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Dr. Donahue completed undergraduate and medical education at Washington University in St. Louis, followed by an internal medicine residency at the Hospital of the University of Pennsylvania and fellowships in cardiology and cardiac electrophysiology at the Johns Hopkins University.  After completion of his medical training in 1999, Dr. Donahue served on the medical faculty at Johns Hopkins, where he attained the rank of Associate Professor prior to his 2005 relocation to Case Western Reserve University-MetroHealth Campus.  He was promoted to Professor at Case Western in 2011.  In 2013, Dr. Donahue relocated to the University of Massachusetts Medical School to start a position as Director of Electrophysiology Research. 

Dr. Donahue’s primary research interests are the elucidation of mechanisms, and from that, the development of therapies for cardiac arrhythmias.  As a means to that end, the Donahue lab has developed several gene therapy methods and created novel animal models of cardiac arrhythmias.  The Donahue lab was first to show efficacy of gene therapy for a cardiac arrhythmia in a 12/2000 Nature Medicine publication documenting heart rate control in atrial fibrillation after atrioventricular nodal gene transfer of Gαi2.  More recently, the lab demonstrated complete elimination of post-myocardial infarction ventricular arrhythmias(Nature Medicine 12/2006) and reduction in atrial fibrillation vulnerability in porcine disease models after potassium channel and connexin gene transfer.  Ongoing interests include the investigation of mechanisms for ischemic and post-infarct ventricular arrhythmias and chronic atrial fibrillation, the development of improved gene delivery methods, and the use of these methods for arrhythmia gene therapy.

One or more keywords matched the following items that are connected to Donahue, J.
Item TypeName
Academic Article Focal modification of electrical conduction in the heart by viral gene transfer.
Academic Article Inhibitory G protein overexpression provides physiologically relevant heart rate control in persistent atrial fibrillation.
Concept Genetic Therapy
Academic Article Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction.
Academic Article Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation.
Academic Article Selective molecular potassium channel blockade prevents atrial fibrillation.
Academic Article Ventricular tachycardia from the healed myocardial infarction scar: validation of an animal model and utility of gene therapy.
Academic Article Targeted high-efficiency, homogeneous myocardial gene transfer.
Academic Article Molecular ablation of ventricular tachycardia after myocardial infarction.
Academic Article Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heart.
Academic Article Acceleration of widespread adenoviral gene transfer to intact rabbit hearts by coronary perfusion with low calcium and serotonin.
Academic Article Gene therapy approaches to ventricular tachyarrhythmias.
Academic Article Gene transfer techniques for cardiac arrhythmias.
Academic Article Gene therapy for cardiac arrhythmias.
Academic Article Gene therapy strategies for cardiac electrical dysfunction.
Academic Article Biological therapies for atrial fibrillation.
Academic Article Modification of cellular communication by gene transfer.
Academic Article Gene therapy to treat cardiovascular disease.
Academic Article Gene therapy for cardiac arrhythmias.
Academic Article Somatic gene transfer and cardiac arrhythmias: problems and prospects.
Academic Article Gene therapy for cardiac arrhythmias: a dream soon to come true?
Academic Article Biological Therapies for Atrial Fibrillation: Ready for Prime Time?
Academic Article The Use of Gene Therapy for Ablation of Atrial Fibrillation.
Academic Article Cardiac gene therapy: a call for basic methods development.
Academic Article Gene Therapy for Post-infarction Ventricular Tachycardia.
Academic Article Current state of the art for cardiac arrhythmia gene therapy.
Academic Article Preclinical efficacy and safety of KCNH2-G628S gene therapy for postoperative atrial fibrillation.
Academic Article Fusion of Anthopleurin-B to AAV2 increases specificity of cardiac gene transfer.
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