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One or more keywords matched the following properties of Wang, Dan
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keywords Gene Therapy
overview

Our research centers around gene therapy using adeno-associated virus (AAV) vectors. We carry out translational gene therapy studies targeting several neurological and metabolic diseases. In addition to targeting specific diseases, we develop therapeutic platforms based on molecular approaches such as genome editing and RNA-based methods. We also develop platform technologies to facilitate AAV-based gene therapy, such as animal modeling and AAV vector production.

In 2020, the lab starts accepting graduate students, postdoctoral researchers, and research associates. Send in your application and get in touch today!

Rotation Projects

- AAV gene therapy for genetic diseases

- Therapeutic genome editing

- RNA-based approaches to treating genetic diseases

- Interactions between AAV vector and host cell

- AAV vector capsid engineering

One or more keywords matched the following items that are connected to Wang, Dan
Item TypeName
Concept Genetic Therapy
Academic Article The potential of adeno-associated viral vectors for gene delivery to muscle tissue.
Academic Article State-of-the-art human gene therapy: part I. Gene delivery technologies.
Academic Article State-of-the-art human gene therapy: part II. Gene therapy strategies and clinical applications.
Academic Article Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.
Academic Article In Vivo Genome Editing Partially Restores Alpha1-Antitrypsin in a Murine Model of AAT Deficiency.
Academic Article Slow Infusion of Recombinant Adeno-Associated Viruses into the Mouse Cerebrospinal Fluid Space.
Academic Article Slow Intrathecal Injection of rAAVrh10 Enhances its Transduction of Spinal Cord and Therapeutic Efficacy in a Mutant SOD1 Model of ALS.
Academic Article AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer.
Academic Article Intrathecal Adeno-Associated Viral Vector-Mediated Gene Delivery for Adrenomyeloneuropathy.
Academic Article Adeno-associated virus vector as a platform for gene therapy delivery.
Academic Article Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity.
Academic Article CRISPR-Based Therapeutic Genome Editing: Strategies and In?Vivo Delivery by AAV Vectors.
Academic Article AAV-Mediated Gene Therapy for Glycosphingolipid Biosynthesis Deficiencies.
Academic Article Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo.
Academic Article AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice.
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  • Gene therapy