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Thompson, Paul
One or more keywords matched the following items that are connected to Thompson, Paul
Item TypeName
Concept Hydrolases
Concept Peptide Hydrolases
Academic Article Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.
Academic Article Mechanistic studies of agmatine deiminase from multiple bacterial species.
Academic Article Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor a target gene activation.
Academic Article Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4.
Academic Article Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination.
Academic Article Identification of PADI2 as a potential breast cancer biomarker and therapeutic target.
Academic Article Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors.
Academic Article Inhibiting protein arginine deiminases has antioxidant consequences.
Academic Article Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.
Academic Article The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.
Academic Article Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe.
Academic Article Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock?
Academic Article N-a-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.
Academic Article Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis.
Academic Article Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.
Academic Article Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity.
Academic Article Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability.
Academic Article Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.
Academic Article Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells.
Academic Article Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
Academic Article Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential.
Academic Article The development of N-a-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-a-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.
Academic Article A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation.
Academic Article Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation.
Academic Article Characterization and inactivation of an agmatine deiminase from Helicobacter pylori.
Academic Article Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.
Academic Article Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.
Academic Article Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Academic Article Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation.
Academic Article A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.
Academic Article Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway.
Academic Article Pluripotency: citrullination unravels stem cells.
Academic Article Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates.
Academic Article Protein arginine deiminase 4: a target for an epigenetic cancer therapy.
Academic Article A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming.
Academic Article A fluopol-ABPP HTS assay to identify PAD inhibitors.
Academic Article Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo.
Academic Article Potential role for PADI-mediated histone citrullination in preimplantation development.
Academic Article Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Academic Article Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells.
Academic Article Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation.
Academic Article Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.
Academic Article Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer.
Academic Article Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis.
Academic Article Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.
Academic Article Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland.
Academic Article Regulation of p53 target gene expression by peptidylarginine deiminase 4.
Academic Article Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation.
Academic Article Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.
Academic Article Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
Academic Article Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Academic Article Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription.
Academic Article Photochemical Control of Protein Arginine Deiminase (PAD) Activity.
Academic Article Nicotine induces neutrophil extracellular traps.
Academic Article Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation.
Academic Article PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling.
Academic Article Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown.
Academic Article Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus.
Academic Article Identification of the first noncompetitive SARM1 inhibitors.
Academic Article The role of SERPIN citrullination in thrombosis.
Academic Article Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2.
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  • Hydrolases