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Thompson, Paul

One or more keywords matched the following items that are connected to Thompson, Paul

Item Type	Name
Concept	Membrane Proteins
Concept	Protein Binding
Concept	Protein Transport
Concept	DNA-Binding Proteins
Concept	Protein Processing, Post-Translational
Concept	HMGA Proteins
Concept	Phosphate-Binding Proteins
Concept	Tumor Suppressor Protein p53
Concept	Protein Tyrosine Phosphatase, Non-Receptor Type 22
Concept	Intermediate Filament Proteins
Concept	Chromosomal Proteins, Non-Histone
Concept	Cell Cycle Proteins
Concept	Protein Interaction Mapping
Concept	Receptors, G-Protein-Coupled
Concept	Nuclear Proteins
Concept	Recombinant Proteins
Concept	Protein Kinases
Concept	Protein Interaction Domains and Motifs
Concept	S100 Proteins
Concept	Extracellular Matrix Proteins
Concept	Intracellular Signaling Peptides and Proteins
Concept	ets-Domain Protein Elk-1
Concept	Viral Proteins
Concept	Repressor Proteins
Concept	Protein-Arginine N-Methyltransferases
Concept	Myelin Proteins
Concept	Proteins
Concept	Cytoskeletal Proteins
Concept	Protein Structure, Tertiary
Concept	Adaptor Proteins, Signal Transducing
Concept	Oncogene Protein v-akt
Concept	Green Fluorescent Proteins
Concept	Bacterial Proteins
Concept	Calcium-Binding Proteins
Concept	Viral Nonstructural Proteins
Concept	Neoplasm Proteins
Concept	Caenorhabditis elegans Proteins
Concept	Microfilament Proteins
Concept	Proto-Oncogene Proteins c-fos
Concept	Protein Isoforms
Concept	Protein Conformation
Concept	Apoptosis Regulatory Proteins
Concept	cdc42 GTP-Binding Protein
Concept	Insulin-Like Growth Factor Binding Protein 1
Concept	Armadillo Domain Proteins
Concept	Milk Proteins
Concept	RNA-Binding Proteins
Concept	Protein Array Analysis
Concept	CARD Signaling Adaptor Proteins
Academic Article	Kinetic mechanism of protein arginine methyltransferase 1.
Academic Article	Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1.
Academic Article	Chemical and biological methods to detect post-translational modifications of arginine.
Academic Article	Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5.
Academic Article	Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis.
Academic Article	Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism.
Academic Article	Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.
Academic Article	A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1.
Academic Article	Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion.
Academic Article	Mechanistic studies of agmatine deiminase from multiple bacterial species.
Academic Article	Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor a target gene activation.
Academic Article	Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4.
Academic Article	Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis.
Academic Article	Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination.
Academic Article	Identification of PADI2 as a potential breast cancer biomarker and therapeutic target.
Academic Article	Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors.
Academic Article	The protein arginine deiminases: Structure, function, inhibition, and disease.
Academic Article	Inhibiting protein arginine deiminases has antioxidant consequences.
Academic Article	Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.
Academic Article	The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.
Academic Article	Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe.
Academic Article	Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock?
Academic Article	N-a-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.
Academic Article	Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors.
Academic Article	Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis.
Academic Article	Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.
Academic Article	Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity.
Academic Article	Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability.
Academic Article	Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.
Academic Article	Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells.
Academic Article	Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
Academic Article	Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential.
Academic Article	Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity.
Academic Article	Activity-based protein profiling of protein arginine methyltransferase 1.
Academic Article	The development of N-a-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-a-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.
Academic Article	A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation.
Academic Article	Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation.
Academic Article	Characterization and inactivation of an agmatine deiminase from Helicobacter pylori.
Academic Article	Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.
Academic Article	Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation.
Academic Article	Using unnatural amino acid mutagenesis to probe the regulation of PRMT1.
Academic Article	Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.
Academic Article	Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Academic Article	Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation.
Academic Article	A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.
Academic Article	Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6).
Academic Article	Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway.
Academic Article	A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation.
Academic Article	Pluripotency: citrullination unravels stem cells.
Academic Article	Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors.
Academic Article	Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates.
Academic Article	Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates.
Academic Article	In situ generation of a bisubstrate analogue for protein arginine methyltransferase 1.
Academic Article	Protein arginine deiminase 4: a target for an epigenetic cancer therapy.
Academic Article	A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming.
Academic Article	A fluopol-ABPP HTS assay to identify PAD inhibitors.
Academic Article	Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo.
Academic Article	Potential role for PADI-mediated histone citrullination in preimplantation development.
Academic Article	Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Academic Article	Chemical biology of protein arginine modifications in epigenetic regulation.
Academic Article	Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells.
Academic Article	Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation.
Academic Article	Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.
Academic Article	Chemical Proteomic Platform To Identify Citrullinated Proteins.
Academic Article	Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer.
Academic Article	Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis.
Academic Article	Detection and identification of protein citrullination in complex biological systems.
Academic Article	Protein Arginine Methylation and Citrullination in Epigenetic Regulation.
Academic Article	Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.
