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Ali, Akbar

One or more keywords matched the following items that are connected to Ali, Akbar

Item Type	Name
Academic Article	Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication.
Academic Article	Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis.
Academic Article	Additivity in the analysis and design of HIV protease inhibitors.
Academic Article	P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes.
Academic Article	Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones.
Academic Article	First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.
Academic Article	Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
Academic Article	The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
Academic Article	Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands.
Academic Article	HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.
Academic Article	Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
Academic Article	Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.
Concept	Protein Binding
Concept	HSP70 Heat-Shock Proteins
Concept	Protein Kinase Inhibitors
Concept	Carrier Proteins
Concept	Intracellular Signaling Peptides and Proteins
Concept	Serine Proteinase Inhibitors
Concept	Viral Proteins
Concept	Protein Structure, Tertiary
Concept	Viral Structural Proteins
Concept	Crystallography
Concept	Crystallography, X-Ray
Concept	Viral Nonstructural Proteins
Concept	Proto-Oncogene Proteins c-fos
Concept	Protein Conformation
Academic Article	Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.
Academic Article	Testing the substrate-envelope hypothesis with designed pairs of compounds.
Academic Article	Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
Academic Article	Structural analysis of asunaprevir resistance in HCV NS3/4A protease.
Academic Article	Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.
Academic Article	P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.
Academic Article	Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172.
Academic Article	Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease.
Academic Article	Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side.
Academic Article	Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants.
Academic Article	Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease.
Academic Article	Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
Academic Article	HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope.
Academic Article	Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.
Academic Article	Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir.
Academic Article	Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors.
Academic Article	Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere.
Academic Article	Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Academic Article	Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188.
Academic Article	Inhibiting HTLV-1 Protease: A Viable Antiviral Target.
Academic Article	Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Academic Article	Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease.
Academic Article	HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues.
Academic Article	Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance.
Academic Article	Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease.

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Protein
Crystallography