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One or more keywords matched the following properties of Guertin, David
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keywords mTOR Protein
One or more keywords matched the following items that are connected to Guertin, David
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Academic Article Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Academic Article An expanding role for mTOR in cancer.
Academic Article Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
Academic Article The pharmacology of mTOR inhibition.
Academic Article mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Academic Article Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
Academic Article Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Academic Article Functional genomics identifies TOR-regulated genes that control growth and division.
Academic Article Defining the role of mTOR in cancer.
Academic Article mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.
Academic Article Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy.
Academic Article Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.
Academic Article Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Academic Article mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.
Academic Article mTOR-dependent cell survival mechanisms.
Academic Article T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.
Academic Article Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease.
Academic Article Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.
Academic Article Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.
Academic Article Proteome and Phosphoproteome Analysis of Brown Adipocytes Reveals That RICTOR Loss Dampens Global Insulin/AKT Signaling.
Concept Rapamycin-Insensitive Companion of mTOR Protein
Concept TOR Serine-Threonine Kinases
Academic Article Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.
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  • mTOR Protein