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Shultz, Leonard
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Academic Article Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.
Academic Article Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells.
Academic Article Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients.
Academic Article Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.
Academic Article CD8+ T lymphocytes are not required for murine resistance to human filarial parasites.
Academic Article Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice.
Academic Article LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors.
Academic Article Characteristics of long-term human thyroid peroxidase autoantibody secretion in scid mice transplanted with lymphocytes from patients with autoimmune thyroiditis.
Academic Article Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras.
Academic Article SCID mouse models of human stem cell engraftment.
Academic Article HIV-1 infectivity of human T cells in a human/murine chimeric fetal thymic organ culture system.
Academic Article Animal models for immunodeficiency diseases.
Academic Article Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.
Academic Article Growth of the human filarial parasite Brugia malayi in mice lacking major histocompatibility complex class II antigen expression.
Academic Article Evaluation of monoclonal antibody-mediated anti-acute myeloid leukemia immunotherapy in a SCID/hu model.
Academic Article Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice.
Academic Article The plant lectin FRIL supports prolonged in vitro maintenance of quiescent human cord blood CD34(+)CD38(-/low)/SCID repopulating stem cells.
Academic Article Increased expression of mXBP-1 (TREB-5) in thymic B cells in New Zealand mice.
Academic Article Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay.
Academic Article Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice.
Academic Article The molecular bases of spontaneous immunological mutations in the mouse and their homologous human diseases.
Academic Article Preservation of functioning human thyroid "organoids" in the scid mouse. IV. In vivo selection of an intrathyroidal T cell receptor repertoire.
Academic Article Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice.
Academic Article Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Hu?t anomaly).
Academic Article Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice.
Academic Article The pathophysiological significance of nondesmoglein targets of pemphigus autoimmunity. Development of antibodies against keratinocyte cholinergic receptors in patients with pemphigus vulgaris and pemphigus foliaceus.
Academic Article Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Hu?t anomaly.
Academic Article Continuous infusion of endostatin inhibits differentiation, mobilization, and clonogenic potential of endothelial cell progenitors.
Academic Article Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
Academic Article Bombesin/gastrin-releasing peptide receptor: a potential target for antibody-mediated therapy of small cell lung cancer.
Academic Article Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleen.
Academic Article The soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro maintenance and proliferation of human CD34(+)CD38(-/low) cells capable of repopulating severe combined immunodeficiency mice.
Academic Article An assay for human hematopoietic stem cells based on transplantation into nonobese diabetic recombination activating gene-null perforin-null mice.
Academic Article The Tetratricopeptide repeat domain 7 gene is mutated in flaky skin mice: a model for psoriasis, autoimmunity, and anemia.
Academic Article Human cord blood--derived cells generate insulin-producing cells in vivo.
Academic Article NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Academic Article Humanized mice: are we there yet?
Academic Article Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion.
Academic Article Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytes.
Academic Article Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice.
Academic Article Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi.
Academic Article beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function.
Academic Article Lanceolate hair-J (lahJ): a mouse model for human hair disorders.
Academic Article Inherited mouse mutations as models of human adnexal, cornification, and papulosquamous dermatoses.
Academic Article Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions.
Academic Article Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.
Academic Article Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome: a reappraisal of paraneoplastic pemphigus.
Academic Article Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.
Academic Article The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways.
Academic Article The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice.
Academic Article Creation of "humanized" mice to study human immunity.
Academic Article In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties.
Academic Article Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Academic Article Cancer stem cells are enriched in the side population cells in a mouse model of glioma.
Academic Article Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice.
Academic Article Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.
Academic Article Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
Academic Article Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
Academic Article In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase.
Academic Article Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
Academic Article Humanized mouse models to study human diseases.
Academic Article Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent.
Academic Article Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate.
Academic Article Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.
Academic Article Zoledronic acid potentiates mTOR inhibition and abolishes the resistance of osteosarcoma cells to RAD001 (Everolimus): pivotal role of the prenylation process.
Academic Article Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model.
Academic Article Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis.
Academic Article Humanized mouse models of HIV-1 latency.
Academic Article Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF.
Academic Article Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.
Academic Article Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody.
Academic Article Human allograft rejection in humanized mice: a historical perspective.
Academic Article Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
Academic Article Antibody repertoires in humanized NOD-scid-IL2R?(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse.
Academic Article Humanized mouse model used to monitor MUC gene expression in nasal polyps and to preclinically evaluate the efficacy of montelukast in reducing mucus production.
Academic Article In vitro and in vivo hematopoietic potential of human stem cells residing in muscle tissue.
Academic Article Humanized mice for immune system investigation: progress, promise and challenges.
Academic Article GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation.
