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Nuclear Medicine Physics Imaging Research Interests

  • Correction for causes of image degradation in nuclear medicine such as attenuation, distance-dependent spatial-resolution, and scatter
  • Detection, estimation, and correction of all forms of patient motion during imaging
  • Tomographic image reconstruction for SPECT and PET.
  • Combination of CT with SPECT and PET
  • Design of the next generation of SPECT Imaging Systems
  • Assessment of image quality by task performance studies using human and numerical observers.
  • Quantification of activity and assessment of physiological function.
  • Image segmentation and computer vision applications in nuclear medicine.
  • Reduction in radiation dose to patients and personnel
  • Applications of Deep Learning in Nuclear Medicine

One example of the research accomplishments of the laboratory is our work on the detection and compensation of patient motion during the up to 16 minute period which the patient is required to remain motionless for nuclear medicine studies. We have taken the approach of combining estimates of patient motion as determined from the nuclear medicine images themselves with information from our visual-tracking system (VTS) which tracks the motion of retro-reflective markers on stretchy bands wrapped about the patient to provide a combined correction of respiratory and bodily motion. Once motion is determined it is corrected by inclusion in iterative reconstruction as illustrated in the following figure. These investigations are funded by NIH grant R01-HL122484.

Clinical SPECT
Clinical SPECT images showing benefits of respiratory motion correction (RM) as noted in top row versus second row which is without RM correction.

Another example of our current interests is the development of a multi-pinhole collimator (MPH) for use on one gamma-camera head of a general purpose SPECT system in combination with a fan-beam collimator on the second camera head for high resolution / sensitivity imaging of the striatal region of the brain in I-123 DaTscan imaging for Parkinson’s Disease. A rendering of the collimator is shown below followed by reconstructed simulated images of the strata for MPH, Fan, and Combined imaging. These investigations are funded by NIH grant R01-EB022092.

MPH collimator
Rendering of the MPH collimator showing the aperture plate with 9 pinholes.
A. Example XCAT transverse slice multi-pinhole (MPH) collimator noise-free reconstructions through substantia nigra (left) and the caudate and putamen (right) for 15, 30, and 60 angles for VOI over striata. B. Same for low-energy ultra-high-resolution (LEUHR) fan-beam only collimator reconstruction. C. Same for combined reconstruction using MPH and LEUHR fan-beam collimators. D. Matching slices through original XCAT DaTscan source distribution for substantia nigra (top), and caudate and putamen (bottom) with 8:1 striatal to rest of brain  concentration ratio, and no activity in the ventricles. Note that separation of caudate and putamen can be seen in combined reconstruction.

The third example of our current investigations is the development of a multi-detector-module multi-pinhole (MPH) SPECT brain-imaging system ideally suited for quantitative dynamic and high-spatial-resolution static SPECT imaging. Dynamic imaging will be enabled by obtaining sufficient angular sampling without the need for rotation. The system will automatically adapt its imaging characteristics (aperture size and number of pinholes open for imaging) in response to the imaging tasks and individual patients. It will thereby optimize lesion detection and quantification, as well as provide optimal data for pharmacokinetic analysis within structures throughout the brain. The prototype design for this system is illustrated in the following computer aided design (CAD) drawings.  These investigations are funded by NIH grant R01-EB022521.

Frontal view SolidWorks CADRear view SolidWorks CAD
Shown left is a frontal view and right is a view from behind of SolidWorks CAD renderings of the proposed prototype configuration of the 23 detectors of the system dedicated to brain SPECT imaging. Shown are detector modules with MPH aperture plates towards the brain and circular scintillation detector crystals opposed to them.

Current Teaching

Physics of Radiology for Residents Nuclear Medical Physics for Cardiologists A year long course starting in August each year consisting of one-hour lectures plus quizzes on Wednesday mornings each week.

Physics Review for Radiology Residents Taking the ABR Exam Nuclear Medical Physics for Cardiologists: Lectures, demonstrations, and practice question review for physics portion of ABR exam from January to June.