Academic Article	Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.
Academic Article	Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland.
Academic Article	Regulation of p53 target gene expression by peptidylarginine deiminase 4.
Academic Article	Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation.
Academic Article	GnRH Stimulates Peptidylarginine Deiminase Catalyzed Histone Citrullination in Gonadotrope Cells.
Academic Article	D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy.
Academic Article	An improved synthesis of haloaceteamidine-based inactivators of protein arginine deiminase 4 (PAD4).
Academic Article	Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation.
Academic Article	Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.
Academic Article	Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
Academic Article	Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Academic Article	Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription.
Academic Article	Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration.
Academic Article	Citrullination regulates the expression of insulin-like growth factor-binding protein 1 (IGFBP1) in ovine uterine luminal epithelial cells.
Academic Article	Citrullination Inactivates Nicotinamide- N-methyltransferase.
Academic Article	Development of Activity-Based Proteomic Probes for Protein Citrullination.
Academic Article	The Development of Benzimidazole-Based Clickable Probes for the Efficient Labeling of Cellular Protein Arginine Deiminases (PADs).
Academic Article	A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.
Academic Article	Photochemical Control of Protein Arginine Deiminase (PAD) Activity.
Academic Article	The Rheumatoid Arthritis-Associated Citrullinome.
Academic Article	BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway.
Academic Article	Histone Citrullination Represses MicroRNA Expression, Resulting in Increased Oncogene mRNAs in Somatolactotrope Cells.
Academic Article	Nicotine induces neutrophil extracellular traps.
Academic Article	Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation.
Academic Article	A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22.
Academic Article	PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling.
Academic Article	Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown.
Academic Article	Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus.
Academic Article	Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination.
Academic Article	Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in?Reconstructed Human Epidermis.
Academic Article	Peptidyl arginine deiminases: detection and functional analysis of protein citrullination.
Academic Article	Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination.
Academic Article	Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N-Methyltransferase.
Academic Article	Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2.
Academic Article	Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1? Maturation and ASC Speck Formation in Macrophages.
Academic Article	Halogen Bonding Increases the Potency and Isozyme Selectivity of Protein Arginine Deiminase 1 Inhibitors.
Academic Article	Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury.
Academic Article	Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells.
Academic Article	Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination.
Academic Article	Emergence of SARM1 as a Potential Therapeutic Target for Wallerian-type Diseases.
Academic Article	Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1.
Academic Article	Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines.
Academic Article	Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock.
Academic Article	Identification and Characterization of the Lactating Mouse Mammary Gland Citrullinome.
Academic Article	Succination inactivates gasdermin D and blocks pyroptosis.
Academic Article	Identification of the first noncompetitive SARM1 inhibitors.
Academic Article	Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis.
Academic Article	Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice.
Academic Article	Site-specific incorporation of citrulline into proteins in mammalian cells.
Academic Article	Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188.
Academic Article	Chemical biology of protein citrullination by the protein A arginine deiminases.
Academic Article	Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design.
Academic Article	Progesterone stimulates histone citrullination to increase IGFBP1 expression in uterine cells.
Academic Article	Donated chemical probes for open science.
Academic Article	Human cytomegalovirus-induced host protein citrullination is crucial for viral replication.
Academic Article	A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration.
Academic Article	PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis.
Academic Article	A Streamlined Data Analysis Pipeline for the Identification of Sites of Citrullination.
Academic Article	Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.
Academic Article	Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4.
Academic Article	Proximity-Dependent Labeling of Cysteines.
Concept	NLR Family, Pyrin Domain-Containing 3 Protein
Concept	N-Myc Proto-Oncogene Protein
Concept	Protein Domains
Concept	Anti-Citrullinated Protein Antibodies
Concept	Protein-Arginine Deiminases
Concept	Ataxia Telangiectasia Mutated Proteins
Concept	Myxovirus Resistance Proteins
Concept	Protein Aggregates
Academic Article	Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition.
Academic Article	The chemical biology of NAD+ regulation in axon degeneration.
Academic Article	Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2.
Academic Article	Carbamylation of Integrin aIIb?3: The Mechanistic Link to Platelet Dysfunction in ESKD.
Academic Article	Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models.
Academic Article	Current insights into the role of citrullination in thrombosis.
Academic Article	Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells.
Academic Article	Targeting STING oligomerization with small-molecule inhibitors.
Academic Article	A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels.
Academic Article	Protein citrullination: inhibition, identification and insertion.
Academic Article	Citrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors.
Academic Article	NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils.
Academic Article	Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA.
Academic Article	PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS.
Academic Article	Muscle-specific pyruvate kinase isoforms, PKM1 and PKM2, regulate mammalian SWI/SNF proteins and histone 3 phosphorylation during myoblast differentiation.
Academic Article	Muscle-Specific Pyruvate Kinase Isoforms, Pkm1 and Pkm2, Regulate Mammalian SWI/SNF Proteins and Histone 3 Phosphorylation During Myoblast Differentiation.
Academic Article	AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment-Efficacy and Mechanism.
Academic Article	Protein Citrullination in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases.

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GTP Binding Proteins