Academic Article A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.
Academic Article The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.
Academic Article Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model.
Academic Article Mouse models of genetic diseases.
Academic Article Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells.
Academic Article Hematopoiesis and models of immunodeficiency.
Academic Article Evaluation of the mouse mutant "wasted" as an animal model for ataxia telangiectasia. I. Age-dependent and tissue-specific effects.
Academic Article Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.
Academic Article NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.
Academic Article Hairpatches, a single gene mutation characterized by progressive renal disease and alopecia in the mouse. A potential model for a newly described heritable human disorder.
Academic Article Evaluations of wasted mouse fibroblasts and SV-40 transformed human fibroblasts as models of ataxia telangiectasia in vitro.
Academic Article Transgenic mice expressing either bovine growth hormone (bGH) or human GH releasing hormone (hGRH) have increased splenic progenitor cell colony formation and DNA synthesis in vitro and in vivo.
Academic Article High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
Academic Article Graves' disease thyroid tissue transplants in scid mice: persistent selectivity in hTcR Va gene family use.
Academic Article Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.
Academic Article Human bone marrow and umbilical cord blood cells generate CD4+ and CD8+ single-positive T cells in murine fetal thymus organ culture.
Academic Article CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Academic Article Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
Academic Article Engraftment of human lymphocytes and thyroid tissue into scid and rag2-deficient mice: absent progression of lymphocytic infiltration.
Academic Article Preservation of functioning human thyroid "organoids" in the severe combined immunodeficient mouse. III. Thyrotropin independence of thyroid follicle formation.
Academic Article Preservation of functioning human thyroid organoids in the scid mouse: 1. System characterization.
Academic Article Preservation of functioning human thyroid organoids in the scid mouse: II. Biased use of intrathyroidal T cell receptor V genes.
Academic Article The inner nuclear membrane protein lamin B receptor forms distinct microdomains and links epigenetically marked chromatin to the nuclear envelope.
Academic Article Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
Academic Article Human cord blood- and bone marrow-derived CD34+ cells regenerate gastrointestinal epithelial cells.
Academic Article Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Academic Article Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.
Academic Article Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/beta2-microglobulin(null) mice.
Academic Article The immunodeficient scid mouse as a model for human lymphatic filariasis.
Academic Article The SCID-hu mouse and thyroid autoimmunity: characterization of human thyroid autoantibody secretion.
Academic Article In vivo distribution of human adipose-derived mesenchymal stem cells in novel xenotransplantation models.
Academic Article Humanized mice in translational biomedical research.
Academic Article Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
Academic Article Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.
Academic Article A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Academic Article CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL.
Academic Article Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice.
Academic Article Humanized SCID mouse models for biomedical research.
Academic Article A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Academic Article Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.
Academic Article Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains.
Academic Article T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.
Academic Article Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.
Academic Article Humanized mice for the study of type 1 diabetes and beta cell function.
Academic Article The mouse mutant "wasted": an animal model for ataxia-telangiectasia.
Academic Article Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.
Academic Article Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells.
Academic Article The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia.
Academic Article Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
Academic Article Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production.
Academic Article Human nasal polyp microenvironments maintained in a viable and functional state as xenografts in NOD-scid IL2rgamma(null) mice.
Academic Article NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.
Academic Article Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML.
Academic Article Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells.
Academic Article Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.
Academic Article Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.
Academic Article High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias.
Academic Article HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/?c(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.
Academic Article Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
Academic Article Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids.
Academic Article Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2r?(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease.
Academic Article Humanized mice as a preclinical tool for infectious disease and biomedical research.
Academic Article Humanized mice for the study of type 1 and type 2 diabetes.
Academic Article Ex?vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2R?(null) mice.
Academic Article Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
Academic Article Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice.
Academic Article Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo.
Academic Article Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
Academic Article Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-?-catenin signaling.
Academic Article Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.
Academic Article Humanized mice for the study of infectious diseases.
Academic Article A new in vivo screening paradigm to accelerate antimalarial drug discovery.
Academic Article Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice.
Academic Article Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols.
Academic Article Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes.
Academic Article B lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Academic Article Ultrastructure of macrophages and dendritic cells in osteopetrosis (op) mutant mice lacking macrophage colony-stimulating factor (M-CSF/CSF-1) activity.
Concept Humans
Concept Chromosomes, Human, Pair 17
Concept Chromosomes, Human
Concept tat Gene Products, Human Immunodeficiency Virus
Concept Herpesvirus 4, Human
Concept Chromosomes, Human, Pair 15
Concept Chromosomes, Human, Pair 1
Concept Enterovirus B, Human
Academic Article Regulated splicing of the a6 integrin cytoplasmic domain determines the fate of breast cancer stem cells.
