatitis Indiana virus
Concept Vero Cells
Concept Vaccinia virus
Concept Trypanosoma cruzi
Concept Candida albicans
Concept Paracoccidioides
Concept Cell Membrane
Concept ATP-Binding Cassette Transporters
Concept Bacterial Proteins
Concept Sheep
Concept Onchocerca volvulus
Concept Calcium-Binding Proteins
Concept Clone Cells
Concept Receptors, Tumor Necrosis Factor, Type I
Concept Receptors, Cytokine
Concept Brucella abortus
Concept Biological Phenomena
Concept Th1 Cells
Concept Binding Sites
Concept Francisella tularensis
Concept Lymphocytic choriomeningitis virus
Concept Adenoviridae
Concept CCAAT-Enhancer-Binding Proteins
Concept DNA Breaks, Double-Stranded
Concept Francisella
Concept Antigen-Presenting Cells
Concept Rats
Concept Receptors, Immunologic
Concept Autoimmunity
Concept Gram-Negative Bacterial Infections
Concept Listeria
Concept Receptors, Interleukin
Concept Stromal Cells
Concept Inflammatory Bowel Diseases
Concept Th2 Cells
Concept Embryonic Stem Cells
Concept Cell Membrane Permeability
Concept Encephalomyocarditis virus
Concept Rats, Wistar
Concept Bacterial Infections
Concept Cell Line
Concept B-Lymphocytes
Concept Influenza A virus
Concept Middle Aged
Concept Plasmodium falciparum
Concept Sendai virus
Concept Bacteria
Concept Chlamydophila pneumoniae
Concept beta-Glucans
Concept Receptors, Tumor Necrosis Factor
Concept Genetic Vectors
Concept Yersinia pestis
Concept Young Adult
Concept Whole-Body Irradiation
Concept Streptococcus agalactiae
Concept Myeloid Cells
Concept Base Sequence
Concept Killer Cells, Natural
Concept Amyloid beta-Peptides
Concept Salmonella typhimurium
Concept Listeria monocytogenes
Concept Mice, Mutant Strains
Concept Cell Line, Tumor
Concept Radiation Chimera
Concept Enterohemorrhagic Escherichia coli
Concept Gram-Negative Bacteria
Concept Receptors, Cytoplasmic and Nuclear
Concept RNA-Binding Proteins
Award or Honor Receipt BD-Investigator Award
Academic Article Long noncoding RNAs in innate and adaptive immunity.
Academic Article The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.
Academic Article Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation.
Academic Article Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-? and AIM2 inflammasome-dependent IL-1? production via its ESX-1 secretion system.
Academic Article Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.
Academic Article Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
Academic Article Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production.
Academic Article Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity.
Academic Article Recognition of cytosolic DNA by cGAS and other STING-dependent sensors.
Academic Article Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
Academic Article Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals.
Academic Article Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Academic Article Rift Valley fever virus infection induces activation of the NLRP3 inflammasome.
Academic Article Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Academic Article TRIF signaling is essential for TLR4-driven IgE class switching.
Academic Article NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.
Academic Article Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.
Academic Article Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
Academic Article Post-transcriptional regulation of gene expression in innate immunity.
Academic Article Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome.
Academic Article TRIM13 is a negative regulator of MDA5-mediated type I interferon production.
Academic Article 3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1? interferes with mature IL-1? signaling.
Academic Article RNA and ?-hemolysin of group B Streptococcus induce interleukin-1? (IL-1?) by activating NLRP3 inflammasomes in mouse macrophages.
Academic Article TRIL is involved in cytokine production in the brain following Escherichia coli infection.
Academic Article Citrobacter rodentium: infection, inflammation and the microbiota.
Academic Article Interferon ?-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses.
Academic Article Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1? production in response to ?-glucans and the fungal pathogen, Candida albicans.
Academic Article IKKa negatively regulates ASC-dependent inflammasome activation.
Academic Article STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Academic Article Identification of Aim2 as a sensor for DNA vaccines.
Academic Article Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.
Academic Article Transcription of inflammatory genes: long noncoding RNA and beyond.
Academic Article A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
Academic Article Suppression of systemic autoimmunity by the innate immune adaptor STING.
Academic Article Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin.
Academic Article GBPs take AIM at Francisella.
Academic Article Paula Pitha-Rowe 1937-2015.
Academic Article Mechanisms of inflammasome activation: recent advances and novel insights.
Academic Article Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease.
Academic Article Cutting Edge: A Natural Antisense Transcript, AS-IL1a, Controls Inducible Transcription of the Proinflammatory Cytokine IL-1a.
Academic Article Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.
Academic Article An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual.
Academic Article Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation.
Academic Article Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.
Academic Article Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2.
