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Search Results to Leonard Donald Shultz PhD

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One or more keywords matched the following items that are connected to Shultz, Leonard

Item TypeName
Academic Article Lack of peripherally induced tolerance to established skin allografts in immunologically reconstituted scid mice.
Academic Article Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.
Academic Article Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells.
Academic Article Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients.
Academic Article Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice.
Academic Article LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors.
Academic Article Role of tumor necrosis factor-alpha in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice.
Academic Article Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras.
Academic Article Follicular dendritic cell (FDC) precursors in primary lymphoid tissues.
Academic Article SCID mouse models of human stem cell engraftment.
Academic Article Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.
Academic Article Tumorigenicity of green turtle fibropapilloma-derived fibroblast lines in immunodeficient mice.
Academic Article NOD mice have a generalized defect in their response to transplantation tolerance induction.
Academic Article Evaluation of monoclonal antibody-mediated anti-acute myeloid leukemia immunotherapy in a SCID/hu model.
Academic Article The plant lectin FRIL supports prolonged in vitro maintenance of quiescent human cord blood CD34(+)CD38(-/low)/SCID repopulating stem cells.
Academic Article Thymic involution in viable motheaten (me(v)) mice is associated with a loss of intrathymic precursor activity.
Academic Article Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay.
Academic Article Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice.
Academic Article Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand.
Academic Article Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice.
Academic Article Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.
Academic Article Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody.
Academic Article Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice.
Academic Article Continuous infusion of endostatin inhibits differentiation, mobilization, and clonogenic potential of endothelial cell progenitors.
Academic Article Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5.
Academic Article Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
Academic Article Bombesin/gastrin-releasing peptide receptor: a potential target for antibody-mediated therapy of small cell lung cancer.
Academic Article Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Academic Article Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleen.
Academic Article Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Academic Article The soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro maintenance and proliferation of human CD34(+)CD38(-/low) cells capable of repopulating severe combined immunodeficiency mice.
Academic Article Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.
Academic Article Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.
Academic Article An assay for human hematopoietic stem cells based on transplantation into nonobese diabetic recombination activating gene-null perforin-null mice.
Academic Article Human cord blood--derived cells generate insulin-producing cells in vivo.
Academic Article NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Academic Article Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion.
Academic Article Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytes.
Academic Article Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice.
Academic Article beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function.
Academic Article Transplantation analysis of B cell destruction in (NOD x CBA)F1 mouse bone marrow chimeras.
Academic Article Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.
Academic Article Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells.
Academic Article Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
Academic Article Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
Academic Article Effect of aging on epidermal dendritic cell populations in C57BL/6J mice.
Academic Article The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice.
Academic Article Creation of "humanized" mice to study human immunity.
Academic Article In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties.
Academic Article Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Academic Article Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Academic Article Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice.
Academic Article Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
Academic Article In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase.
Academic Article Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
Academic Article Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.
Academic Article Defective in vitro migratory capacity of bone marrow cells from viable motheaten mice in response to normal thymus culture supernatants.
Academic Article Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF.
Academic Article Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.
Academic Article Human allograft rejection in humanized mice: a historical perspective.
Academic Article Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
Academic Article Antibody repertoires in humanized NOD-scid-IL2R?(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse.
Academic Article In vitro and in vivo hematopoietic potential of human stem cells residing in muscle tissue.
Academic Article Establishment and characterization of a new osteogenic cell line (MOS-J) from a spontaneous C57BL/6J mouse osteosarcoma.
Academic Article Humanized mice for immune system investigation: progress, promise and challenges.
Academic Article A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.
Academic Article The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.
Academic Article Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Academic Article Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells.
Academic Article Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.
Academic Article NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.
Academic Article The effect of immunosuppression on streptozotocin-induced diabetes in C57BL/KsJ mice.
Academic Article Hematopoietic stem cell function in motheaten mice.
