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Mello, Craig

One or more keywords matched the following properties of Mello, Craig

Property	Value
overview	Academic Background Blais University Chair in Molecular Medicine Dr. Craig C. Mello received his B.Sc. degree in Biochemistry from Brown University in 1982, and received his Ph.D. from Harvard University in 1990. From 1990 to 1994 he conducted postdoctoral research at the Fred Hutchinson Cancer Research Center in Seattle, WA. He has been a member of the University of Massachusetts Medical School faculty since 1995, and a Howard Hughes Medical Investigator since 2000. His pioneering research on RNAi, in collaboration with Dr. Andrew Fire, has been recognized with numerous awards culminating with the prestigious 2006 Nobel Prize in Physiology or Medicine. RNA-mediated Gene Regulation In much the same way that we use short search queries to navigate the World Wide Web, cells use short segments of genetic code to find and regulate matching information. The proteins that mediate these searches are highly conserved in plants and animals and are essential for viability and fertility. Craig Mello is investigating how these search mechanisms work and how organisms use them to regulate, share, and propagate genetic information. For more information about Dr. Mello's research, please visit his Howard Hughes Medical Institute page at: https://www.hhmi.org/research/rna-interference-and-development-c-elegans

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Value

overview

Academic Background

Blais University Chair in Molecular Medicine

Dr. Craig C. Mello received his B.Sc. degree in Biochemistry from Brown University in 1982, and received his Ph.D. from Harvard University in 1990. From 1990 to 1994 he conducted postdoctoral research at the Fred Hutchinson Cancer Research Center in Seattle, WA. He has been a member of the University of Massachusetts Medical School faculty since 1995, and a Howard Hughes Medical Investigator since 2000. His pioneering research on RNAi, in collaboration with Dr. Andrew Fire, has been recognized with numerous awards culminating with the prestigious 2006 Nobel Prize in Physiology or Medicine.

RNA-mediated Gene Regulation

In much the same way that we use short search queries to navigate the World Wide Web, cells use short segments of genetic code to find and regulate matching information. The proteins that mediate these searches are highly conserved in plants and animals and are essential for viability and fertility. Craig Mello is investigating how these search mechanisms work and how organisms use them to regulate, share, and propagate genetic information.

For more information about Dr. Mello's research, please visit his Howard Hughes Medical Institute page at:

https://www.hhmi.org/research/rna-interference-and-development-c-elegans

One or more keywords matched the following items that are connected to Mello, Craig

