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One or more keywords matched the following properties of Bogdanov, Alexei
keywords fluorescence lifetime


Molecular imaging probes and relevance of our research. Microscopy of tissue samples has traditionally been one of the mainstays of experimental biology. However, advances in our understanding of the biochemical basis of disease has made it desirable and even necessary to be able to image these changes as they happen in vivo, using techniques which are noninvasive. The goal of such techniques are several fold:1) to obtain, analyze, and monitor disease related changes in molecular physiology over time and with high spatial resolution, i.e., up to the level of individual cells,2) to simultaneously acquire highly accurate anatomical images (tissue mapping) while mapping the functional status of tissues and organs, and3) to allow fundamental research findings to be translated into clinically diagnostic imaging strategies.Towards this end, ‘molecular imaging’ utilizes signals from endogenous or exogenous (chemically engeneered) substrates to probe chemical reactions in living cells. Such ‘reporters’ or ‘sensors’ have been successfully used to track real time changes in molecular physiology using modern diagnostic imaging methods such as magnetic resonance imaging (MRI), positron emission tomography (PET), gamma scintigraphy, optical fluorescence and near-infrared imaging, to relate these changes to the initiation and progression of diseases such as atherosclerosis and cancer. In order to gain wide-spread use in a clinical setting, molecular probes must be biocompatible, easily administered, specific and effective at low dosages.Our research addresses the issue of increasing selectivity and sensitivity of imaging probes. We also apply this research in realistic models of diseases.

One or more keywords matched the following items that are connected to Bogdanov, Alexei
Item TypeName
Academic Article Magnetically labeled cells can be detected by MR imaging.
Academic Article Uptake of dextran-coated monocrystalline iron oxides in tumor cells and macrophages.
Academic Article Antibody-mediated versus nontargeted delivery in a human small cell lung carcinoma model.
Academic Article Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model.
Academic Article Treatment of experimental brain tumors with trombospondin-1 derived peptides: an in vivo imaging study.
Academic Article Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging.
Academic Article Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate.
Academic Article Synthesis and testing of a binary catalytic system for imaging of signal amplification in vivo.
Academic Article Near-infrared fluorescent oligodeoxyribonucleotide reporters for sensing NF-kappaB DNA interactions in vitro.
Academic Article Hairpin-like fluorescent probe for imaging of NF-?B transcription factor activity.
Academic Article Sensing of transcription factor binding via cyanine dye pair fluorescence lifetime changes.
Academic Article Fluorescent macromolecular sensors of enzymatic activity for in vivo imaging.
Academic Article Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy.
Academic Article Imaging molecular expression on vascular endothelial cells by in vivo immunofluorescence microscopy.
Academic Article Fluorescence resonance energy transfer in near-infrared fluorescent oligonucleotide probes for detecting protein-DNA interactions.
Academic Article Plate capture assay of fluorescent oligonucleotide duplex reporter-transcription factor complexes.
Academic Article Orthotopic expression of noggin protein in cancer cells inhibits human lung carcinoma growth in vivo.
Academic Article In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium.
Academic Article The three-dimensional context of a double helix determines the fluorescence of the internucleoside-tethered pair of fluorophores.
Concept Microscopy, Fluorescence
Concept Spectrometry, Fluorescence
Concept Fluorescence
Concept Fluorescence Resonance Energy Transfer
Grant Molecular fluorescence lifetime sensor of pro-inflammatory signaling in diabetes
Academic Article Substrate-based near-infrared imaging sensors enable fluorescence lifetime contrast via built-in dynamic fluorescence quenching elements.
Academic Article Imaging NF-?B activity in a murine model of early stage diabetes.
Academic Article MR and fluorescence imaging of gadobutrol-induced optical clearing of red fluorescent protein signal in an in vivo cancer model.
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  • fluorescence
  • lifetime