Academic Article Transgenic mice expressing either bovine growth hormone (bGH) or human GH releasing hormone (hGRH) have increased splenic progenitor cell colony formation and DNA synthesis in vitro and in vivo.
Academic Article Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras.
Academic Article High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
Academic Article Cellular origin of follicular dendritic cells.
Academic Article Abnormal nuclear morphology of leukocytes in the mouse mutant ichthyosis.
Academic Article Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
Academic Article Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice.
Academic Article Granulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donors.
Academic Article Preservation of functioning human thyroid organoids in the scid mouse: 1. System characterization.
Academic Article Preservation of functioning human thyroid organoids in the scid mouse: II. Biased use of intrathyroidal T cell receptor V genes.
Academic Article Cellular requirements for functional reconstitution of follicular dendritic cells in SCID mice.
Academic Article Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
Academic Article Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
Academic Article Human cord blood- and bone marrow-derived CD34+ cells regenerate gastrointestinal epithelial cells.
Academic Article Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Academic Article Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Academic Article Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.
Academic Article Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/beta2-microglobulin(null) mice.
Academic Article Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signature.
Academic Article TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
Academic Article Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration.
Academic Article The SCID-hu mouse and thyroid autoimmunity: characterization of human thyroid autoantibody secretion.
Academic Article Treatment and transfer of emphysema by a new bone marrow transplantation method from normal mice to Tsk mice and vice versa.
Academic Article Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.
Academic Article In vivo distribution of human adipose-derived mesenchymal stem cells in novel xenotransplantation models.
Academic Article Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.
Academic Article A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Academic Article CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL.
Academic Article Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice.
Academic Article A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Academic Article Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.
Academic Article Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains.
Academic Article Humanized mice for the study of type 1 diabetes and beta cell function.
Academic Article Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.
Academic Article TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
Academic Article Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
Academic Article Human nasal polyp microenvironments maintained in a viable and functional state as xenografts in NOD-scid IL2rgamma(null) mice.
Academic Article NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.
Academic Article Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells.
Academic Article Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.
Academic Article Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.
Academic Article Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.
Academic Article Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
Academic Article Humanized mice as a preclinical tool for infectious disease and biomedical research.
Academic Article Humanized mice for the study of type 1 and type 2 diabetes.
Academic Article Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2R?(null) mice.
Academic Article Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
Academic Article Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice.
Academic Article NOD marrow stem cells adoptively transfer diabetes to resistant (NOD x NON)F1 mice.
Academic Article The immunological mouse mutants nude (nu) and rhino (hrrh) generate cytotoxic effector cells following adoptive immunotherapy but fail to reject a transplanted tumor.
Academic Article Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.
Academic Article Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice.
Academic Article Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols.
Academic Article Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. Influence of B and T cells.
Concept Hematopoietic Stem Cell Transplantation
Concept Bone Marrow Transplantation
Concept Transplantation Immunology
Concept Mesenchymal Stem Cell Transplantation
Concept Transplantation Tolerance
Concept Transplantation, Heterologous
Concept Transplantation Conditioning
Concept Fetal Tissue Transplantation
Concept Transplantation Chimera
Concept Tissue Transplantation
Concept Transplantation, Homologous
Concept Skin Transplantation
Concept Cord Blood Stem Cell Transplantation
Concept Liver Transplantation
Concept Peripheral Blood Stem Cell Transplantation
Concept Organ Transplantation
Concept Stem Cell Transplantation
Concept Neoplasm Transplantation
Concept Cell Transplantation
Concept Islets of Langerhans Transplantation
Academic Article Subcapsular transplantation of tissue in the kidney.
Academic Article Human cancer growth and therapy in immunodeficient mouse models.
Academic Article Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development.
Academic Article Viral infection of engrafted human islets leads to diabetes.
Academic Article Generation of improved humanized mouse models for human infectious diseases.
Academic Article MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.
Academic Article Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.
Academic Article Humanized Mouse Models for Transplant Immunology.
Academic Article Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.
Academic Article Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.
Academic Article Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease.
Academic Article Human immune system development and survival of non-obese diabetic (NOD)-scid IL2r?(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.
Academic Article Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics.
Academic Article Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency.
Academic Article Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain.

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