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Thompson, Paul
One or more keywords matched the following items that are connected to Thompson, Paul
Item TypeName
Academic Article Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism.
Academic Article Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.
Academic Article Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor a target gene activation.
Academic Article Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4.
Academic Article Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis.
Academic Article Identification of PADI2 as a potential breast cancer biomarker and therapeutic target.
Academic Article Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors.
Academic Article The protein arginine deiminases: Structure, function, inhibition, and disease.
Academic Article Inhibiting protein arginine deiminases has antioxidant consequences.
Academic Article Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.
Academic Article The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.
Academic Article Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe.
Academic Article Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock?
Academic Article N-a-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.
Academic Article Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis.
Academic Article Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.
Academic Article Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity.
Academic Article Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability.
Academic Article Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.
Academic Article Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells.
Academic Article Protein arginine deiminase 4: evidence for a reverse protonation mechanism.
Academic Article Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential.
Academic Article The development of N-a-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-a-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.
Academic Article A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation.
Academic Article Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation.
Academic Article Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.
Academic Article Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.
Academic Article Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Academic Article Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation.
Academic Article A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.
Academic Article Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway.
Academic Article Pluripotency: citrullination unravels stem cells.
Academic Article Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates.
Academic Article Protein arginine deiminase 4: a target for an epigenetic cancer therapy.
Academic Article A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming.
Academic Article A fluopol-ABPP HTS assay to identify PAD inhibitors.
Academic Article Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo.
Academic Article Potential role for PADI-mediated histone citrullination in preimplantation development.
Academic Article Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Academic Article Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells.
Academic Article A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy.
Academic Article Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation.
Academic Article Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.
Academic Article Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer.
Academic Article Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis.
Academic Article Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.
Academic Article Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.
Academic Article Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland.
Academic Article Regulation of p53 target gene expression by peptidylarginine deiminase 4.
Academic Article Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation.
Academic Article GnRH Stimulates Peptidylarginine Deiminase Catalyzed Histone Citrullination in Gonadotrope Cells.
Academic Article D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy.
Academic Article An improved synthesis of haloaceteamidine-based inactivators of protein arginine deiminase 4 (PAD4).
Academic Article Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.
Academic Article Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
Academic Article Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Academic Article Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription.
Academic Article Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration.
Academic Article Citrullination regulates the expression of insulin-like growth factor-binding protein 1 (IGFBP1) in ovine uterine luminal epithelial cells.
Academic Article Development of Activity-Based Proteomic Probes for Protein Citrullination.
Academic Article The Development of Benzimidazole-Based Clickable Probes for the Efficient Labeling of Cellular Protein Arginine Deiminases (PADs).
Academic Article A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.
Academic Article Photochemical Control of Protein Arginine Deiminase (PAD) Activity.
Academic Article BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway.
Academic Article Histone Citrullination Represses MicroRNA Expression, Resulting in Increased Oncogene mRNAs in Somatolactotrope Cells.
Academic Article Nicotine induces neutrophil extracellular traps.
Academic Article Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation.
Academic Article A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22.
Academic Article PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling.
Academic Article Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown.
Academic Article Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus.
Academic Article Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination.
Academic Article Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in?Reconstructed Human Epidermis.
Academic Article Peptidyl arginine deiminases: detection and functional analysis of protein citrullination.
Academic Article Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination.
Academic Article Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2.
Academic Article Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1? Maturation and ASC Speck Formation in Macrophages.
Academic Article Halogen Bonding Increases the Potency and Isozyme Selectivity of Protein Arginine Deiminase 1 Inhibitors.
Academic Article Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury.
Academic Article Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells.
Academic Article Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination.
Academic Article Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines.
Academic Article Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock.
Academic Article Identification and Characterization of the Lactating Mouse Mammary Gland Citrullinome.
Academic Article Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis.
Academic Article Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice.
Academic Article Site-specific incorporation of citrulline into proteins in mammalian cells.
Academic Article Chemical biology of protein citrullination by the protein A arginine deiminases.
Academic Article Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design.
Academic Article Human cytomegalovirus-induced host protein citrullination is crucial for viral replication.
Academic Article PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis.
Academic Article A Streamlined Data Analysis Pipeline for the Identification of Sites of Citrullination.
Academic Article Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4.
Academic Article Proximity-Dependent Labeling of Cysteines.
Concept Protein-Arginine Deiminases
Academic Article Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells.
Academic Article Protein citrullination: inhibition, identification and insertion.
Academic Article NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils.
Academic Article Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA.
Academic Article PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS.
Academic Article AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment-Efficacy and Mechanism.
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  • Protein Arginine Deiminases