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Regulation of the innate immune response and its impact on disease

Evelyn Kurt-JonesResearch in my laboratory is focused on the role of receptor-mediated events in the pathogenesis of infectious and inflammatory processes. The discovery of the Toll-like receptors (TLRs) and their importance in the regulation of host responses to infection has focused attention on the complex interplay between pathogen genes and these host innate immune proteins in determining the outcome of infection. Our studies have demonstrated that pathogen-TLR interactions contribute to early control of infection (macrophage activation, type I interferon), recruitment of immune effector cells (chemokines) and the development of a sustained adaptive immune response (T and B cell activation and maturation). We have focused on host- and pathogen-derived proteins that regulate the magnitude and duration of the innate inflammatory response during viral infection and the impact of these factors on disease severity. Recently we have examined the role of innate immunity in the wound healing and the recruitment of stem cells involved in the regeneration of mucosal tissues. These studies point to the key role of innate immune receptor-triggered pathways in the initiation of healing and repair of damaged tissues following microbial or chemical insults as well as their significant role in disease pathogenesis.

One or more keywords matched the following items that are connected to Kurt-Jones, Evelyn
Item TypeName
Academic Article Cutting edge: heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells.
Academic Article Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus.
Academic Article Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4.
Academic Article MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection.
Academic Article Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
Academic Article Toll-like receptor-mediated activation of neutrophils by influenza A virus.
Academic Article Respiratory syncytial virus activates innate immunity through Toll-like receptor 2.
Academic Article Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity.
Academic Article Pattern recognition receptors and the innate immune response to viral infection.
Academic Article Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
Academic Article Methods for in vivo and in vitro analysis of innate immune responses to Helicobacter pylori infection.
Academic Article Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation.
Academic Article Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
Academic Article Innate immunity to respiratory viruses.
Academic Article MDA5 and MAVS mediate type I interferon responses to coxsackie B virus.
Academic Article Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles.
Academic Article Role of specific innate immune responses in herpes simplex virus infection of the central nervous system.
Academic Article Innate immune responses to Helicobacter pylori infection: an overview.
Concept Immunity, Innate
Academic Article STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.
Academic Article Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2.
Academic Article Novel strategies for targeting innate immune responses to influenza.
Academic Article Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease.
Academic Article Expression of SARS coronavirus 1 spike protein from a herpesviral vector induces innate immune signaling and neutralizing antibody responses.
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  • Innate Immune Responses