Academic Article A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines.
Academic Article Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.
Academic Article Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression.
Academic Article IMMUNOLOGY. An RNA twist to T(H)17 cells.
Academic Article The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.
Academic Article Inflammasome Complexes: Emerging Mechanisms and Effector Functions.
Academic Article Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.
Academic Article A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.
Academic Article A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In?Vivo Infection.
Academic Article Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production.
Academic Article Control of the innate immune response by the mevalonate pathway.
Academic Article Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production.
Academic Article Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity.
Academic Article Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?
Academic Article Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.
Academic Article miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).
Academic Article Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-? Synthesis Induced by Lipopolysaccharide.
Academic Article The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.
Academic Article Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria.
Academic Article IRF3 and type I interferons fuel a fatal response to myocardial infarction.
Academic Article Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.
Academic Article Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis.
Academic Article Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.
Academic Article The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.
Academic Article Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Academic Article A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1? Release in Response to a Pathogenic Fungus.
Academic Article Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.
Academic Article CNBP controls IL-12 gene transcription and Th1 immunity.
Academic Article Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS.
Academic Article Cytokines and Long Noncoding RNAs.
Academic Article cGAS Micro-Manages Genotoxic Stress.
Academic Article Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.
Academic Article Immature lung TNFR2- conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo.
Academic Article cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Academic Article HiChIRP reveals RNA-associated chromosome conformation.
Academic Article Activation of Stimulator of Interferon Genes (STING) and Sj?gren Syndrome.
Academic Article Gasdermins and their role in immunity and inflammation.
Academic Article hnRNPA2B1: Fueling Antiviral Immunity from the Nucleus.
Academic Article A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome.
Academic Article Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection.
Academic Article Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.
Academic Article Toll-like Receptors and the Control of Immunity.
Academic Article Long non-coding RNAs in antiviral immunity.
Academic Article STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
Academic Article TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge.
Academic Article Succination inactivates gasdermin D and blocks pyroptosis.
Academic Article Caspase-8 mediates inflammation and disease in rodent malaria.
Academic Article HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
Academic Article Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis.
Academic Article Loosening the grip on nuclear cGAS.
Academic Article The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans.
Academic Article Overcoming innate immune barriers that impede AAV gene therapy vectors.
Academic Article cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE.
Academic Article Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
Academic Article Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.
Academic Article AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.
Academic Article A genetic screen in macrophages identifies new regulators of IFN?-inducible MHCII that contribute to T cell activation.
Academic Article Apoptosis, Pyroptosis, and Necroptosis-Oh My! The Many Ways a Cell Can Die.
Concept DEAD Box Protein 58
Concept A549 Cells
Concept THP-1 Cells
Concept Positive Regulatory Domain I-Binding Factor 1
Concept Mice, 129 Strain
Concept HEK293 Cells
Concept Bacterial Secretion Systems
Concept DNA, B-Form
Concept Receptors, Purinergic P2X7
Concept Bacterial Load
Concept Th17 Cells
Concept B7-H1 Antigen
Concept Primary Cell Culture
Concept Microbiota
Academic Article Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
Academic Article Intracellular Sensing of DNA in Autoinflammation and Autoimmunity.
Academic Article Radioresistant cells initiate lymphocyte-dependent lung inflammation and IFN?-dependent mortality in STING gain-of-function mice.
Academic Article Regulation of Synovial ?d T Cell Ligand Expression by Mitochondrial Reactive Oxygen Species and Gasdermin-D.
Academic Article Hold your horses! Reining in your fastest pores with caspase-7.
Academic Article Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression.
Academic Article The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2.
Academic Article Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants.
Academic Article TBK1 inhibition unleashes RIPK1, resensitizing tumors to immunotherapy.
Academic Article MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection.
Academic Article Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Academic Article STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice.
Academic Article ERADication of STING limits inflammation.
Academic Article The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.
Academic Article Targeting STING oligomerization with small-molecule inhibitors.
Academic Article Development of LB244, an Irreversible STING Antagonist.
Academic Article Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer.
Academic Article STING channels its proton power.
Academic Article Differential Viral Dynamics by Sex and Body Mass Index During Acute SARS-CoV-2 Infection: Results From a Longitudinal Cohort Study.
Academic Article Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA-protein condensates.
Academic Article Lnc-ing RNA to intestinal homeostasis and inflammation.
Academic Article Gene coexpression networks reveal a broad role for lncRNAs in inflammatory bowel disease.
Academic Article Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells.
Academic Article The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection.
Academic Article Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration.
Academic Article Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer.
Academic Article DNA-sensing pathways in health, autoinflammatory and autoimmune diseases.
Academic Article Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system.
Academic Article Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.
Academic Article A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control.
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