List of Graduate Students and Post-Doctoral Fellows List of Graduate Students

Honors and Awards

  1. Graduated Magna Cum Laude from the State University of New York at Oswego in 1969
  2. Anne-Dorte Achtert, 4th year medical student from Humboldt University, Berlin. Advisor for 1 year research fellowship under Biomedical Sciences Exchange Program, 1996-1997. Manuscript based on directed research (JNC 5:144-152, 1997) won the Best Scientific Paper Award from the Journal of Nuclear Cardiology for 1998.
  3. Daniel deVries, thesis advisor for Doctor's degree (1996) in Biomedical Engineering from Worcester Polytechnic Institute. Paper based on thesis work (JNM 40:1011-1023, 1999) received The Journal of Nuclear Medicine's First Place Award for Outstanding Basic Science Manuscript for 1999.
  4. Ed Hoffman Memorial Award for Outstanding Scientific Contributions to the Field of Computers and Instrumentation in Nuclear Medicine. From Society of Nuclear Medicine Computer and Instrumentation Council. June 5, 2006.
  5. Teacher of the Year Award for excellence in teaching presented by the residents of the Department of Radiology, UMMS, June 11, 2008.
  6. IEEE Nuclear and Plasma Sciences Society 2015 Edward J Hoffman Medical Imaging Scientist Award for contributions to clinical nuclear medicine imaging, especially compensation for realistic physical effects and motion in image reconstruction, emission and transmission imaging geometries, and task-based evaluation methods. Nov 4, 2015.
  7. Charter Member of the Biomedical Imaging Technology-A Study Section, Center for Scientific Review, NIH, from July 1, 2016 to June 30, 2020.
  8. Fellow Society of Nuclear Medicine and Molecular Imaging. June 14, 2020

