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Search Results to Lisa Ann Cavacini PhD

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My laboratory focuses on humoral immunity, and human monoclonal antibodies (HMab) in particular, for infectious disease, cancer and autoimmune disease. A large number of HMab have been developed to study the structure/function of the HIV envelope protein with the immune system to inform active immunization strategies. HMab have also been used for passive immunotherapy in monkey models and clinical trials in humans, including the first trial of a human anti-HIV antibody.  Through the study of antibody diversity and engineering of HMab, we have demonstrated the preventative potential of anti-HIV IgA.  Antibody molecules are also being developed that can redirect immune cells to destroy HIV (bispecific antibodies).  HMab to a number of infectious disease targets, including bacteria and virus are being developed to follow the successful transfer of HMab to Pseudomonas aeruginosa and Staphylococcus aureus for clinical development.  Antibody molecules are also being designed to target siRNA to squamous cell carcinoma for treatment of head and neck cancer.  We have also begun to develop antibody molecules for vectored delivery.  Finally, we are developing protocols that result in affinity matured HMab in immunized humanized mice.  This model allows development of HMab to targets for which an in vivo response is either not possible or safe.  The laboratory has established itself as an important resource laboratory in the area of human monoclonal antibodies.  Not only has the research furthered our understanding of disease pathogenesis, but also has generated reagents used throughout the world. 

One or more keywords matched the following items that are connected to Cavacini, Lisa

Item TypeName
Concept Immunization, Passive
Academic Article Post-exposure prophylaxis with human monoclonal antibodies prevented SHIV89.6P infection or disease in neonatal macaques.
Academic Article Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques.
Academic Article Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody.
Academic Article Dichotomy in cross-clade reactivity and neutralization by HIV-1 sera: Implications for active and passive immunotherapy.
Academic Article Postnatal pre- and postexposure passive immunization strategies: protection of neonatal macaques against oral simian-human immunodeficiency virus challenge.
Academic Article Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge.
Academic Article Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission?
Academic Article Protection of neonatal macaques against experimental SHIV infection by human neutralizing monoclonal antibodies.
Academic Article T-cell immunity in murine malaria: adoptive transfer of resistance to Plasmodium chabaudi adami in nude mice with splenic T cells.
Academic Article Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.
Academic Article Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration.

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