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One or more keywords matched the following properties of Henninger, Nils
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Biography

Dr. Henninger received his M.D. degree from the University of Mainz, Germany. Following residency training in Neurology at the University of Heidelberg, Germany and University of Massachusetts Medical School, Worcester, MA he completed a fellowship in Cerebrovascular Diseases at the Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA before joining the University of Massachusetts Medical School in 2012.

Research Program

As a cerebrovascular disease-trained neurologist I mostly see stroke patients in my clinic but I am broadly interested in emergency neurology. The overarching goal of my research is to define mechanisms driving white matter damage and its contribution to functional outcome after brain injury.

My main basic science research is aimed at understanding the molecular mechanisms underlying axonal degeneration in the brain after acute brain injury. My research has provided first evidence that by blocking a key gene driving Wallerian degeneration, Sarm1, it is possible to prevent axonal degeneration and preserve neurological function after brain trauma. These fundamental observations indicate that traumatic axonal degeneration is governed by a Wallerian degeneration-like mechanism and represent the first evidence that it is possible to prevent axonal degeneration after mammalian brain trauma in vivo. This is a major step forward in the field of traumatic brain injury, which represents a leading cause of adult disability and death in the US and for which there is no specific therapy available.

Positions

--We accept residents and fellows year on a  case-by-case basis to work on mentored clinical research projects.

--There are presently no vacancies in our lab.

Summary Dr. Henninger is a vascular neurologist with research interest in the neurobiology of axonal injury associated with traumatic brain injury and its contribution to functional outcome.
One or more keywords matched the following items that are connected to Henninger, Nils
Item TypeName
Academic Article Combination therapy of moderate hypothermia and thrombolysis in experimental thromboembolic stroke--an MRI study.
Academic Article Statin use and microbleeds in patients with spontaneous intracerebral hemorrhage.
Academic Article Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat.
Academic Article Leukoaraiosis predicts poor 90-day outcome after acute large cerebral artery occlusion.
Concept Trauma Severity Indices
Concept Injury Severity Score
Concept Severity of Illness Index
Academic Article Severe leukoaraiosis portends a poor outcome after traumatic brain injury.
Academic Article Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke.
Academic Article Low Serum Vitamin D Is Independently Associated with Larger Lesion Volumes after Ischemic Stroke.
Academic Article Response to Letter Regarding Article, "Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke".
Academic Article Clinical impact of leukoaraiosis burden and chronological age on neurological deficit recovery and 90-day outcome after minor ischemic stroke.
Academic Article Impact of Leukoaraiosis Burden on Hemispheric Lateralization of the National Institutes of Health Stroke Scale Deficit in Acute Ischemic Stroke.
Academic Article Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1.
Academic Article White Matter Hyperintensity-Adjusted Critical Infarct Thresholds to Predict a Favorable 90-Day Outcome.
Academic Article "Don't lose hope early": Hemorrhagic diffuse axonal injury on head computed tomography is not associated with poor outcome in moderate to severe traumatic brain injury patients.
Academic Article Cortical Spreading Depression Denotes Concussion Injury.
Academic Article Pre-existing White Matter Hyperintensity Lesion Burden and Diagnostic Certainty of Transient Ischemic Attack.
Academic Article Leukoaraiosis Predicts Short-term Cognitive But not Motor Recovery in Ischemic Stroke Patients During Rehabilitation.
Academic Article Impact of Leukoaraiosis Severity on the Association of Time to Successful Reperfusion with 90-Day Functional Outcome After Large Vessel Occlusion Stroke.
Academic Article Relationship of white matter lesion severity with early and late outcomes after mechanical thrombectomy for large vessel stroke.
Academic Article SARS-CoV-2 and Stroke in a New York Healthcare System.
Academic Article Mean platelet volume and its genetic variants relate to stroke severity and 1-year mortality.
Academic Article Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.
Academic Article Differential association of baseline body weight and body-weight loss with neurological deficits, histology, and death after repetitive closed head traumatic brain injury.
Concept Chronic Traumatic Encephalopathy
Concept Brain Injuries, Traumatic
Search Criteria
  • Moderate
  • Severe
  • Traumatic Brain Injury