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Wang, Jennifer
One or more keywords matched the following properties of Wang, Jennifer
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Biographical Information

Post-graduate training

  • Internal Medicine Residency, Oregon Health Sciences University
  • Fellowship, Infectious Disease, University of California, San Diego

Board certification

  • Diplomate in Internal Medicine, American Board of Internal Medicine
  • Diplomate in Infectious Disease, American Board of Internal Medicine

Research interests

My laboratory also investigates viral activation of pattern recognition receptors and downstream pathways in various host cells and models. Recently we have examined how innate immune responses contribute to autoimmune disease processes, in particular how activation of inflammatory pathways and type I interferon can lead to type 1 diabetes (T1D). T1D is an autoimmune disease that destroys the insulin-producing cells of the pancreas. Enteroviruses including Coxsackie B virus (CVB) have been implicated in the etiology of T1D and polymorphisms in viral sensors have been associated with various autoimmune phenotypes including T1D. We demonstrated that CVB can activate type I interferon via Toll-like receptor 7 as well as through MDA5. We have used mice engrafted with human islets to study the effects of virus challenge on beta cells and development of diabetes. We also generated IFNAR1 knockout rats that are protected from virus-triggered T1D to better understand the links between innate and adaptive immunity and the development of diabetes. Finally, we are examining drivers of inflammation in human stem cell-derived islets to better understand the pathogenesis of T1D.
One or more keywords matched the following items that are connected to Wang, Jennifer
Item TypeName
Academic Article The role of toll-like receptors in herpes simplex infection in neonates.
Academic Article CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages.
Academic Article Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2.
Academic Article Bursal sporotrichosis: case report and review.
Academic Article Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA.
Academic Article Toll-like receptor-mediated activation of neutrophils by influenza A virus.
Academic Article The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution.
Academic Article Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence.
Academic Article LPLUNC1 modulates innate immune responses to Vibrio cholerae.
Academic Article Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus.
Academic Article Gene expression profiling detects patterns of human macrophage responses following Mycobacterium tuberculosis infection.
Academic Article Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis.
Academic Article Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
Academic Article Toll like receptors and viruses.
Academic Article Innate immunity to respiratory viruses.
Academic Article Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA.
Academic Article MDA5 and MAVS mediate type I interferon responses to coxsackie B virus.
Academic Article A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus.
Academic Article Role of specific innate immune responses in herpes simplex virus infection of the central nervous system.
Academic Article Plasmacytoid dendritic cell interferon-a production to R-848 stimulation is decreased in male infants.
Concept Herpesvirus 2, Human
Concept Humans
Concept Herpesvirus 1, Human
Concept Influenza, Human
Concept Parainfluenza Virus 3, Human
Concept Herpesvirus 3, Human
Concept Enterovirus B, Human
Academic Article Dicer's role as an antiviral: still an enigma.
Academic Article Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients.
Academic Article Influenza virus drug resistance: a time-sampled population genetics perspective.
Academic Article Increased survival in B-cell-deficient mice during experimental cerebral malaria suggests a role for circulating immune complexes.
Academic Article Spectrum and mechanisms of inflammasome activation by chitosan.
Academic Article TRIM13 is a negative regulator of MDA5-mediated type I interferon production.
Academic Article Viral infection of engrafted human islets leads to diabetes.
Academic Article Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps.
Academic Article Influenza A virus preferentially snatches noncoding RNA caps.
Academic Article A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance.
Academic Article Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.
Academic Article Recrudescence of Plasmodium falciparum in a Primigravida After Nearly 3 Years of Latency.
Academic Article Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes.
Academic Article Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.
Academic Article Potential role of type I interferon in the pathogenic process leading to type 1 diabetes.
Academic Article Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness.
Academic Article A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection.
Academic Article The role of platelets in mediating a response to human influenza infection.
Academic Article Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.
Academic Article Proteomic and Transcriptional Profiles of Human Stem Cell-Derived ? Cells Following Enteroviral Challenge.
Academic Article SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Academic Article Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study.
Academic Article Remdesivir for the Treatment of Covid-19 - Final Report.
Academic Article Coxsackievirus B Type 4 Infection in ? Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing.
Academic Article Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19.
Academic Article Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Academic Article High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro.
Academic Article SARS-CoV-2 Initiates Programmed Cell Death in Platelets.
Academic Article Human nasal wash RNA-Seq reveals distinct cell-specific innate immune responses in influenza versus SARS-CoV-2.
Academic Article Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial.
Academic Article Type I IFN-Driven Immune Cell Dysregulation in Rat Autoimmune Diabetes.
Academic Article Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y.
Academic Article Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks.
Academic Article Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial.
Academic Article An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes.
Academic Article Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Academic Article Dysregulated pulmonary inflammatory responses exacerbate the outcome of secondary aspergillosis following influenza.
Academic Article SARS-CoV-2 RNA and Nucleocapsid Antigen Are Blood Biomarkers Associated With Severe Disease Outcomes That Improve in Response to Remdesivir.
Academic Article Increasing intracellular dNTP levels improves prime editing efficiency.
Academic Article Time to Sustained Recovery Among Outpatients With COVID-19 Receiving Montelukast vs Placebo: The ACTIV-6 Randomized Clinical Trial.
Academic Article Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases.
Academic Article CRISPR editing of candidate host factors that impact influenza A virus infection.
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