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Shultz, Leonard

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Item Type	Name
Academic Article	CD4+ T cell activation and tolerance induction in B cell knockout mice.
Academic Article	Lack of peripherally induced tolerance to established skin allografts in immunologically reconstituted scid mice.
Academic Article	The murine thymic microenvironment: changes with age.
Academic Article	Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.
Academic Article	Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells.
Academic Article	The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.
Academic Article	Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.
Academic Article	Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.
Academic Article	Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice.
Academic Article	Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.
Academic Article	Role of tumor necrosis factor-alpha in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice.
Academic Article	Characteristics of long-term human thyroid peroxidase autoantibody secretion in scid mice transplanted with lymphocytes from patients with autoimmune thyroiditis.
Academic Article	Development and progression of psoriasiform dermatitis and systemic lesions in the flaky skin (fsn) mouse mutant.
Academic Article	Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice.
Academic Article	Abnormal development and differentiation of macrophages and dendritic cells in viable motheaten mutant mice deficient in haematopoietic cell phosphatase.
Academic Article	Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras.
Academic Article	Lymphadenopathy, elevated serum IgE levels, autoimmunity, and mast cell accumulation in flaky skin mutant mice.
Academic Article	Follicular dendritic cell (FDC) precursors in primary lymphoid tissues.
Academic Article	A comparative analysis of the murine thymic microenvironment in normal, autoimmune, and immunodeficiency states.
Academic Article	Effects of macrophage colony-stimulating factor on macrophages and their related cell populations in the osteopetrosis mouse defective in production of functional macrophage colony-stimulating factor protein.
Academic Article	Role of nitric oxide in host defense against an extracellular, metazoan parasite, Brugia malayi.
Academic Article	Animal models for immunodeficiency diseases.
Academic Article	Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation.
Academic Article	Thymic microenvironment and NZB mice: the abnormal thymic microenvironment of New Zealand mice correlates with immunopathology.
Academic Article	Tumorigenicity of green turtle fibropapilloma-derived fibroblast lines in immunodeficient mice.
Academic Article	NOD mice have a generalized defect in their response to transplantation tolerance induction.
Academic Article	NZB mice exhibit a primary T cell defect in fetal thymic organ culture.
Academic Article	Evaluation of monoclonal antibody-mediated anti-acute myeloid leukemia immunotherapy in a SCID/hu model.
Academic Article	B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.
Academic Article	Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice.
Academic Article	Critical roles for interleukin-4 and interleukin-5 during respiratory syncytial virus infection in the development of airway hyperresponsiveness after airway sensitization.
Academic Article	Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice.
Academic Article	Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice.
Academic Article	Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase.
Academic Article	Macrophage differentiation and expression of macrophage colony-stimulating factor in murine milky spots and omentum after macrophage elimination.
Academic Article	Thymic involution in viable motheaten (me(v)) mice is associated with a loss of intrathymic precursor activity.
Academic Article	Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay.
Academic Article	Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice.
Academic Article	The molecular bases of spontaneous immunological mutations in the mouse and their homologous human diseases.
Academic Article	Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand.
Academic Article	DNA-binding antibodies from viable motheaten mutant mice: implications for B cell tolerance.
Academic Article	Presence of intestinal intraepithelial lymphocytes in mice with severe combined immunodeficiency disease.
Academic Article	Aberrant regulation of bone trace elements in motheaten and osteopetrosis mutant mice.
Academic Article	Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.
Academic Article	Brugian infections in the peritoneal cavities of laboratory mice: kinetics of infection and cellular responses.
Academic Article	Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice.
Academic Article	The pathophysiological significance of nondesmoglein targets of pemphigus autoimmunity. Development of antibodies against keratinocyte cholinergic receptors in patients with pemphigus vulgaris and pemphigus foliaceus.
Academic Article	Establishment and characterization of pro-B cell lines from motheaten mutant mouse defective in SHP-1 protein tyrosine phosphatase.
Academic Article	Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice.
Academic Article	Isolation and characterization of a monoclonal anti-quadruplex DNA antibody from autoimmune "viable motheaten" mice.
Academic Article	IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection.
Academic Article	T cell receptor expression is not required for the localization and differentiation of intraepithelial lymphocytes.
Academic Article	Bombesin/gastrin-releasing peptide receptor: a potential target for antibody-mediated therapy of small cell lung cancer.
Academic Article	Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Academic Article	Roles of a macrophage receptor with collagenous structure (MARCO) in host defense and heterogeneity of splenic marginal zone macrophages.
Academic Article	Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleen.
Academic Article	A new murine model of humoral immuno-deficiency specifically affects class switching to T-independent antigens.
Academic Article	Immunity in experimental murine filariasis: roles of T and B cells revisited.