Item Type	Name
Academic Article	Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos.
Academic Article	RNAi in C. elegans: soaking in the genome sequence.
Academic Article	MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans.
Academic Article	The rde-1 gene, RNA interference, and transposon silencing in C. elegans.
Academic Article	Genetic requirements for inheritance of RNAi in C. elegans.
Academic Article	Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.
Academic Article	Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead.
Academic Article	Sequence-specific inhibition of small RNA function.
Academic Article	The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins.
Academic Article	A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans.
Academic Article	Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.
Academic Article	Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Academic Article	Return to the RNAi world: rethinking gene expression and evolution (Nobel Lecture).
Academic Article	RNA interference in Caenorhabditis elegans.
Academic Article	Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.
Academic Article	PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans.
Academic Article	Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.
Academic Article	The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation.
Academic Article	Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway.
Academic Article	Primal RNAs: The end of the beginning?
Academic Article	The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans.
Academic Article	MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression.
Academic Article	RNAi (Nematodes: Caenorhabditis elegans).
Academic Article	Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi.
Academic Article	The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans.
Academic Article	The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos.
Academic Article	Revealing the world of RNA interference.
Academic Article	The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis.
Academic Article	Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.
Academic Article	Return to the RNAi world: rethinking gene expression and evolution.
Academic Article	NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division.
Academic Article	Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans.
Academic Article	C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts.
Academic Article	piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline.
Academic Article	Specific miRNA stabilization by Gld2-catalyzed monoadenylation.
Academic Article	CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors.
Concept	Genomic Instability
Concept	Gene Expression Profiling
Concept	Spermatocytes
Concept	Genes, Lethal
Concept	Fibroblasts
Concept	RNA
Concept	RNA, Helminth
Concept	Temperature
Concept	Sequence Analysis, DNA
Concept	Spermatogenesis
Concept	Endocytosis
Concept	RNA, Small Interfering
Concept	Base Pairing
Concept	Cell Lineage
Concept	Humans
Concept	Sequence Analysis, RNA
Concept	Multigene Family
Concept	Mitogen-Activated Protein Kinases
Concept	Heterozygote
Concept	DNA Topoisomerases, Type II
Concept	Cell Division
Concept	Sperm Maturation
Concept	Cyclin-Dependent Kinases
Concept	Drosophila melanogaster
Concept	COS Cells
Concept	DNA Helicases
Concept	RNA Interference
Concept	RNA Caps
Concept	Ribonuclease III
Concept	Sex Determination Analysis
Concept	Infectious Disease Transmission, Vertical
Concept	Genome, Helminth
Concept	Genomics
Concept	Cricetinae
Concept	Administration, Oral
Concept	Cyclins
Concept	Soy Foods
Concept	Transcription Initiation Site
Concept	Genetic Testing
Concept	Retroelements
Concept	Molecular Biology
Concept	Genomic Imprinting
Concept	Open Reading Frames
Concept	Exoribonucleases
Concept	Binding, Competitive
Concept	Blotting, Northern
Concept	Dosage Compensation, Genetic
Concept	RNA-Induced Silencing Complex
Concept	CDC2 Protein Kinase
Concept	Suppression, Genetic
Concept	Antibodies
Concept	Ovum
Concept	Germ Cells
Concept	Chromosomes, Artificial, Yeast
Concept	Blotting, Western
Concept	RNA, Untranslated
Concept	Genes, Helminth
Concept	Endoribonucleases
Concept	Endotoxins
Concept	Genome
Concept	Homozygote
Concept	Spermatozoa
Concept	Genetic Techniques
Concept	Mice
Concept	Endopeptidases
Concept	Nucleosomes
Concept	Microscopy, Confocal
Concept	Gene Expression Regulation, Developmental
Concept	RNA Helicases
Concept	Hot Temperature
Concept	Transgenes
Concept	Phosphatidylinositol Phosphates
Concept	Morphogenesis
Concept	5' Flanking Region
Concept	Mutagenesis, Insertional
Concept	Mice, Inbred C57BL
Concept	Regulatory Sequences, Nucleic Acid
Concept	Gene Expression Regulation
Concept	Endoderm
Concept	Enzyme Activation
Concept	Mutation
Concept	RNA Stability
Concept	Zebrafish Proteins
Concept	Phosphoric Monoester Hydrolases
Concept	Drosophila
Concept	Bacillus thuringiensis
Concept	Nucleic Acid Denaturation
Concept	RNA, Messenger
Concept	Cell Proliferation
Concept	Membrane Glycoproteins
Concept	RNA, Transfer, Gly
Concept	DNA, Viral
Concept	Sex Chromosomes
Concept	Adaptor Proteins, Signal Transducing
Concept	RNA Processing, Post-Transcriptional
Concept	Genetic Engineering
Concept	DEAD-box RNA Helicases
Concept	Epididymis
Concept	Microscopy, Fluorescence
Concept	Genes, Reporter
Concept	Glycogen Synthase Kinase 3
Concept	Vacuolar Proton-Translocating ATPases
Concept	Epigenesis, Genetic
Concept	Reverse Transcriptase Polymerase Chain Reaction
Concept	Recombinant Fusion Proteins
Concept	Models, Genetic
Concept	Endosomes
Concept	RNA Polymerase II
Concept	Retinoblastoma
Concept	Sequence Alignment
Concept	Disorders of Sex Development
Concept	Gene Library
Concept	Crosses, Genetic
Concept	Reproducibility of Results
Concept	Embryonic Induction
Concept	Peptide Mapping
Concept	Codon, Nonsense
Concept	Oocytes
Concept	Genome-Wide Association Study
Concept	rac GTP-Binding Proteins
Concept	Proteomics
Concept	Embryo, Nonmammalian
Concept	RNA Splicing
Concept	Gene Components
Concept	Transfection
Concept	Deoxyribonucleases
Concept	Schizosaccharomyces
Concept	Body Patterning
Concept	Microinjections
Concept	Heterochromatin
Concept	Polymerase Chain Reaction
Concept	Proteasome Endopeptidase Complex
Concept	Gene Deletion
Concept	Genetic Vectors
Concept	Vulva
Concept	Testis
Concept	MicroRNAs
Concept	Promoter Regions, Genetic
Concept	Gene Silencing
Concept	Gene Duplication
Concept	Base Sequence
Concept	Alleles
Concept	Plasmids
Concept	Cloning, Molecular
Concept	Chromatin Assembly and Disassembly
Concept	Immunohistochemistry
Concept	RNA, Antisense
Concept	DNA, Single-Stranded
Concept	Larva
Concept	Gene Transfer Techniques
Concept	DNA Transposable Elements
Concept	RNA-Binding Proteins
Concept	RNA, Double-Stranded
Concept	Cosmids
Academic Article	Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans.
Academic Article	The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression.
Academic Article	A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection.
Academic Article	RNA Interference in Caenorhabditis elegans.
Academic Article	A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi.
Academic Article	Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF.
Academic Article	Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals.
Academic Article	The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans.
Academic Article	The PIE-1 protein and germline specification in C. elegans embryos.
Academic Article	Repression of gene expression in the embryonic germ lineage of C. elegans.
Academic Article	The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans.
Academic Article	SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos.
Academic Article	The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C.?elegans.
Academic Article	A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C.?elegans.
Academic Article	Robust Genome Editing with Short Single-Stranded and Long, Partially Single-Stranded DNA Donors in Caenorhabditis elegans.
Academic Article	Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C.?elegans Germline.
Academic Article	ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals.
Academic Article	GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability.
Academic Article	Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans.
Academic Article	The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C.?elegans.
Academic Article	HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans.
Academic Article	PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans.
Academic Article	Microinjection for precision genome editing in Caenorhabditis elegans.
Academic Article	Cues from mRNA splicing prevent default Argonaute silencing in C.?elegans.
Academic Article	5'-Modifications improve potency and efficacy of DNA donors for precision genome editing.
Concept	Gene Editing
Concept	Epigenomics
Concept	Nucleotide Motifs
Concept	Transcriptome
Concept	Sumoylation
Concept	RNA, Small Untranslated
Concept	Argonaute Proteins
Concept	Clustered Regularly Interspaced Short Palindromic Repeats
Concept	CRISPR-Cas Systems
Academic Article	A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing.
Academic Article	The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing.
Academic Article	Casein kinase II promotes piRNA production through direct phosphorylation of USTC component TOFU-4.
Academic Article	Resistance to Cry14A family Bacillus thuringiensis crystal proteins in Caenornabditis elegans operates via the nhr-31 transcription factor and vacuolar-type ATPase pathway.

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