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One or more keywords matched the following properties of Guertin, David


We study the biology of nutrient sensing. Sensing and adapting to changes in nutrient availability are basic survival requirements that occur in individual cells, by organs, and across whole organisms. Altered nutrient sensing is associated with cancer, diabetes, and infectious diseases and one of our long-term goals is to identify nodes of metabolic control that can be targeted therapeutically. We are specifically interested in the interplay between nutrient sensing signaling mechanisms and metabolism focusing on the mTOR pathway, and we have made many significant contributions towards understanding mTOR complex 2 (mTORC2) including its discovery, functions, and roles in health and disease. We also study adipose and liver organ biology including how these tissues utilize nutrients and communicate to maintain energy balance. In this area, we have made important advances in understanding the development and metabolism of brown adipose tissue, which was only recently recognized as a critical regulator of metabolic homeostasis in adult humans.


For more info, please vist our website at http://www.umassmed.edu/guertinlab/. 



One or more keywords matched the following items that are connected to Guertin, David
Item TypeName
Academic Article Adipocyte lineages: tracing back the origins of fat.
Academic Article Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Academic Article PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors.
Concept Adipose Tissue, White
Concept Adipose Tissue
Concept Adipose Tissue, Brown
Concept Body Fat Distribution
Academic Article Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed.
Academic Article Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.
Academic Article Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.
Academic Article Emerging Complexities in Adipocyte Origins and Identity.
Academic Article Amplification of Adipogenic Commitment by VSTM2A.
Academic Article Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue.
Academic Article Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.
Academic Article Brown Adipose Tissue Development and Metabolism.
Academic Article Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.
Academic Article Brown fat organogenesis and maintenance requires AKT1 and AKT2.
Academic Article mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis.
Academic Article The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development.
Academic Article In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate.
Academic Article Stable Isotope Tracing and Metabolomics to Study In Vivo Brown Adipose Tissue Metabolic Fluxes.
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  • Adipose Tissue