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CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion.
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.
Understanding and repurposing CRISPR-mediated alternative splicing.
A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In?Vivo Genome Editing.
Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins.
Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope.
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice.
Deletion and replacement of long genomic sequences using prime editing.
AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway.
Genome-wide detection of CRISPR editing in vivo using GUIDE-tag.
A split prime editor with untethered reverse transcriptase and circular RNA template.