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Academic Background

B.A. Wellesley College
Ph. D.Tufts University School of Medicine
Postdoctoral training at Massachusetts Institute of Technology

Dr. Trudy Morrison

Mechanisms of Paramyxovirus Membrane Fusion
Assembly of Paramyxoviruses
Development of Virus Vaccines

My laboratory is exploring the molecular mechanisms of paramyxovirus entry into susceptible cells and the assembly and release of infectious virus from infected cells. Paramyxoviruses are simple negative-stranded, enveloped RNA viruses. The two viral glycoproteins, the hemagglutinin-neuraminidase (HN) protein and the fusion (F) protein, mediate entry of the virus into cells. The HN protein is the virus attachment protein and the F protein directly mediates the membrane fusion required for virus penetration. However, the HN protein is required to activate the fusion activity of the F protein. Using Newcastle disease virus as a model paramyxovirus, my laboratory is exploring the molecular mechanisms involved in the activation of the fusion protein and the requirements for the conformational changes in the F protein required to mediate membrane fusion.

Release of progeny paramyxoviruses from infected cells requires the assembly of the structural components of the virion, the viral glycoproteins, the matrix protein, and the ribonucleoprotein core, followed by the budding of mature virus from surfaces of infected cells. We are exploring the protein interactions required for the formation of assembly complexes, the cell domains involved in virus assembly, and the host cell contributions to virus assembly and release.

My laboratory is also exploring the potential of virus-like particles as vaccines for different paramyxoviruses.

