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Search Results to Alexei A Bogdanov PhD

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One or more keywords matched the following properties of Bogdanov, Alexei

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http://www.umassmed.edu/radiology/research/laboratory-of-molecular-imaging-probes/about/

Molecular imaging probes and relevance of our research. Microscopy of tissue samples has traditionally been one of the mainstays of experimental biology. However, advances in our understanding of the biochemical basis of disease has made it desirable and even necessary to be able to image these changes as they happen in vivo, using techniques which are noninvasive. The goal of such techniques are several fold:1) to obtain, analyze, and monitor disease related changes in molecular physiology over time and with high spatial resolution, i.e., up to the level of individual cells,2) to simultaneously acquire highly accurate anatomical images (tissue mapping) while mapping the functional status of tissues and organs, and3) to allow fundamental research findings to be translated into clinically diagnostic imaging strategies.Towards this end, ‘molecular imaging’ utilizes signals from endogenous or exogenous (chemically engeneered) substrates to probe chemical reactions in living cells. Such ‘reporters’ or ‘sensors’ have been successfully used to track real time changes in molecular physiology using modern diagnostic imaging methods such as magnetic resonance imaging (MRI), positron emission tomography (PET), gamma scintigraphy, optical fluorescence and near-infrared imaging, to relate these changes to the initiation and progression of diseases such as atherosclerosis and cancer. In order to gain wide-spread use in a clinical setting, molecular probes must be biocompatible, easily administered, specific and effective at low dosages.Our research addresses the issue of increasing selectivity and sensitivity of imaging probes. We also apply this research in realistic models of diseases.


One or more keywords matched the following items that are connected to Bogdanov, Alexei

Item TypeName
Academic Article Improving MR quantification of regional blood volume with intravascular T1 contrast agents: accuracy, precision, and water exchange.
Academic Article Antibody-mediated versus nontargeted delivery in a human small cell lung carcinoma model.
Academic Article An adduct of cis-diamminedichloroplatinum(II) and poly(ethylene glycol)poly(L-lysine)-succinate: synthesis and cytotoxic properties.
Academic Article Novel gliosarcoma cell line expressing green fluorescent protein: A model for quantitative assessment of angiogenesis.
Academic Article Near-infrared optical imaging of protease activity for tumor detection.
Academic Article Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model.
Academic Article MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis.
Academic Article Treatment of experimental brain tumors with trombospondin-1 derived peptides: an in vivo imaging study.
Academic Article Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging.
Academic Article A long-circulating co-polymer in "passive targeting" to solid tumors.
Academic Article MR imaging and scintigraphy of gene expression through melanin induction.
Academic Article MR imaging of gene delivery to the central nervous system with an artificial vector.
Academic Article Continuous assessment of perfusion by tagging including volume and water extraction (CAPTIVE): a steady-state contrast agent technique for measuring blood flow, relative blood volume fraction, and the water extraction fraction.
Academic Article Non-invasive in vivo mapping of tumour vascular and interstitial volume fractions.
Academic Article Near-infrared fluorescent imaging of tumor apoptosis.
Academic Article Mechanism of gadophrin-2 accumulation in tumor necrosis.
Academic Article In vivo imaging of tumors with protease-activated near-infrared fluorescent probes.
Academic Article Measurement of tumor interstitial volume fraction: method and implication for drug delivery.
Academic Article In vivo assessment of vascular endothelial growth factor-induced angiogenesis.
Academic Article Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells.
Academic Article [Imaging of angiogenesis].
Academic Article A paramagnetic contrast agent for detecting tyrosinase activity.
Academic Article Environment-sensitive and enzyme-sensitive MR contrast agents.
Academic Article Carotid artery brain aneurysm model: in vivo molecular enzyme-specific MR imaging of active inflammation in a pilot study.
Academic Article Targeted signal-amplifying enzymes enhance MRI of EGFR expression in an orthotopic model of human glioma.
Academic Article Molecular magnetic resonance contrast agents for the detection of cancer: past and present.
Academic Article Hairpin-like fluorescent probe for imaging of NF-?B transcription factor activity.
Academic Article Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment.
Academic Article Imaging the pancreatic vasculature in diabetes models.
Academic Article Fluorescent macromolecular sensors of enzymatic activity for in vivo imaging.
Academic Article Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative study.
Academic Article Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets.
Academic Article Detection of early antiangiogenic effects in human colon adenocarcinoma xenografts: in vivo changes of tumor blood volume in response to experimental VEGFR tyrosine kinase inhibitor.
Academic Article Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model.
Academic Article Cell death in NF-kappaB-dependent tumour cell lines as a result of NF-kappaB trapping by linker-modified hairpin decoy oligonucleotide.
Academic Article In vivo quantification of transvascular water exchange during the acute phase of permanent stroke.
Academic Article Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques.
Academic Article Orthotopic expression of noggin protein in cancer cells inhibits human lung carcinoma growth in vivo.
Academic Article The three-dimensional context of a double helix determines the fluorescence of the internucleoside-tethered pair of fluorophores.
Academic Article Inflammation: imaging with methoxy poly(ethylene glycol)-poly-L-lysine-DTPA, a long-circulating graft copolymer.
Academic Article Experimental gastrointestinal hemorrhage: detection with contrast-enhanced MR imaging and scintigraphy.
Concept Disease Models, Animal
Concept Brain Neoplasms
Concept Lung Neoplasms
Concept Prostatic Neoplasms
Concept Models, Anatomic
Concept Neoplasms, Experimental
Concept Models, Biological
Concept Models, Statistical
Concept Mammary Neoplasms, Experimental
Concept Models, Structural
Concept Models, Chemical
Concept Models, Molecular
Concept Models, Theoretical
Concept Breast Neoplasms
Concept Neoplasms
Concept Skin Neoplasms
Concept Colonic Neoplasms
Academic Article Myeloperoxidase in human intracranial aneurysms: preliminary evidence.
Academic Article MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model.
Academic Article Aneurysm permeability following coil embolization: packing density and coil distribution.
Academic Article MR imaging of myeloperoxidase activity in a model of the inflamed aneurysm wall.
Academic Article Dual radiosensitization and anti-STAT3 anti-proliferative strategy based on delivery of gold nanoparticle - oligonucleotide nanoconstructs to head and neck cancer cells.
Academic Article Structure of the decoding center of the ribosome.
Academic Article Sensors for Proteolytic Activity Visualization and Their Application in Animal Models of Human Diseases.
Grant MR Signal Amplification for Receptor Imaging

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