Academic Article Overcoming current limitations in humanized mouse research.
Academic Article Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach.
Academic Article Novel neuroprotective GSK-3? inhibitor restricts Tat-mediated HIV-1 replication.
Academic Article Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice.
Academic Article Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2r?(null) mice treated with alogliptin.
Academic Article c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
Academic Article NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.
Academic Article Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.
Academic Article Subcapsular transplantation of tissue in the kidney.
Academic Article Human cancer growth and therapy in immunodeficient mouse models.
Academic Article Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development.
Academic Article Viral infection of engrafted human islets leads to diabetes.
Academic Article A laminin 511 matrix is regulated by TAZ and functions as the ligand for the a6B?1 integrin to sustain breast cancer stem cells.
Academic Article Generation of improved humanized mouse models for human infectious diseases.
Academic Article Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma.
Academic Article Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice.
Academic Article Generation of ? cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.
Academic Article Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia.
Academic Article MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.
Academic Article Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.
Academic Article IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG.
Academic Article Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.
Academic Article Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
Academic Article Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.
Academic Article P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.
Academic Article Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?.
Academic Article Humanized Mouse Models for Transplant Immunology.
Academic Article Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.
Academic Article Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice.
Academic Article Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.
Academic Article Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.
Academic Article Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.
Academic Article Genetically modified human CD4(+) T cells can be evaluated in?vivo without lethal graft-versus-host disease.
Academic Article A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours.
Academic Article Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.
Academic Article Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis.
Academic Article Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury.
Academic Article A novel animal model for bone metastasis in human lung cancer.
Academic Article Humanized Mouse Models of Clinical Disease.
Academic Article Improved B cell development in humanized NOD-scid IL2R?null mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3.
Academic Article Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice.
Academic Article Engraftment of Human Primary Acute Myeloid Leukemia Defined by Integrated Genetic Profiling in NOD/SCID/IL2r?null Mice for Preclinical Ceramide-Based Therapeutic Evaluation.
Academic Article Development of Humanized Mice in the Age of Genome Editing.
Academic Article mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.
Academic Article Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis.
Academic Article Age-dependent human ? cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.
Academic Article Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways.
Academic Article a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Academic Article Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice.
Academic Article Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
Academic Article Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy.
Academic Article RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?
Academic Article Genetic Models of Macrophage Depletion.
Academic Article Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic ? Cells for In?Vitro and In?Vivo Analysis.
Academic Article Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery.
Academic Article A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation.
Academic Article Human immune system development and survival of non-obese diabetic (NOD)-scid IL2r?(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.
Academic Article Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics.
Academic Article Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency.
Academic Article Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.
Academic Article Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model.
Academic Article Humanized mouse models of immunological diseases and precision medicine.
Academic Article Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice.
Academic Article Mesenchymal stem cells: From regeneration to cancer.
Academic Article Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.
Academic Article Humanized immune system mouse models: progress, challenges and opportunities.
Academic Article AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.
Academic Article Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features.
Academic Article Identification of a tumor-specific allo-HLA-restricted ?dTCR.
Academic Article Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells.
Academic Article Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain.
Academic Article Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.
Academic Article Tacrolimus- and sirolimus-induced human ? cell dysfunction is reversible and preventable.
Academic Article TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice.
Academic Article Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils.
Academic Article Dapagliflozin Does Not Directly Affect Human a or ? Cells.
Academic Article Innovations, challenges, and minimal information for standardization of humanized mice.
Academic Article Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice.
Academic Article Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status.
Academic Article Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis.
Academic Article Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia.
Academic Article A novel clinically relevant graft-versus-leukemia model in humanized mice.
Academic Article Role of MicroRNA in Inflammatory Bowel Disease: Clinical Evidence and the Development of Preclinical Animal Models.
Academic Article Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments.
Academic Article Circulating CD34+?cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice.
Academic Article Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia.
Academic Article Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15.
Academic Article Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment.
Academic Article Humanized mouse models for immuno-oncology research.
Academic Article NOD-scid IL2r?null mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.
Academic Article Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 Infection.
Academic Article Generation of the NeoThy mouse model for human immune system studies.
Academic Article Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.
Academic Article Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response.
Academic Article Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma.
Academic Article A human immune/muscle xenograft model of FSHD muscle pathology.
Academic Article Human IL-6 fosters long-term engraftment of patient derived disease-driving myeloma cells in immunodeficient mice.
Academic Article Nuclear factor kappa B-dependent persistence of Salmonella Typhi and Paratyphi in human macrophages.
Academic Article Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice.
Academic Article Human insulin as both antigen and protector in type 1 diabetes.
Academic Article Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Academic Article Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles.
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