One or more keywords matched the following items that are connected to Morrison, Trudy
Item TypeName
Academic Article Detection of an interaction between the HN and F proteins in Newcastle disease virus-infected cells.
Academic Article The role of leucine residues in the structure and function of a leucine zipper peptide inhibitor of paramyxovirus (NDV) fusion.
Academic Article Interaction of peptides with sequences from the Newcastle disease virus fusion protein heptad repeat regions.
Academic Article A single amino acid change in the Newcastle disease virus fusion protein alters the requirement for HN protein in fusion.
Academic Article Role of cotranslational disulfide bond formation in the folding of the hemagglutinin-neuraminidase protein of Newcastle disease virus.
Academic Article Assembly of viral membranes. I. Association of vesicular stomatitis virus membrane proteins and membranes in a cell-free system.
Academic Article Analysis of a peptide inhibitor of paramyxovirus (NDV) fusion using biological assays, NMR, and molecular modeling.
Academic Article Role of carbohydrate processing and calnexin binding in the folding and activity of the HN protein of Newcastle disease virus.
Academic Article Evidence for mixed membrane topology of the newcastle disease virus fusion protein.
Academic Article Assembly of viral membranes: maturation of the vesicular stomatitis virus glycoprotein in the presence of tunicamycin.
Academic Article Structure and function of a paramyxovirus fusion protein.
Academic Article Interacting domains of the HN and F proteins of newcastle disease virus.
Academic Article Inhibition of receptor binding stabilizes Newcastle disease virus HN and F protein-containing complexes.
Academic Article The three faces of paramyxovirus attachment proteins.
Academic Article Incorporation of functional HN-F glycoprotein-containing complexes into newcastle disease virus is dependent on cholesterol and membrane lipid raft integrity.
Academic Article Assembly and biological and immunological properties of Newcastle disease virus-like particles.
Academic Article Avian cells expressing the Newcastle disease virus hemagglutinin-neuraminidase protein are resistant to Newcastle disease virus infection.
Academic Article Assembly and immunological properties of Newcastle disease virus-like particles containing the respiratory syncytial virus F and G proteins.
Academic Article The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein.
Academic Article Assembly of viral membranes: nature of the association of vesicular stomatitis virus proteins to membranes.
Academic Article Conformational change in a viral glycoprotein during maturation due to disulfide bond disruption.
Academic Article Cytochalasin D accelerates the release of Newcastle disease virus from infected cells.
Academic Article Translation of bacteriophage Q RNA by cytoplasmic extracts of mammalian cells.
Academic Article Mutational changes in the vesicular stomatitis virus glycoprotein affect the requirement of carbohydrate in morphogenesis.
Academic Article Characterization of the soluble glycoprotein released from vesicular stomatitis virus-infected cells.
Academic Article Synthesis of Newcastle disease virus polypeptides in a wheat germ cell-free system.
Academic Article Role of the cytoplasmic domain of the Newcastle disease virus fusion protein in association with lipid rafts.
Academic Article Fatty acid modification of Newcastle disease virus glycoproteins.
Academic Article Synthesis, stability, and cleavage of Newcastle disease virus glycoproteins in the absence of glycosylation.
Academic Article Mutational analysis of the leucine zipper motif in the Newcastle disease virus fusion protein.
Academic Article Relationships among the polypeptides of Newcastle disease virus.
Academic Article The role of the individual cysteine residues in the formation of the mature, antigenic HN protein of Newcastle disease virus.
Academic Article The fusion promotion activity of the NDV HN protein does not correlate with neuraminidase activity.
Academic Article Characterization of an alternate form of Newcastle disease virus fusion protein.
Academic Article Requirements for the assembly and release of Newcastle disease virus-like particles.
Academic Article Integrity of membrane lipid rafts is necessary for the ordered assembly and release of infectious Newcastle disease virus particles.
Academic Article Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein.
Academic Article Mature, cell-associated HN protein of Newcastle disease virus exists in two forms differentiated by posttranslational modifications.
Academic Article Newcastle disease virus: propagation, quantification, and storage.
Academic Article Overexpression of thiol/disulfide isomerases enhances membrane fusion directed by the Newcastle disease virus fusion protein.
Academic Article Role of thiol/disulfide exchange in newcastle disease virus entry.
Academic Article Newcastle disease virus-like particles containing respiratory syncytial virus G protein induced protection in BALB/c mice, with no evidence of immunopathology.
Academic Article Structure and assembly of a paramyxovirus matrix protein.
Academic Article Long-term and memory immune responses in mice against Newcastle disease virus-like particles containing respiratory syncytial virus glycoprotein ectodomains.
Academic Article The nucleotide sequence of the gene encoding the Newcastle disease virus membrane protein and comparisons of membrane protein sequences.
Academic Article Nucleotide sequence of the gene encoding the Newcastle disease virus hemagglutinin-neuraminidase protein and comparisons of paramyxovirus hemagglutinin-neuraminidase protein sequences.
Academic Article Structure, function, and intracellular processing of paramyxovirus membrane proteins.
Academic Article Nucleotide sequence of the gene encoding the Newcastle disease virus fusion protein and comparisons of paramyxovirus fusion protein sequences.
Academic Article T7 protein synthesis in F' episome-containing cells: assignment of specific proteins to three translational groups.
Academic Article Intracellular processing of the vesicular stomatitis virus glycoprotein and the Newcastle disease virus hemagglutinin-neuraminidase glycoprotein.
Academic Article The role of individual oligosaccharide chains in the activities of the HN glycoprotein of Newcastle disease virus.
Academic Article Mutations in the cytoplasmic domain of the fusion glycoprotein of Newcastle disease virus depress syncytia formation.
Academic Article Modulation of the activities of HN protein of Newcastle disease virus by nonconserved cysteine residues.
Academic Article The attachment function of the Newcastle disease virus hemagglutinin-neuraminidase protein can be separated from fusion promotion by mutation.
Concept Hemagglutinins, Viral
Concept Genes, Viral
Concept RNA, Viral
Concept Antibodies, Viral
Concept Viral Plaque Assay
Concept Viral Proteins
Concept DNA, Viral
Concept Viral Core Proteins
Concept Viral Structural Proteins
Concept Viral Vaccines
Concept Antigens, Viral
Concept Viral Matrix Proteins
Concept Viral Fusion Proteins
Concept Peptide Hydrolases
Concept Viral Envelope Proteins
Academic Article Modification of the respiratory syncytial virus f protein in virus-like particles impacts generation of B cell memory.
Academic Article Meeting report VLPNPV: Session 3: Immune responses.
Academic Article A chimeric EBV gp350/220-based VLP replicates the virion B-cell attachment mechanism and elicits long-lasting neutralizing antibodies in mice.
Academic Article Murine immune responses to virus-like particle-associated pre- and postfusion forms of the respiratory syncytial virus F protein.
Academic Article Protein conformation in a vaccine matters.
Academic Article Cotton rat immune responses to virus-like particles containing the pre-fusion form of respiratory syncytial virus fusion protein.
Academic Article The importance of RSV F protein conformation in VLPs in stimulation of neutralizing antibody titers in mice previously infected with RSV.
Academic Article A multifaceted approach to RSV vaccination.
Academic Article Efficacy of a respiratory syncytial virus vaccine candidate in a maternal immunization model.
Academic Article Effect of Previous Respiratory Syncytial Virus Infection on Murine Immune Responses to F and G Protein-Containing Virus-Like Particles.
Academic Article Alternative Virus-Like Particle-Associated Prefusion F Proteins as Maternal Vaccines for Respiratory Syncytial Virus.
Academic Article Evolution of protection after maternal immunization for respiratory syncytial virus in cotton rats.
Academic Article Correlative outcomes of maternal immunization against RSV in cotton rats.
Academic Article The Respiratory Syncytial Virus (RSV) G Protein Enhances the Immune Responses to the RSV F Protein in an Enveloped Virus-Like Particle Vaccine Candidate.
Academic Article Development of Respiratory Syncytial Virus Vaccine Candidates for the Elderly.
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  • Viral
  • Proteases