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Imbalzano, Anthony

One or more keywords matched the following properties of Imbalzano, Anthony

Property	Value
overview	Academic Background B.A. (cum laude), University of Pennsylvania, 1986 Ph.D., Harvard University, 1991 Post-doctoral Fellow, Massachusetts General Hospital, 1991-1996 Assistant Professor, Cell Biology, UMass Medical School, 1997-2002 Scholar of the Leukemia and Lymphoma Society, 1999-2004 Associate Professor, Cell Biology, UMass Medical School, 2002 - 2008 Professor, Cell Biology, UMass Medical School, 2008-2016 Professor, Biochemistry & Mol. Pharmacology, UMass Medical School, 2017- Research Mammalian SWI/SNF Chromatin Remodeling Enzymes Promote Cell Differentiation http://www.umassmed.edu/imbalzanolab/research/mammalian-swisnf-enzymes-promote-cell-differentiation/ Mammalian SWI/SNF Chromatin Remodeling Enzymes as Drivers of Cancer http://www.umassmed.edu/imbalzanolab/research/mammalian-swisnf-enzymes-as-drivers-of-cancer/ Laboratory Personnel Current Personnel http://www.umassmed.edu/imbalzanolab/lab-members/current-lab-members/ Previous Trainees http://www.umassmed.edu/imbalzanolab/lab-members/alumni/

Property

Value

overview

Academic Background

B.A. (cum laude), University of Pennsylvania, 1986
Ph.D., Harvard University, 1991
Post-doctoral Fellow, Massachusetts General Hospital, 1991-1996
Assistant Professor, Cell Biology, UMass Medical School, 1997-2002
Scholar of the Leukemia and Lymphoma Society, 1999-2004
Associate Professor, Cell Biology, UMass Medical School, 2002 - 2008
Professor, Cell Biology, UMass Medical School, 2008-2016
Professor, Biochemistry & Mol. Pharmacology, UMass Medical School, 2017-

Research

Mammalian SWI/SNF Chromatin Remodeling Enzymes Promote Cell Differentiation
http://www.umassmed.edu/imbalzanolab/research/mammalian-swisnf-enzymes-promote-cell-differentiation/

Mammalian SWI/SNF Chromatin Remodeling Enzymes as Drivers of Cancer
http://www.umassmed.edu/imbalzanolab/research/mammalian-swisnf-enzymes-as-drivers-of-cancer/

Laboratory Personnel

Current Personnel
http://www.umassmed.edu/imbalzanolab/lab-members/current-lab-members/

Previous Trainees
http://www.umassmed.edu/imbalzanolab/lab-members/alumni/

One or more keywords matched the following items that are connected to Imbalzano, Anthony

