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Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.

One or more keywords matched the following properties of Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.

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has minor subject area list	Animals; Biological Availability; Cell Line, Tumor; Chemistry Techniques, Synthetic; Dogs; Female; Half-Life; Humans; Male; Mice, Nude; Molecular Targeted Therapy; Mutation; Proto-Oncogene Proteins c-raf; Rats, Sprague-Dawley; Structure-Activity Relationship; Xenograft Model Antitumor Assays

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Organic Synthesis