Current Grant Support

  1. NIH, No R01-EB022092, Combined Multi-Pinhole and Fan-Beam Brain SPECT. M. A. King, PI, 5/18/2016-2/29/2021 (no cost extension).
  2. NIH, No. R01 EB022521, AdaptiSPECT-C: A Next-Generation, Adaptive Brain-Imaging SPECT System for Drug Discovery and Clinical Imaging, M. A. King, contact PI, L. Furenlid, MPI, G. Zubal, MPI, 9/1/2016-8/30/2021.
  3. NIH, No. R21 EB027250, Wave-Cam: A novel micro-radar imaging array for non-rigid motion estimation in hybrid medical imaging, C. Lindsay, PI, 9/21/2019 – 6/30/2022, Role: Co-investigator.
  4. NIH, No. R01 EB029315, Improving Pediatric SPECT Imaging: Enhanced Lesion Detection with Dose Reduction through Advanced Reconstruction and Motion Correction, M. A. King, contact PI, F. Fahey, MPI, Y. Yang, MPI, 6/01/2020 – 0/29/2024.
  5. NIH, No. R01 HL154687, Optimization of diagnostic accuracy, radiation dose, and patient throughput for cardiac SPECT via advanced and clinically practical cardiac-respiratory motion correction and deep learning, W. Wernick, contact PI, M. A. King, MPI, 06/01/20-05/31/24.
  6. NIH, No. R15 HL150708, Attenuation correction strategies for myocardial perfusion imaging using dual-gated, M. Jin, PI 8/05/2020 – 07/31/2023, $300,000, Role: Co-investigator.
One or more keywords matched the following items that are connected to King, Michael
Item TypeName
Academic Article An analytical approach for compensation of non-uniform attenuation in cardiac SPECT imaging.
Academic Article Transmission imaging of large attenuators using a slant hole collimator on a three-headed SPECT system.
Academic Article A Monte Carlo investigation of artifacts caused by liver uptake in single-photon emission computed tomography perfusion imaging with technetium 99m-labeled agents.
Academic Article Attenuation compensation for cardiac single-photon emission computed tomographic imaging: Part 2. Attenuation compensation algorithms.
Academic Article Evaluation of right and left ventricular volume and ejection fraction using a mathematical cardiac torso phantom.
Academic Article A method of simultaneous dual-radionuclide cardiac imaging with technetium 99m and thallium 201. I: Analysis of interradionuclide crossover and validation in phantoms.
Academic Article Attenuation compensation for cardiac single-photon emission computed tomographic imaging: Part 1. Impact of attenuation and methods of estimating attenuation maps.
Academic Article Influence of OSEM, elliptical orbits and background activity on SPECT 3D resolution recovery.
Academic Article Reducing the influence of the partial volume effect on SPECT activity quantitation with 3D modelling of spatial resolution in iterative reconstruction.
Academic Article Comparison of frequency-distance relationship and Gaussian-diffusion-based methods of compensation for distance-dependent spatial resolution in SPECT imaging.
Academic Article Attenuation compensation in 99mTc SPECT brain imaging: a comparison of the use of attenuation maps derived from transmission versus emission data in normal scans.
Academic Article Bone SPECT of the spine: a comparison of attenuation correction techniques.
Academic Article The effect of intrinsic attenuation correction methods on the stationarity of the 3-D modulation transfer function of SPECT.
Academic Article Channelized hotelling and human observer correlation for lesion detection in hepatic SPECT imaging.
Academic Article A dual-photopeak window method for scatter correction.
Academic Article Comparing filtered backprojection and ordered-subsets expectation maximization for small-lesion detection and localization in 67Ga SPECT.
Academic Article Improved image quality and computation reduction in 4-D reconstruction of cardiac-gated SPECT images.
Academic Article LROC analysis of detector-response compensation in SPECT.
Academic Article Comparative evaluation of image segmentation methods for volume quantitation in SPECT.
Academic Article Improvement of image resolution and quantitative accuracy in clinical Single Photon Emission Computed Tomography.
Academic Article Estimation of attenuation maps from scatter and photopeak window single photon-emission computed tomographic images of technetium 99m-labeled sestamibi.
Academic Article An investigation of the estimation of ejection fractions and cardiac volumes by a quantitative gated SPECT software package in simulated gated SPECT images.
Academic Article An iterative transmission algorithm incorporating cross-talk correction for SPECT.
Academic Article Quantitative myocardial perfusion SPECT.
Academic Article Introduction to the physics of molecular imaging with radioactive tracers in small animals.
Academic Article Assessment of scatter compensation strategies for (67)Ga SPECT using numerical observers and human LROC studies.
Academic Article Effect of filtering on the detection and localization of small Ga-67 lesions in thoracic single photon emission computed tomography images.