Academic Article	Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Academic Article	The soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro maintenance and proliferation of human CD34(+)CD38(-/low) cells capable of repopulating severe combined immunodeficiency mice.
Academic Article	Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.
Academic Article	Immunological mutants of the mouse.
Academic Article	T cells facilitate Brugia malayi development in TCRalpha(null) mice.
Academic Article	Apoptosis and the thymic microenvironment in murine lupus.
Academic Article	Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Academic Article	Phorbol ester responsiveness of murine Ly-1-lineage B cells from normal and viable motheaten mutant mice.
Academic Article	NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Academic Article	B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites.
Academic Article	TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1.
Academic Article	Humanized mice: are we there yet?
Academic Article	Expression of terminal differentiation proteins defines stages of mouse mammary gland development.
Academic Article	Isolation of permanent clonal bone marrow stromal cell lines derived from "viable moth-eaten" and "severe combined immunodeficiency" mutant mice.
Academic Article	Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytes.
Academic Article	Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi.
Academic Article	Lanceolate hair-J (lahJ): a mouse model for human hair disorders.
Academic Article	Transplantation analysis of B cell destruction in (NOD x CBA)F1 mouse bone marrow chimeras.
Academic Article	Effects of macrophage-colony-stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor.
Academic Article	Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions.
Academic Article	Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome: a reappraisal of paraneoplastic pemphigus.
Academic Article	Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.
Academic Article	Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
Academic Article	Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
Academic Article	The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice.
Academic Article	Creation of "humanized" mice to study human immunity.
Academic Article	Mouse neutrophils lacking lamin B-receptor expression exhibit aberrant development and lack critical functional responses.
Academic Article	In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties.
Academic Article	Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Academic Article	The mouse mutant "motheaten". I. Development of lymphocyte populations.
Academic Article	The mouse mutant "motheaten." II. Functional studies of the immune system.
Academic Article	Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Academic Article	Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice.
Academic Article	Fas deficiency delays the resolution of airway hyperresponsiveness after allergen sensitization and challenge.
Academic Article	Lymphohemopoiesis in culture is prevented by interaction with adherent bone marrow cells from mutant viable motheaten mice.
Academic Article	Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
Academic Article	Synthesis of abnormal immunoglobulins by hybridomas from autoimmune "viable motheaten" mutant mice.
Academic Article	Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
Academic Article	Dysferlin deficiency and the development of cardiomyopathy in a mouse model of limb-girdle muscular dystrophy 2B.
Academic Article	Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasite.
Academic Article	Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
Academic Article	Humanized mouse models to study human diseases.
Academic Article	Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice.
Academic Article	Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.
Academic Article	Defective in vitro migratory capacity of bone marrow cells from viable motheaten mice in response to normal thymus culture supernatants.
Academic Article	Granuloma formation around filarial larvae triggered by host responses to an excretory/secretory antigen.
Academic Article	Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis.
Academic Article	Pneumocystis carinii pneumonia in scid/scid mice.
Academic Article	Human allograft rejection in humanized mice: a historical perspective.
Academic Article	Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
Academic Article	Characterization of Mott cell hybridomas from autoimmune "viable motheaten" mutant mice.
Academic Article	Antibody repertoires in humanized NOD-scid-IL2R?(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse.
Academic Article	Humanized mice for immune system investigation: progress, promise and challenges.
Academic Article	Increased frequency of pre-pro B cells in the bone marrow of New Zealand Black (NZB) mice: implications for a developmental block in B cell differentiation.
Academic Article	Primed peritoneal B lymphocytes are sufficient to transfer protection against Brugia pahangi infection in mice.
Academic Article	Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model.
Academic Article	T cells are required for host protection against Brugia malayi but need not produce or respond to interleukin-4.
Academic Article	Mouse models of genetic diseases.
Academic Article	Pleiotropic effects of deleterious alleles at the "motheaten" locus.
Academic Article	Development of plasmacytoid cells with Russell bodies in autoimmune "viable motheaten" mice.
Academic Article	Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. II. Description of a microenvironmental defect for the generation of terminal deoxynucleotidyltransferase-positive bone marrow cells in vitro.
Academic Article	Pleiotropic mutations causing abnormalities in the murine immune system and the skin.
Academic Article	Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Academic Article	Hematopoiesis and models of immunodeficiency.
Academic Article	Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.
Academic Article	NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.
Academic Article	Fate of listeria monocytogenes in normal rabbit serum.
Academic Article	Cytotoxicity of rabbit blood for Listeria monocytogenes.
Academic Article	Distinct osteoclast precursors in the bone marrow and extramedullary organs characterized by responsiveness to Toll-like receptor ligands and TNF-alpha.
Academic Article	The effect of immunosuppression on streptozotocin-induced diabetes in C57BL/KsJ mice.
Academic Article	Immunodeficiency and reticulum cell sarcoma in mice segregating for HRS/J and SJL/J genes.
