I am an Associate Professor of Family Medicine and Community Health at UMass Chan School of Medicine, with joint appointments in the Division of Health Systems Science, Department of Medicine, and Department of Population and Quantitative Health Sciences. 

I am a Diplomate of the ABIM  and a Fellow of the American College of Physicians. I received my medical degree from the Patna Medical College, India. I completed an internal medicine residency at Unity Health System, Rochester, NY.  I obtained an MPH from the Johns Hopkins Bloomberg School of Public Health and completed research training at the Johns Hopkins Hospital as a Faculty Research Scholar supported by the NIH. I have taught and held faculty appointments at Johns Hopkins University and the Wake Forest University School of Medicine. I was the Associate Director for the Center for Drug Safety and Effectiveness and a core faculty member of the Evidence-Based Practice Center and the Center for Public Health and Human Rights at Johns Hopkins University.

My primary research focuses on evaluating the safety of medications. My areas of expertise include improving methods to conduct comparative effectiveness research, meta-analysis on harms, and developing methods to improve the quality of real-world evidence. I am interested in improving the care of older adults by evaluating the real-world safety and effectiveness of novel monoclonal agents for Alzheimer’s Disease and promoting deprescribing of inappropriate medications. My work has been supported by the NIH, FDA, AHRQ, PCORI, WHO-IARC, and the World Bank, and published in the NEJM, JAMA, BMJ, and the Lancet. These studies have been featured in Nature Medicine, the New York Times, CNN, the Washington Post, and the Wall Street Journal. I am a practicing general internist passionate about managing patients with complex medical conditions.

Representative Publications

Singh S, Li X, Cocoros NM, et al.  High-Risk Medications in Persons Living With Dementia: A Randomized Clinical Trial. JAMA Intern Med. 2024 Dec 1;184(12):1426-1433

Singh S, Beyrer J, Zhou X, et al. Development and Evaluation of the Algorithm CErtaInty Tool (ACE-IT) to Assess Electronic Medical Record and Claims-based Algorithms' Fit for Purpose for Safety Outcomes. Drug Saf. 2023 Jan;46(1):87-97

Singh S, Chang HY, Richards TM, et al. Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study. JAMA Intern Med. 2013 Apr 08; 173(7):534-9.

Singh S, Loke YK, Spangler JG, Furberg CD. Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis. CMAJ. 2011 Sep 06; 183(12):1359-66.

Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008 Sep 24; 300(12):1439-50

Singh S, Loke YK, Furberg CD. Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA. 2007 Sep 12; 298(10):1189-95