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Wang, Jennifer

One or more keywords matched the following properties of Wang, Jennifer

Property	Value
overview	Biographical Information Post-graduate training Internal Medicine Residency, Oregon Health Sciences University Fellowship, Infectious Disease, University of California, San Diego Board certification Diplomate in Internal Medicine, American Board of Internal Medicine Diplomate in Infectious Disease, American Board of Internal Medicine Research interests My laboratory also investigates viral activation of pattern recognition receptors and downstream pathways in various host cells and models. Recently we have examined how innate immune responses contribute to autoimmune disease processes, in particular how activation of inflammatory pathways and type I interferon can lead to type 1 diabetes (T1D). T1D is an autoimmune disease that destroys the insulin-producing cells of the pancreas. Enteroviruses including Coxsackie B virus (CVB) have been implicated in the etiology of T1D and polymorphisms in viral sensors have been associated with various autoimmune phenotypes including T1D. We demonstrated that CVB can activate type I interferon via Toll-like receptor 7 as well as through MDA5. We have used mice engrafted with human islets to study the effects of virus challenge on beta cells and development of diabetes. We also generated IFNAR1 knockout rats that are protected from virus-triggered T1D to better understand the links between innate and adaptive immunity and the development of diabetes. Finally, we are examining drivers of inflammation in human stem cell-derived islets to better understand the pathogenesis of T1D.

Property

Value

overview

Biographical Information

Post-graduate training

Internal Medicine Residency, Oregon Health Sciences University
Fellowship, Infectious Disease, University of California, San Diego

Board certification

Diplomate in Internal Medicine, American Board of Internal Medicine
Diplomate in Infectious Disease, American Board of Internal Medicine

Research interests

My laboratory also investigates viral activation of pattern recognition receptors and downstream pathways in various host cells and models. Recently we have examined how innate immune responses contribute to autoimmune disease processes, in particular how activation of inflammatory pathways and type I interferon can lead to type 1 diabetes (T1D). T1D is an autoimmune disease that destroys the insulin-producing cells of the pancreas. Enteroviruses including Coxsackie B virus (CVB) have been implicated in the etiology of T1D and polymorphisms in viral sensors have been associated with various autoimmune phenotypes including T1D. We demonstrated that CVB can activate type I interferon via Toll-like receptor 7 as well as through MDA5. We have used mice engrafted with human islets to study the effects of virus challenge on beta cells and development of diabetes. We also generated IFNAR1 knockout rats that are protected from virus-triggered T1D to better understand the links between innate and adaptive immunity and the development of diabetes. Finally, we are examining drivers of inflammation in human stem cell-derived islets to better understand the pathogenesis of T1D.

One or more keywords matched the following items that are connected to Wang, Jennifer

Item Type	Name
Academic Article	CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages.
Academic Article	Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2.
Academic Article	Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA.
Academic Article	Toll-like receptor-mediated activation of neutrophils by influenza A virus.
Academic Article	Antiviral responses: different roles for different tolls.
Academic Article	Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists.
Academic Article	Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence.
Academic Article	LPLUNC1 modulates innate immune responses to Vibrio cholerae.
Academic Article	The combination of early and rapid type I IFN, IL-1a, and IL-1? production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses.
Academic Article	Gene expression profiling detects patterns of human macrophage responses following Mycobacterium tuberculosis infection.
Academic Article	Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
Academic Article	Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection.
Academic Article	Innate immunity to respiratory viruses.
Academic Article	Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA.
Academic Article	MDA5 and MAVS mediate type I interferon responses to coxsackie B virus.
Academic Article	Role of specific innate immune responses in herpes simplex virus infection of the central nervous system.
Academic Article	Plasmacytoid dendritic cell interferon-a production to R-848 stimulation is decreased in male infants.
Concept	Enzyme-Linked Immunosorbent Assay
Concept	Organoids
Concept	Immunity, Innate
Concept	Adjuvants, Immunologic
Concept	Immunohistochemistry
Academic Article	Dicer's role as an antiviral: still an enigma.
Academic Article	Increased survival in B-cell-deficient mice during experimental cerebral malaria suggests a role for circulating immune complexes.
Academic Article	Spectrum and mechanisms of inflammasome activation by chitosan.
Academic Article	Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps.
Academic Article	A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats.
Academic Article	Potential role of type I interferon in the pathogenic process leading to type 1 diabetes.
Academic Article	Autophagy and innate immunity to viruses
Academic Article	Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study.
Academic Article	Human nasal wash RNA-Seq reveals distinct cell-specific innate immune responses in influenza versus SARS-CoV-2.
Academic Article	Type I IFN-Driven Immune Cell Dysregulation in Rat Autoimmune Diabetes.
Academic Article	Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials.
Academic Article	Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases.
Academic Article	Efficacy and safety of sipavibart for prevention of COVID-19 in individuals who are immunocompromised (SUPERNOVA): a randomised, controlled, double-blind, phase 3 trial.

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Immune
organoids