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Schiffer, Celia
One or more keywords matched the following items that are connected to Schiffer, Celia
Item TypeName
Academic Article Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors. Cancer and Leukemia Group B.
Academic Article Risk factors for severe neuropsychiatric toxicity in patients receiving interferon alfa-2b and low-dose cytarabine for chronic myelogenous leukemia: analysis of Cancer and Leukemia Group B 9013.
Academic Article Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site.
Academic Article Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance.
Academic Article The maturation of dendritic cells results in postintegration inhibition of HIV-1 replication.
Academic Article Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease.
Academic Article Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor.
Academic Article Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
Academic Article Design of HIV-1 protease inhibitors active on multidrug-resistant virus.
Academic Article PTEN enters the nucleus by diffusion.
Academic Article Crystallization of human thymidylate synthase.
Academic Article Co-evolution of nelfinavir-resistant HIV-1 protease and the p1-p6 substrate.
Academic Article Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease.
Academic Article Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling.
Academic Article Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres.
Academic Article Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3.
Academic Article Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Academic Article Viral protease inhibitors.
Academic Article Toward the design of mutation-resistant enzyme inhibitors: further evaluation of the substrate envelope hypothesis.
Academic Article Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces.
Academic Article Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.
Academic Article Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article The effect of clade-specific sequence polymorphisms on HIV-1 protease activity and inhibitor resistance pathways.
Academic Article Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones.
Academic Article Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease.
Academic Article Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope.
Academic Article The challenge of developing robust drugs to overcome resistance.
Academic Article Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes.
Academic Article First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.
Academic Article Context surrounding processing sites is crucial in determining cleavage rate of a subset of processing sites in HIV-1 Gag and Gag-Pro-Pol polyprotein precursors by viral protease.
Academic Article Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A.
Academic Article The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
Academic Article Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket.
Academic Article Nitric oxide-mediated inhibition of Hdm2-p53 binding.
Academic Article Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy.
Academic Article Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments.
Academic Article Covariation of amino acid positions in HIV-1 protease.
Academic Article Cigarette smoking and risk of acute leukemia: associations with morphology and cytogenetic abnormalities in bone marrow.
Academic Article Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease.
Academic Article Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance.
Academic Article Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate.
Academic Article Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity.
Academic Article N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure.
Academic Article Hydrophobic sliding: a possible mechanism for drug resistance in human immunodeficiency virus type 1 protease.
Academic Article Crystal structure of lysine sulfonamide inhibitor reveals the displacement of the conserved flap water molecule in human immunodeficiency virus type 1 protease.
Academic Article Mass spectrometry analysis of HIV-1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivity.
Academic Article Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6.
Academic Article Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.
Academic Article Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance.
Academic Article Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
Academic Article Therapeutic targeting of C-terminal binding protein in human cancer.
Academic Article Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.
Academic Article Three residues in HIV-1 matrix contribute to protease inhibitor susceptibility and replication capacity.
Academic Article TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors.
Academic Article Decomposing the energetic impact of drug-resistant mutations: the example of HIV-1 protease-DRV binding.
Academic Article Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.
Academic Article Collinearity of protease mutations in HIV-1 samples with high-level protease inhibitor class resistance.
Academic Article Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
Academic Article Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain.
Academic Article Interview with Celia Schiffer.
Academic Article Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.
Academic Article Prolonged subcutaneous administration of recombinant alpha 2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: effect on remission duration and survival: Cancer and Leukemia Group B study 8583.
Concept pol Gene Products, Human Immunodeficiency Virus
Concept Humans
Concept Human Growth Hormone
Concept Influenza, Human
Concept Enterovirus D, Human
Concept gag Gene Products, Human Immunodeficiency Virus
Concept Human T-lymphotropic virus 1
Concept Chromosomes, Human, Pair 21
Concept Chromosomes, Human, Pair 8
Concept vif Gene Products, Human Immunodeficiency Virus
Academic Article Influenza virus drug resistance: a time-sampled population genetics perspective.
Academic Article Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.
Academic Article A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid.
Academic Article Testing the substrate-envelope hypothesis with designed pairs of compounds.
Academic Article Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
Academic Article Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
Academic Article HIV-1 protease-substrate coevolution in nelfinavir resistance.
Academic Article Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease.
Academic Article A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif.
Academic Article Development of a Novel Screening Strategy Designed to Discover a New Class of HIV Drugs.
Academic Article The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Academic Article Structure-guided design of a high affinity inhibitor to human CtBP.