Academic Article Effects of scatter substraction on detection and quantitation in hepatic SPECT.
Academic Article SPECT volume quantitation: influence of spatial resolution, source size and shape, and voxel size.
Academic Article A mathematical model of motion of the heart for use in generating source and attenuation maps for simulating emission imaging.
Academic Article Myocardial perfusion SPECT reconstruction: receiver operating characteristic comparison of CAD detection accuracy of filtered backprojection reconstruction with all of the clinical imaging information available to readers and solely stress slices iteratively reconstructed with combined compensation.
Academic Article Counting moles automatically from back images.
Academic Article Comparing cardiac ejection fraction estimation algorithms without a gold standard.
Academic Article Fully 4D motion-compensated reconstruction of cardiac SPECT images.
Academic Article An interior point iterative maximum-likelihood reconstruction algorithm incorporating upper and lower bounds with application to SPECT transmission imaging.
Academic Article Noniterative compensation for the distance-dependent detector response and photon attenuation in SPECT imaging.
Academic Article Relative importance of the error sources in Wiener restoration of scintigrams.
Academic Article Diminishing the impact of the partial volume effect in cardiac SPECT perfusion imaging.
Academic Article Impact on reader performance for lesion-detection/ localization tasks of anatomical priors in SPECT reconstruction.
Academic Article A flexible multicamera visual-tracking system for detecting and correcting motion-induced artifacts in cardiac SPECT slices.
Academic Article A quantitative evaluation study of four-dimensional gated cardiac SPECT reconstruction.
Academic Article Detectability of perfusion defect in five-dimensional gated-dynamic cardiac SPECT images.
Academic Article Estimation and correction of cardiac respiratory motion in SPECT in the presence of limited-angle effects due to irregular respiration.
Academic Article Quantitative iodine-123 IMP imaging of brain perfusion in schizophrenia.
Academic Article Investigation of causes of geometric distortion in 180 degrees and 360 degrees angular sampling in SPECT.
Academic Article Modifying constrained least-squares restoration for application to single photon emission computed tomography projection images.
Academic Article An image-dependent Metz filter for nuclear medicine images.
Academic Article Coping with perturbations to a layout somersault in tumbling.
Academic Article Effect of glucose and insulin infusion on the myocardial extraction of a radioiodinated methyl-substituted fatty acid.
Academic Article An overview of attenuation and scatter correction of planar and SPECT data for dosimetry studies.
Academic Article Human-observer receiver-operating-characteristic evaluation of attenuation, scatter, and resolution compensation strategies for (99m)Tc myocardial perfusion imaging.
Academic Article Acute osteomyelitis: advantage of white cell scans in early detection.
Academic Article Comparison of four scatter correction methods using Monte Carlo simulated source distributions.
Academic Article A comparison of human and model observers in multislice LROC studies.
Academic Article An investigation of the 3D modulation transfer function used in 3D post-reconstruction restoration filtering of SPECT imaging.
Academic Article 2D vs. 3D edge detection as a basis for volume quantitation in SPECT.
Academic Article Activity quantitation in SPECT: a study of prereconstruction Metz filtering and use of the scatter degradation factor.
Academic Article Simultaneous assessment of cardiac perfusion and function using 5-dimensional imaging with Tc-99m teboroxime.
Academic Article Use of three-dimensional Gaussian interpolation in the projector/backprojector pair of iterative reconstruction for compensation of known rigid-body motion in SPECT.
Academic Article Incorporation of system resolution compensation (RC) in the ordered-subset transmission (OSTR) algorithm for transmission imaging in SPECT.
Academic Article Reconstruction of dynamic gated cardiac SPECT.
Academic Article Segmentation of the body and lungs from Compton scatter and photopeak window data in SPECT: a Monte-Carlo investigation.
Academic Article Correction to "segmentation of the body and lungs from compton scatter and photopeak window data in.
Academic Article Characterization of the modulation transfer function of discrete filtered backprojection.
Academic Article An evaluation of iterative reconstruction strategies based on mediastinal lesion detection using hybrid Ga-67 SPECT images.
Academic Article Effects of motion, attenuation, and scatter corrections on gated cardiac SPECT reconstruction.