Academic Article	Novel B-cell maturation factor from spontaneously autoimmune viable motheaten mice.
Academic Article	Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras.
Academic Article	High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
Academic Article	Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.
Academic Article	Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis.
Academic Article	Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice.
Academic Article	CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Academic Article	Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
Academic Article	Engraftment of human lymphocytes and thyroid tissue into scid and rag2-deficient mice: absent progression of lymphocytic infiltration.
Academic Article	Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors.
Academic Article	Preservation of functioning human thyroid "organoids" in the severe combined immunodeficient mouse. III. Thyrotropin independence of thyroid follicle formation.
Academic Article	Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice.
Academic Article	Granulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donors.
Academic Article	Cellular requirements for functional reconstitution of follicular dendritic cells in SCID mice.
Academic Article	Epidermal dendritic cell populations in the flaky skin mutant mouse.
Academic Article	Differentiation of dendritic cell populations in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation.
Academic Article	Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor.
Academic Article	Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
Academic Article	Immunodeficient mice as hosts for hemoparasitic infections.
Academic Article	Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
Academic Article	Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Academic Article	Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.
Academic Article	The immunodeficient scid mouse as a model for human lymphatic filariasis.
Academic Article	TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
Academic Article	The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness.
Academic Article	The SCID-hu mouse and thyroid autoimmunity: characterization of human thyroid autoantibody secretion.
Academic Article	Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes.
Academic Article	Humanized mice in translational biomedical research.
Academic Article	Effect of genetically determined immunodeficiency on epidermal dendritic cell populations in C57BL/6J mice.
Academic Article	Acute but not chronic macrophage recruitment in filarial infections in mice is dependent on C-C chemokine ligand 2.
Academic Article	Determinants of memory in experimental filarial infections in mice.
Academic Article	A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Academic Article	CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL.
Academic Article	Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice.
Academic Article	Humanized SCID mouse models for biomedical research.
Academic Article	A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Academic Article	Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains.
Academic Article	T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.
Academic Article	Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.
Academic Article	Humanized mice for the study of type 1 diabetes and beta cell function.
Academic Article	Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.
Academic Article	TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
Academic Article	Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells.
Academic Article	Identification of Pneumocystis carinii in immunodeficient mice.
Academic Article	Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML.
Academic Article	Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.
Academic Article	Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.
Academic Article	Outbreaks of Pneumocystis carinii pneumonia in colonies of immunodeficient mice.
Academic Article	Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
Academic Article	Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2r?(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease.
Academic Article	Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev).
Academic Article	Humanized mice as a preclinical tool for infectious disease and biomedical research.
Academic Article	Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
Academic Article	Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice.
Academic Article	The mouse mutation severe combined immune deficiency (scid) is on chromosome 16.
Academic Article	Humanized mice for the study of infectious diseases.
Academic Article	Non-germ-line elements (NGE) are present in the T cell receptor beta-chain genes isolated from the mutant mouse, motheaten (me/me).
Academic Article	NOD marrow stem cells adoptively transfer diabetes to resistant (NOD x NON)F1 mice.
Academic Article	The immunological mouse mutants nude (nu) and rhino (hrrh) generate cytotoxic effector cells following adoptive immunotherapy but fail to reject a transplanted tumor.
Academic Article	Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.
Academic Article	Genetically determined murine models of immunodeficiency.
Academic Article	Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice.
Academic Article	Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice.
Academic Article	Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins.
Academic Article	A serum-derived molecule from autoimmune viable motheaten mice potentiates the action of a B cell maturation factor.
Academic Article	Mutations in mice that influence natural killer (NK) cell activity.
Academic Article	In the absence of a CD40 signal, B cells are tolerogenic.
Academic Article	Thymic epithelial cell abnormalities in (NZB x H-2u)F1 mice.
Academic Article	Maintenance of CD5+ B cells at an early developmental stage by interleukin-5: evidence from immunoglobulin gene usage in interleukin-5 transgenic mice.
Academic Article	Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice.
Academic Article	Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols.
Academic Article	B lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Academic Article	Programmed differentiation of murine thymocytes during fetal thymus organ culture.
Academic Article	Antiviral activity of NK 1.1+ natural killer cells in C57BL/6 scid mice infected with murine cytomegalovirus.
Academic Article	Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology.
Academic Article	Localization of prothymocytes from wild-type and viable motheaten mice following intravenous injection into irradiated adoptive recipients.
Academic Article	Effects of macrophage colony-stimulating factor (M-CSF) on the development, differentiation, and maturation of marginal metallophilic macrophages and marginal zone macrophages in the spleen of osteopetrosis (op) mutant mice lacking functional M-CSF activity.
Academic Article	The role of macrophage colony-stimulating factor in hepatic glucan-induced granuloma formation in the osteopetrosis mutant mouse defective in the production of macrophage colony-stimulating factor.