Academic Article REdiii: a pipeline for automated structure solution.
Academic Article Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G.
Academic Article A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro.
Academic Article Structural basis for mutation-induced destabilization of profilin 1 in ALS.
Academic Article Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.
Academic Article A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance.
Academic Article Inhibition of APOBEC3G activity impedes double-stranded DNA repair.
Academic Article Improving Viral Protease Inhibitors to Counter Drug Resistance.
Academic Article Dengue Protease Substrate Recognition: Binding of the Prime Side.
Academic Article Prototypical Recombinant Multi-Protease-Inhibitor-Resistant Infectious Molecular Clones of Human Immunodeficiency Virus Type 1.
Academic Article Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions.
Academic Article Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.
Academic Article Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side.
Academic Article Interdependence of Inhibitor Recognition in HIV-1 Protease.
Academic Article Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants.
Academic Article Elucidating the Interdependence of Drug Resistance from Combinations of Mutations.
Academic Article Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.
Academic Article Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness.
Academic Article Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions.
Academic Article Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.
Academic Article Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease.
Academic Article T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response.
Academic Article A comparative study of two different doses of cytarabine for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B.
Academic Article Risk factors for high-dose cytarabine neurotoxicity: an analysis of a cancer and leukemia group B trial in patients with acute myeloid leukemia.
Academic Article Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B.
Academic Article A phase I trial of carboplatin and etoposide given as continuous infusions to adults with leukemia.
Academic Article Postremission therapy in older patients with de novo acute myeloid leukemia: a randomized trial comparing mitoxantrone and intermediate-dose cytarabine with standard-dose cytarabine.
Academic Article Assembly of human C-terminal binding protein (CtBP) into tetramers.
Academic Article Mavyret: A Pan-Genotypic Combination Therapy for the Treatment of Hepatitis C InfectionPublished as part of the Biochemistry series "Biochemistry to Bedside".
Academic Article A call to arms: Unifying the fight against resistance.
Academic Article Structural Analysis of the Active Site and DNA Binding of Human Cytidine Deaminase APOBEC3B.
Academic Article Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.
Academic Article Granulocyte-macrophage colony-stimulating factor after initial chemotherapy for elderly patients with primary acute myelogenous leukemia. Cancer and Leukemia Group B.
Academic Article Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia.
Academic Article Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
Academic Article Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors.
Academic Article APOBEC3s: DNA-editing human cytidine deaminases.
Academic Article NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations.
Academic Article Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Academic Article Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints.
Academic Article HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope.
Academic Article Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Academic Article Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA.
Academic Article Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease.
Academic Article Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures.
Academic Article Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors.
Academic Article Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere.
Academic Article A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction.
Academic Article Crystal Structure of a Soluble APOBEC3G Variant Suggests ssDNA to Bind in a Channel that Extends between the Two Domains.
Academic Article Cryo-EM structure of CtBP2 confirms tetrameric architecture.
Academic Article Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Academic Article Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Academic Article NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).
Academic Article Inhibiting HTLV-1 Protease: A Viable Antiviral Target.
Academic Article Introduction: Drug Resistance.
Academic Article Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit.
Academic Article Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s.
Academic Article Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.
Academic Article Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.
Academic Article Viral proteases: Structure, mechanism and inhibition.
Academic Article Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y.
Academic Article Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.
Academic Article Call for Papers: Drug Resistance in Infectious Diseases and Beyond.
Academic Article Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks.
Academic Article HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector.
Academic Article Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms.
Academic Article Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Academic Article Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2.
Academic Article Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease.
Academic Article Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants.
Academic Article Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance.
Academic Article Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses.
Academic Article Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease.
Academic Article Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia.
Academic Article Chronic lymphocytic leukemia: recommendations.
Academic Article Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Academic Article Report of an international working group to standardize response criteria for myelodysplastic syndromes.
Academic Article Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group.
Academic Article Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance.
Academic Article Myelodysplastic syndromes standardized response criteria: further definition.
Academic Article Increasing intracellular dNTP levels improves prime editing efficiency.
Academic Article FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques.
Academic Article Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance.
Academic Article Direct delivery of Cas-embedded cytosine base editors as ribonucleoprotein complexes for efficient and accurate editing of clinically relevant targets.
Academic Article Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease.
Academic Article Next generation?APOBEC3 inhibitors: optimally designed for potency and nuclease stability.
Academic Article Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography.
Academic Article Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50.
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