Academic Article Comparison study of temporal regularization methods for fully 5D reconstruction of cardiac gated dynamic SPECT.
Academic Article A quantitative study of motion estimation methods on 4D cardiac gated SPECT reconstruction.
Academic Article 4D reconstruction for low-dose cardiac gated SPECT.
Academic Article Stationary and nonstationary spatial domain Metz filtering.
Academic Article Constrained least-squares restoration of nuclear medicine images: selecting the coarseness function.
Academic Article A study of irradiated bone. Part II. changes in Tc-99m pyrophosphate bone imaging.
Academic Article Two-dimensional filtering of SPECT images using the Metz and Wiener filters.
Concept Septal Nuclei
Concept Disease Models, Animal
Concept Staphylococcus aureus
Concept Software
Concept Sensitivity and Specificity
Concept Information Storage and Retrieval
Concept Cell Survival
Concept Subtraction Technique
Concept Computer Simulation
Concept Spine
Concept Statistics as Topic
Concept Coronary Artery Disease
Concept Signal Processing, Computer-Assisted
Concept Reference Standards
Concept Stroke Volume
Concept Technetium Tc 99m Sestamibi
Concept Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography
Concept Retrospective Studies
Concept Models, Statistical
Concept Scattering, Radiation
Concept Schizophrenia
Concept Tomography, Emission-Computed, Single-Photon
Concept Systole
Concept Sex Factors
Concept Evaluation Studies as Topic
Concept Sternum
Concept Coronary Disease
Concept Alzheimer Disease
Concept Tomography, Spiral Computed
Concept Models, Structural
Concept Body Surface Potential Mapping
Concept Stochastic Processes
Concept Spleen
Concept Skin Neoplasms
Concept Muscle, Skeletal
Concept Heart Diseases
Concept Space Perception
Academic Article Digital restoration of indium-111 and iodine-123 SPECT images with optimized Metz filters.
Academic Article Deconvolution using orthogonal polynomials in nuclear medicine: a method for forming quantitative functional images from kinetic studies.
Academic Article An evaluation of data-driven motion estimation in comparison to the usage of external-surrogates in cardiac SPECT imaging.
Academic Article Comparison of methods of acquiring attenuation maps for cardiac SPECT in the presence of respiratory motion.
Academic Article Use of MRI to assess the prediction of heart motion with gross body motion in myocardial perfusion imaging by stereotracking of markers on the body surface.
Academic Article A method to synchronize signals from multiple patient monitoring devices through a single input channel for inclusion in list-mode acquisitions.
Academic Article Digital anthropomorphic phantoms of non-rigid human respiratory and voluntary body motion for investigating motion correction in emission imaging.
Academic Article Adaptation of the modified Bouc-Wen model to compensate for hysteresis in respiratory motion for the list-mode binning of cardiac SPECT and PET acquisitions: testing using MRI.
Academic Article Area weighted convolutional interpolation for data reprojection in single photon emission computed tomography.
Academic Article Comparison of the scanning linear estimator (SLE) and ROI methods for quantitative SPECT imaging.
Academic Article Limited-angle effect compensation for respiratory binned cardiac SPECT.
Academic Article Improved frame-based estimation of head motion in PET brain imaging.
Academic Article Body Deformation Correction for SPECT Imaging.
Academic Article Estimation of Cardiac Respiratory-Motion by Semi-Automatic Segmentation and Registration of Non-Contrast-Enhanced 4D-CT Cardiac Datasets.
Academic Article Theoretical and Numerical Study of MLEM and OSEM Reconstruction Algorithms for Motion Correction in Emission Tomography.
Academic Article Estimation of Rigid-Body and Respiratory Motion of the Heart From Marker-Tracking Data for SPECT Motion Correction.
Academic Article Evaluation of Multiclass Model Observers in PET LROC Studies.
Academic Article Estimation of 6-Degree-of-Freedom (6-DOF) Rigid-Body Patient Motion From Projection Data by the Principal-Axes Method in Iterative Reconstruction.
Academic Article MRI Investigation of the Linkage Between Respiratory Motion of the Heart and Markers on Patient's Abdomen and Chest: Implications for Respiratory Amplitude Binning List-Mode PET and SPECT Studies.
Academic Article Quantitative Study of Rigid-Body and Respiratory Motion of Patients Undergoing Stress and Rest Cardiac SPECT Imaging.
Academic Article Improved Dynamic Cardiac Phantom Based on 4D NURBS and Tagged MRI.
Academic Article Accelerated SPECT Monte Carlo Simulation Using Multiple Projection Sampling and Convolution-Based Forced Detection.
Academic Article Convolution-Based Forced Detection Monte Carlo Simulation Incorporating Septal Penetration Modeling.
Academic Article An Adaptive Approach to Decomposing Patient-Motion Tracking Data Acquired During Cardiac SPECT Imaging.
