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One or more keywords matched the following properties of Lodato, Michael
keywords somatic mutation
keywords Neurodegenerative Disease
keywords Single-Cell Analysis
keywords Parkinson's Disease
keywords Alzheimer's Disease

Our laboratory focuses on the rates, causes, and consequences of somatic mutations in the human brain. The genome is under relentless attack by environmental and endogenous mutagens. This onslaught sometimes results in somatic mutation, which results in neighboring cells in an organ like the human brain having distinct genotypes, and raises the possibility that genetic information is lost in cells of the body as we age. Indeed, our work has shown that somatic mutations accumulate in post-mitotic human neurons during aging, sometimes affecting genes critical for neuronal function.

Somatic mutations are ultra-rare and cannot be studied using standard genomic analysis. Work in our lab involves applying cutting-edge single-cell genomic techniques pioneered by us and other groups to new questions in the field of somatic mutation, as well as innovating new technologies to allow us and the rest of the field to continue to study this process.

For more information about our lab, please visit our lab website.

Post Docs

Wet-lab and Bioinformatic postdoctoral fellow positions are available for candidates with recent Ph.D. or M.D./Ph.D. degrees in Molecular Biology, Neuroscience, Genetics, Genomics, Cell Biology, or related fields. They should be highly motivated, have a strong desire to learn, and excellent communication skills. Applicants should send their CV, summary of previous research and the name of three references to Dr. Michael Lodato.

Rotation Projects

Rotations will revolve around studying somatic mutations in the normal brain, in the diseased brain, and outside of the brain using single-cell genomics. Please contact Dr. Lodato for details.

One or more keywords matched the following items that are connected to Lodato, Michael
Item TypeName
Concept Sequence Analysis, DNA
Concept Software
Concept Oxidative Stress
Concept Polymorphism, Single Nucleotide
Concept Cockayne Syndrome
Concept Neurodegenerative Diseases
Concept Genetic Loci
Concept Nervous System Diseases
Concept Alzheimer Disease
Concept Genome, Human
Concept Embryonic Stem Cells
Concept Parkinson Disease
Academic Article Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.
Award or Honor Receipt Next Generation Leaders Council Appointment
Academic Article Aging and neurodegeneration are associated with increased mutations in single human neurons.
Academic Article Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms.
Academic Article Somatic mutation in single human neurons tracks developmental and transcriptional history.
Academic Article Functional integration of dopaminergic neurons directly converted from mouse fibroblasts.
Academic Article Linked-read analysis identifies mutations in single-cell DNA-sequencing data.
Academic Article Corrigendum: Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms.
Academic Article H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment.
Academic Article PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation.
Concept Whole Genome Sequencing
Concept Neural Stem Cells
Concept High-Throughput Nucleotide Sequencing
Academic Article Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction.
Academic Article Somatic genomic changes in single Alzheimer's disease neurons.
Academic Article Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity.
Academic Article Editorial: Somatic mutations, genome mosaicism and aging.
Academic Article Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements.
Academic Article Prevalence and mechanisms of somatic deletions in single human neurons during normal aging and in DNA repair disorders.
Academic Article Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortex.
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