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Hardy, Jeanne

One or more keywords matched the following items that are connected to Hardy, Jeanne

Item Type	Name
Academic Article	Substrate-induced conformational changes occur in all cleaved forms of caspase-6.
Academic Article	Caspase-6 latent state stability relies on helical propensity.
Academic Article	Modeling nonaqueous proton wires built from helical peptides: biased proton transfer driven by helical dipoles.
Academic Article	Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.
Academic Article	Zinc-mediated allosteric inhibition of caspase-6.
Academic Article	Discovery of an allosteric site in the caspases.
Academic Article	Searching for new allosteric sites in enzymes.
Academic Article	Robust production of a peptide library using methodological synchronization.
Academic Article	L2' loop is critical for caspase-7 active site formation.
Academic Article	Dissecting an allosteric switch in caspase-7 using chemical and mutational probes.
Academic Article	Mechanism of a genetically encoded dark-to-bright reporter for caspase activity.
Academic Article	A designed redox-controlled caspase.
Academic Article	Mechanism of zinc-mediated inhibition of caspase-9.
Academic Article	Using rigidity analysis to probe mutation-induced structural changes in proteins.
Academic Article	Structural basis of fluorescence quenching in caspase activatable-GFP.
Academic Article	Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface.
Academic Article	A tunable, modular approach to fluorescent protease-activated reporters.
Academic Article	Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules.
Concept	X-Linked Inhibitor of Apoptosis Protein
Concept	Protein Binding
Concept	Protein Transport
Concept	Protein Folding
Concept	Protein Processing, Post-Translational
Concept	Protein Interaction Mapping
Concept	Recombinant Proteins
Concept	Cyclic AMP-Dependent Protein Kinases
Concept	Protein Kinases
Concept	Mutant Proteins
Concept	Serine Proteinase Inhibitors
Concept	Protein Denaturation
Concept	Viral Proteins
Concept	Repressor Proteins
Concept	Proteins
Concept	Protein Structure, Secondary
Concept	Protein Structure, Tertiary
Concept	Protein Multimerization
Concept	Crystallography, X-Ray
Concept	Escherichia coli Proteins
Concept	Green Fluorescent Proteins
Concept	Recombinant Fusion Proteins
Concept	Bacterial Outer Membrane Proteins
Concept	Protein Stability
Concept	Viral Nonstructural Proteins
Concept	Protein Structure, Quaternary
Concept	Neoplasm Proteins
Concept	Protein Conformation
Concept	Databases, Protein
Concept	Sequence Analysis, Protein
Concept	Proto-Oncogene Proteins c-abl
Concept	Protein Engineering
Academic Article	Allosteric inhibition of the NS2B-NS3 protease from dengue virus.
Academic Article	A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.
Academic Article	Co-delivery of protein and small molecule therapeutics using nanoparticle-stabilized nanocapsules.
Academic Article	Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein.
Academic Article	Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Academic Article	Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms.
Academic Article	Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.
Academic Article	Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9.
Academic Article	The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins.
Academic Article	Phosphorylation by protein kinase A disassembles the caspase-9 core.
Academic Article	Lipogels for Encapsulation of Hydrophilic Proteins and Hydrophobic Small Molecules.
Academic Article	Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.
Academic Article	Caspase-9 CARD?:?core domain interactions require a properly formed active site.
Academic Article	Cysteine Disulfide Traps Reveal Distinct Conformational Ensembles in Dengue Virus NS2B-NS3 Protease.
Academic Article	Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis.
Academic Article	Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency.
Academic Article	Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.
Academic Article	Utilizing Inverse Emulsion Polymerization To Generate Responsive Nanogels for Cytosolic Protein Delivery.
Academic Article	Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6.
Academic Article	A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates.
Academic Article	A fluorescence-activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques.
Academic Article	Tracking exogenous intracellular casp-3 using split GFP.
Academic Article	Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.
Academic Article	Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases.
Concept	Protein Domains
Concept	Autophagy-Related Proteins
Concept	Protein Conformation, alpha-Helical
Academic Article	A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 Protease.
Academic Article	A robust fluorogenic substrate for chikungunya virus protease (nsP2) activity.
Academic Article	An NMR sample preparation case study: Considerations for the self-destructive protease caspase-6.

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Protein
Crystallography