Academic Article A Robust Visual Tracking System for Patient Motion Detection in SPECT: Hardware Solutions.
Academic Article Estimation of the Rigid-Body Motion from Three-Dimensional Images Using a Generalized Center-of-Mass Points Approach.
Academic Article Feasibility of Stereo-Infrared Tracking to Monitor Patient Motion During Cardiac SPECT Imaging.
Academic Article An Assessment of a Low-Cost Visual Tracking System (VTS) to Detect and Compensate for Patient Motion during SPECT.
Academic Article An Evaluation of Iterative Reconstruction Strategies on Mediastinal Lesion Detection Using Hybrid Ga-67 SPECT Images.
Academic Article Factors Influencing Lesion Detection in SPECT Lung Images.
Academic Article The Influence of Photon Attenuation on Tumor-to-Background and Signal-to-Noise Ratios for SPECT Imaging.
Academic Article Impact of respiratory motion on the detection of small pulmonary nodules in SPECT imaging.
Academic Article Location-known-exactly human-observer ROC studies of attenuation and other corrections for SPECT lung imaging.
Academic Article A Multiclass Model Observer for Multislice-Multiview Images.
Academic Article Human-observer LROC study of lesion detection in Ga-67 SPECT images reconstructed using MAP with anatomical priors.
Academic Article Choosing anatomical-prior strength for MAP SPECT reconstruction to maximize lesion detectability.
Academic Article Regularized Fully 5D Reconstruction of Cardiac Gated Dynamic SPECT Images.
Academic Article Impact of Mismatched Detector-Blur Models on Ga SPECT Tumor Detection.
Academic Article Spillover Compensation in the Presence of Respiratory Motion Embedded in SPECT Perfusion Data.
Academic Article Effect of Non-Alignment/Alignment of Attenuation Map Without/With Emission Motion Correction in Cardiac SPECT/CT.
Academic Article Design of a Multi-Pinhole Collimator for I-123 DaTscan Imaging on Dual-Headed SPECT Systems in Combination with a Fan-Beam Collimator.
Academic Article Modeling the respiratory motion of solitary pulmonary nodules and determining the impact of respiratory motion on their detection in SPECT imaging.
Academic Article LROC Investigation of Three Strategies for Reducing the Impact of Respiratory Motion on the Detection of Solitary Pulmonary Nodules in SPECT.
Academic Article Correction of hysteretic respiratory motion in SPECT myocardial perfusion imaging: Simulation and patient studies.
Academic Article Evaluation of Rigid-Body Motion Compensation in Cardiac Perfusion SPECT Employing Polar-Map Quantification.
Academic Article Investigation of the physical effects of respiratory motion compensation in a large population of patients undergoing Tc-99m cardiac perfusion SPECT/CT stress imaging.
Academic Article Motion-compensated image reconstruction vs postreconstruction correction in respiratory-binned SPECT with standard and reduced-dose acquisitions.
Academic Article Evaluation of different respiratory gating schemes for cardiac SPECT.
Academic Article 4-D Reconstruction With Respiratory Correction for Gated Myocardial Perfusion SPECT.
Academic Article Investigation of dose reduction in cardiac perfusion SPECT via optimization and choice of the image reconstruction strategy.
Academic Article 4D non-local means post-filtering for cardiac gated SPECT.
Academic Article Improving perfusion defect detection with respiratory motion correction in cardiac SPECT at standard and reduced doses.
Academic Article Evaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT.
Academic Article Personalized Models for Injected Activity Levels in SPECT Myocardial Perfusion Imaging.
Academic Article Cardiac motion correction for improving perfusion defect detection in cardiac SPECT at standard and reduced doses of activity.
Academic Article Simulations of a Multi-Pinhole SPECT Collimator for Clinical Dopamine Transporter (DAT) Imaging.
Academic Article Retrospective fractional dose reduction in Tc-99m cardiac perfusion SPECT/CT patients: A human and model observer study.
Academic Article Primary, scatter, and penetration characterizations of parallel-hole and pinhole collimators for I-123 SPECT.
Academic Article Improving Diagnostic Accuracy in Low-Dose SPECT Myocardial Perfusion Imaging With Convolutional Denoising Networks.
Academic Article Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging.
Academic Article The clinical utilities of multi-pinhole single photon emission computed tomography.
Academic Article Inclusion of quasi-vertex views in a brain-dedicated multi-pinhole SPECT system for improved imaging performance.
Academic Article Deep learning with noise-to-noise training for denoising in SPECT myocardial perfusion imaging.
Academic Article Improvement in sampling and modulation of multiplexing with temporal shuttering of adaptable apertures in a brain-dedicated multi-pinhole SPECT system.