Item Type	Name
Academic Article	RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling.
Academic Article	Repression and activation by multiprotein complexes that alter chromatin structure.
Academic Article	Activator-dependent regulation of transcriptional pausing on nucleosomal templates.
Academic Article	Energy-dependent chromatin remodelers: complex complexes and their components.
Academic Article	Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1.
Academic Article	Human SWI/SNF nucleosome remodeling activity is partially inhibited by linker histone H1.
Academic Article	Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation.
Academic Article	Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.
Academic Article	Phosphorylation of linker histones regulates ATP-dependent chromatin remodeling enzymes.
Academic Article	The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture.
Academic Article	Repositioning of muscle-specific genes relative to the periphery of SC-35 domains during skeletal myogenesis.
Academic Article	p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci.
Academic Article	Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme.
Academic Article	MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex.
Academic Article	Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes.
Academic Article	Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region.
Academic Article	HMGN1 is dispensable for myogenesis and adipogenesis.
Academic Article	Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response.
Academic Article	Mammalian SWI-SNF complexes contribute to activation of the hsp70 gene.
Academic Article	Functional delineation of three groups of the ATP-dependent family of chromatin remodeling enzymes.
Academic Article	BRG-1 is required for RB-mediated cell cycle arrest.
Academic Article	Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction.
Academic Article	Myogenin and the SWI/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis.
Academic Article	Chromatin remodeling by SWI/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter.
Academic Article	Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice.
Academic Article	SWI/SNF chromatin remodeling ATPase Brm regulates the differentiation of early retinal stem cells/progenitors by influencing Brn3b expression and Notch signaling.
Academic Article	Phenotypic transcription factors epigenetically mediate cell growth control.
Academic Article	MyoD can induce cell cycle arrest but not muscle differentiation in the presence of dominant negative SWI/SNF chromatin remodeling enzymes.
Academic Article	The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells.
Academic Article	Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression.
Academic Article	Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function.
Academic Article	The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes.
Academic Article	Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments.
Academic Article	Chromatin immunoprecipitation assay for tissue-specific genes using early-stage mouse embryos.
Academic Article	Separation of primary structural components conferring autoregulation, transactivation, and DNA-binding properties to the herpes simplex virus transcriptional regulatory protein ICP4.
Academic Article	An improved restriction enzyme accessibility assay for analyzing changes in chromatin structure in samples of limited cell number.
Academic Article	Chd2 interacts with H3.3 to determine myogenic cell fate.
Academic Article	Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase d catalytic subunit gene, POLD1.
Academic Article	Unfolding heterochromatin for replication.
Academic Article	Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections.
Academic Article	Oncogenic targeting of BRM drives malignancy through C/EBP?-dependent induction of a5 integrin.
Academic Article	Functional properties of ATP-dependent chromatin remodeling enzymes.
Academic Article	Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes.
Academic Article	Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor.
Academic Article	SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation.
Academic Article	Snf5 tumor suppressor couples chromatin remodeling, checkpoint control, and chromosomal stability.
Academic Article	Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling.
Academic Article	Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1.
Academic Article	The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes.
Academic Article	Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers.
Academic Article	Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity.
Academic Article	The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling.
Academic Article	Interaction of papillomavirus E2 protein with the Brm chromatin remodeling complex leads to enhanced transcriptional activation.
Academic Article	The Chd family of chromatin remodelers.
Academic Article	A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype.
Academic Article	Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling.
Academic Article	Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation.
Academic Article	The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression.
Academic Article	SWI/SNF-independent nuclease hypersensitivity and an increased level of histone acetylation at the P1 promoter accompany active transcription of the bone master gene Runx2.
Academic Article	SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.
Academic Article	Chromatin accessibility and transcription factor binding at the PPAR?2 promoter during adipogenesis is protein kinase A-dependent.
Academic Article	Dicer is required for the formation of white but not brown adipose tissue.
Academic Article	Isolation of nuclei from skeletal muscle satellite cells and myofibers for use in chromatin immunoprecipitation assays.
Academic Article	Protein arginine methyltransferase 5 (Prmt5) promotes gene expression of peroxisome proliferator-activated receptor ?2 (PPAR?2) and its target genes during adipogenesis.
Academic Article	Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice.
Academic Article	The Scaffold attachment factor b1 (Safb1) regulates myogenic differentiation by facilitating the transition of myogenic gene chromatin from a repressed to an activated state.
Academic Article	The role of ICP4 repressor activity in temporal expression of the IE-3 and latency-associated transcript promoters during HSV-1 infection.
Concept	Body Temperature Regulation
Concept	Down-Regulation
Concept	Chromatin Immunoprecipitation
Concept	Up-Regulation
Concept	Chromatin
Concept	Gene Expression Regulation, Developmental
Concept	Gene Expression Regulation
Concept	Gene Expression Regulation, Viral
Concept	Gene Expression Regulation, Enzymologic
Concept	Gene Expression Regulation, Neoplastic
Concept	Chromatin Assembly and Disassembly
Academic Article	BRG1, a SWI/SNF chromatin remodeling enzyme ATPase, is required for maintenance of nuclear shape and integrity.
Academic Article	The PPAR? locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner.
Academic Article	The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter.
Academic Article	Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development.
Academic Article	Spatial re-organization of myogenic regulatory sequences temporally controls gene expression.
Academic Article	Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme.
Academic Article	The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.
Academic Article	Brg1 Controls the Expression of Pax7 to Promote Viability and Proliferation of Mouse Primary Myoblasts.
Academic Article	Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.
Academic Article	C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization.
Academic Article	Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells.
Academic Article	Promoter-enhancer looping at the PPAR?2 locus during adipogenic differentiation requires the Prmt5 methyltransferase.
Academic Article	Targeting the chromatin remodeling enzyme BRG1 increases the efficacy of chemotherapy drugs in breast cancer cells.
Academic Article	SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells.
Academic Article	RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.
Academic Article	The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation.
Academic Article	Identifying Nuclear Matrix-Attached DNA Across the Genome.
Academic Article	Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer.
Academic Article	The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer.
Academic Article	Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition.
Academic Article	Temporal regulation of chromatin during myoblast differentiation.
Academic Article	Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer.
Academic Article	RUNX1-dependent mechanisms in biological control and dysregulation in cancer.
Academic Article	Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer.
Academic Article	Calcineurin Broadly Regulates the Initiation of Skeletal Muscle-Specific Gene Expression by Binding Target Promoters and Facilitating the Interaction of the SWI/SNF Chromatin Remodeling Enzyme.
Academic Article	CK2-Dependent Phosphorylation of the Brg1 Chromatin Remodeling Enzyme Occurs during Mitosis.
Academic Article	Regulation of the Mammalian SWI/SNF Family of Chromatin Remodeling Enzymes by Phosphorylation during Myogenesis.
Academic Article	The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.
Academic Article	Differential requirements for different subfamilies of the mammalian SWI/SNF chromatin remodeling enzymes in myoblast cell cycle progression and expression of the Pax7 regulator.
Academic Article	Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Cell and Tissue Structure, Function, and Phenotype.
Academic Article	Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle.
Academic Article	Protein arginine methyltransferase 5 (Prmt5) localizes to chromatin loop anchors and modulates expression of genes at TAD boundaries during early adipogenesis.
Academic Article	Regulation of the Wnt signaling pathway during myogenesis by the mammalian SWI/SNF ATPase BRG1.
Academic Article	Differential Contributions of mSWI/SNF Chromatin Remodeler Sub-Families to Myoblast Differentiation.

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Chromatin
Regulation