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Nundel, Kerstin
One or more keywords matched the following properties of Nundel, Kerstin
PropertyValue
keywords autoimmunity, SLE, B cell development, TAM receptors
overview

Dr. Nündel’s research interest is in understanding how the balance between self – non-self recognition is achieved in the immune system. Currently she is investigating the role of nucleic acid sensing TLRs in B cell tolerance, survival, differentiation and migration. Her in vitro studies on autoreactive B cells are accompanied by studying the mechanisms of B cell activation and migration by self-antigens in mouse models of Systemic Lupus Erythematosus (SLE). Dr. Nündel’s work on B cell migration in SLE is currently funded by a grant from the Lupus Research Alliance, in which she is testing already approved cancer treatments to decrease end-organ damage by inhibiting B cell migration.
One or more keywords matched the following items that are connected to Nundel, Kerstin
Item TypeName
Academic Article RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes.
Academic Article Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop.
Concept DNA-Binding Proteins
Concept Interferon-beta
Concept Bone Resorption
Concept Cell Lineage
Concept Humans
Concept Mice, Inbred CBA
Concept Bone and Bones
Concept Receptor, Interferon alpha-beta
Concept Mice, Inbred BALB C
Concept B-Lymphocyte Subsets
Concept Cell Survival
Concept Toll-Like Receptors
Concept Gene Rearrangement, B-Lymphocyte, Heavy Chain
Concept Animals
Concept Lymphoma, B-Cell
Concept Dendritic Cells
Concept Mice, Knockout
Concept Breeding
Concept Mice
Concept Cell Differentiation
Concept Bone Marrow Cells
Concept T-Box Domain Proteins
Concept Adult
Concept Plasma Cells
Concept Mice, Inbred C57BL
Concept Cells, Cultured
Concept Mice, Transgenic
Concept Cell Proliferation
Concept beta Catenin
Concept Hematopoietic Stem Cells
Concept Bone Marrow
Concept B-Cell Activating Factor
Concept Th1 Cells
Concept Mice, SCID
Concept Autoimmunity
Concept Infant, Newborn
Concept Stromal Cells
Concept Cell Line
Concept B-Lymphocytes
Concept Influenza A virus
Concept Receptors, Antigen, B-Cell
Concept Gene Rearrangement, B-Lymphocyte, Light Chain
Concept Myeloid Cells
Concept Radiation Chimera
Concept Cell Count
Academic Article The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells.
Academic Article Suppression of systemic autoimmunity by the innate immune adaptor STING.
Academic Article An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual.
Academic Article Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.
Academic Article TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus.
Academic Article Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?
Grant TLR9 regulates Axl dependent migration of autoreactive B cells
Academic Article Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence.
Academic Article Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM.
Academic Article The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination.
Academic Article Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody.
Academic Article A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens.
Academic Article Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses.
Academic Article Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands.
Academic Article Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.
Academic Article Human peripheral CD2-/lo T cells: an extrathymic population of early differentiated, developing T cells.
Academic Article Role of type I interferons in the activation of autoreactive B cells.
Academic Article Beyond transitional selection: New roles for BLyS in peripheral tolerance.
Academic Article Role of Interferon-?-Producing Th1 Cells in a Murine Model of Type I Interferon-Independent Autoinflammation Resulting From DNase II Deficiency.
Academic Article Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 V?8 B Cells.
Academic Article The role of nucleic acid sensors and type I IFNs in patient populations and animal models of autoinflammation.
Academic Article Monoallelic IRF5 deficiency in B cells prevents murine lupus.
Academic Article Human nasal wash RNA-Seq reveals distinct cell-specific innate immune responses in influenza versus SARS-CoV-2.
Concept G1 Phase Cell Cycle Checkpoints
Academic Article Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis.
Academic Article Glucose Requirement of Antigen-Specific Autoreactive B Cells and CD4+ T Cells.
Academic Article TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance.
Academic Article Activation of Autoreactive Lymphocytes in the Lung by STING Gain-of-function Mutation Radioresistant Cells.
Search Criteria
  • autoimmunity
  • SLE
  • B
  • cell
  • development
  • TAM
  • receptors