Academic Article A novel deep-learning-based approach for automatic reorientation of 3D cardiac SPECT images.
Academic Article Improving detection accuracy of perfusion defect in standard dose SPECT-myocardial perfusion imaging by deep-learning denoising.
Academic Article A computer program for reconstruction of images from a scanning gamma camera
Academic Article A study of irradiated bone: Part III. Scintigraphic and radiographic detection of radiogenic osteosarcomas
Academic Article KVp bootstrap sensitometry
Academic Article Experimental measurements of the scatter reduction obtained in mammography with a scanning multiple slit assembly
Academic Article Survival of auto transfused red blood cells recovered from the surgical field during cardiovascular surgery
Academic Article A study of irradiated bone: Part I. Histopathologic and physiologic changes
Academic Article Rapid digital Filtering
Academic Article Array processors: An introduction to their architecture, software, and applications in nuclear medicine
Academic Article Exposure uniformity considerations in slit radiography
Academic Article Fast count dependent digital filtering of nuclear medicine images
Academic Article Two dimensional filtering of SPECT images using the Metz and Wiener filters
Academic Article Cerebral SPECT imaging with different acquisition schemes using varying levels of multiplexing versus sensitivity in an adaptive multi-pinhole brain-dedicated scanner.
Academic Article An investigation of the stationarity of the 3D modulation transfer function
Academic Article Investigation of the modulation transfer function and the scatter fraction in conjugate view SPECT restoration filtering
Academic Article Use of non-stationary temporal Wiener filter in nuclear medicine
Academic Article Area weighted convolution interpolation for data re projection in SPECT
Academic Article Ejection fraction and heart rate determine diastolic peak filling rate at rest and during exercise
Academic Article Variation in the count-dependent Metz filter with imaging system MTF
Academic Article Interactive visual optimization of SPECT pre reconstruction filtering
Academic Article Considerations in the purchase of a nuclear medicine computer system
Academic Article Improved Performance of a Multipinhole SPECT for DAT Imaging by Increasing Number of Pinholes at the Expense of Increased Multiplexing.
Academic Article Data-driven respiratory signal estimation from temporally finely sampled projection data in conventional cardiac perfusion SPECT imaging.
Academic Article Restoration of combined conjugate images in SPECT: Comparison of a new Wiener filter and the image dependent Metz filter
Academic Article Bremsstrahlung imaging using the gamma camera: Factors affecting attenuation
Academic Article A projector, back projector, pair which accounts for the two dimensional depth and distance dependent blurring in SPECT
Academic Article Activity quantitation in SPECT: A comparison of three attenuation correction methods in combination with pre reconstruction restoration filtering
Academic Article Filtering of SPECT reconstructions made using Bellini's attenuation correction method: A comparison of three pre reconstruction filters and a post reconstruction Wiener filter
Academic Article Implementation and evaluation of an analytical solution to the photon attenuation and non-stationary resolution reconstruction problem in SPECT
Academic Article A Monte Carlo investigation of the dual photopeak window scatter correction method
Academic Article Quantitative SPECT: Verification for sources in an elliptical water phantom
Concept Single Photon Emission Computed Tomography Computed Tomography
Concept Signal-To-Noise Ratio
Academic Article The hippocampus: detailed assessment of normative two-dimensional measurements, signal intensity, and subfield conspicuity on routine 3T T2-weighted sequences.
Academic Article Cross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT.
Academic Article Dual gating myocardial perfusion SPECT denoising using a conditional generative adversarial network.
Academic Article Mesh modeling of system geometry and anatomy phantoms for realistic GATE simulations and their inclusion in SPECT reconstruction.
Academic Article The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.
Academic Article Observer studies of image quality of denoising reduced-count cardiac single photon emission computed tomography myocardial perfusion imaging by three-dimensional Gaussian post-reconstruction filtering and deep learning.
Academic Article alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation.
Academic Article Quantitative single photon emission tomography: verification for sources in an elliptical water phantom.
Academic Article Respiratory signal estimation for cardiac perfusion SPECT using deep learning.
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