Academic Article	Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice.
Academic Article	Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. Influence of B and T cells.
Concept	Immunotherapy
Concept	Enzyme-Linked Immunosorbent Assay
Concept	Cytotoxicity Tests, Immunologic
Concept	Immunity, Cellular
Concept	Immunoassay
Concept	Graft Enhancement, Immunologic
Concept	Immunoglobulin Variable Region
Concept	Immune System Diseases
Concept	Immunity
Concept	Immunoglobulin D
Concept	Chromatin Immunoprecipitation
Concept	Immunochemistry
Concept	Syndrome
Concept	Transplantation Immunology
Concept	Models, Immunological
Concept	Immunophenotyping
Concept	Immunosuppressive Agents
Concept	Genes, Immunoglobulin
Concept	Immunocompromised Host
Concept	Immunoglobulins
Concept	Immunoprecipitation
Concept	Dose-Response Relationship, Immunologic
Concept	Acquired Immunodeficiency Syndrome
Concept	Immunoenzyme Techniques
Concept	tat Gene Products, Human Immunodeficiency Virus
Concept	Immunity, Innate
Concept	Adjuvants, Immunologic
Concept	Immunoglobulin M
Concept	Immunity, Humoral
Concept	Immunoglobulin G
Concept	Immunologic Deficiency Syndromes
Concept	Severe Combined Immunodeficiency
Concept	Cytotoxicity, Immunologic
Concept	Immunization, Passive
Concept	Immunoglobulin E
Concept	Paraneoplastic Syndromes
Concept	Immunoglobulin Fragments
Concept	Immunocompetence
Concept	Immunotherapy, Adoptive
Concept	Immunoglobulin Heavy Chains
Concept	Immunoglobulin Isotypes
Concept	Immunoconjugates
Concept	Adaptive Immunity
Concept	Immune System
Concept	Immunoglobulin Class Switching
Concept	Receptors, Immunologic
Concept	Microscopy, Immunoelectron
Concept	Immunization
Concept	Systemic Inflammatory Response Syndrome
Concept	Immunoglobulin mu-Chains
Concept	Immunity, Maternally-Acquired
Concept	Immunoglobulin Subunits
Concept	Immunohistochemistry
Concept	Immune Tolerance
Concept	Immunoblotting
Concept	Immunologic Memory
Academic Article	Overcoming current limitations in humanized mouse research.
Academic Article	Novel neuroprotective GSK-3? inhibitor restricts Tat-mediated HIV-1 replication.
Academic Article	Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice.
Academic Article	Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2r?(null) mice treated with alogliptin.
Academic Article	An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
Academic Article	Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.
Academic Article	Human cancer growth and therapy in immunodeficient mouse models.
Academic Article	Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development.
Academic Article	Generation of improved humanized mouse models for human infectious diseases.
Academic Article	Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice.
Academic Article	Generation of ? cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.
Academic Article	Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia.
Academic Article	Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.
Academic Article	The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.
Academic Article	Humanized Mouse Models for Transplant Immunology.
Academic Article	Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.
Academic Article	Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.
Academic Article	Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.
Academic Article	Genetically modified human CD4(+) T cells can be evaluated in?vivo without lethal graft-versus-host disease.
Academic Article	Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.
Academic Article	Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice.
Academic Article	Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis.
Academic Article	Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury.
Academic Article	Humanized Mouse Models of Clinical Disease.
Academic Article	Improved B cell development in humanized NOD-scid IL2R?null mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3.
Academic Article	Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice.
Academic Article	Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing.
Academic Article	A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo.
Academic Article	Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice.
Academic Article	Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy.
Academic Article	Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery.
Academic Article	Mechanisms of genetically determined immune dysfunction.
Academic Article	A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation.
Academic Article	Human immune system development and survival of non-obese diabetic (NOD)-scid IL2r?(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.
Academic Article	Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics.
Academic Article	Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.
Academic Article	Humanized mouse models of immunological diseases and precision medicine.
Academic Article	Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.
Academic Article	Humanized immune system mouse models: progress, challenges and opportunities.
Academic Article	Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.
Academic Article	AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.
Academic Article	Tacrolimus- and sirolimus-induced human ? cell dysfunction is reversible and preventable.
Academic Article	TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice.
Academic Article	Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils.
Academic Article	Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice.
Academic Article	A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome.
Academic Article	Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis.
Academic Article	Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
Academic Article	Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia.
Academic Article	Preclinical evaluation of cancer immune therapy using patient-derived tumor antigen-specific T cells in a novel xenograft platform.
Academic Article	Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments.
Academic Article	Circulating CD34+?cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice.
Academic Article	Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15.
Academic Article	Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment.
Academic Article	Humanized mouse models for immuno-oncology research.
Academic Article	Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis.
Academic Article	NOD-scid IL2r?null mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.

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