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Guertin, David
One or more keywords matched the following properties of
Guertin, David
Property
Value
keywords
mTOR Protein
One or more keywords matched the following items that are connected to
Guertin, David
Item Type
Name
Academic Article
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Academic Article
An expanding role for mTOR in cancer.
Academic Article
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
Academic Article
The pharmacology of mTOR inhibition.
Academic Article
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Academic Article
Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
Academic Article
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Academic Article
Functional genomics identifies TOR-regulated genes that control growth and division.
Academic Article
Defining the role of mTOR in cancer.
Academic Article
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.
Academic Article
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy.
Academic Article
Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.
Academic Article
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Academic Article
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.
Academic Article
mTOR-dependent cell survival mechanisms.
Academic Article
T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.
Academic Article
Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease.
Academic Article
Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.
Academic Article
Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.
Academic Article
Proteome and Phosphoproteome Analysis of Brown Adipocytes Reveals That RICTOR Loss Dampens Global Insulin/AKT Signaling.
Concept
Rapamycin-Insensitive Companion of mTOR Protein
Concept
TOR Serine-Threonine Kinases
Academic Article
Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.
Search Criteria
mTOR Protein