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One or more keywords matched the following properties of Gazzinelli, Ricardo


My research program is developed at the Division of Infectious Diseases and Immunology, Department of Medicine, UMASS Medical School, Worcester, USA and at Oswaldo Cruz Foundation-Minas, in belo Horizonte, Brazil.

Broadly, I am interested in understanding the immunological mechanisms that warrant host resistance to infection and at the same time prevent immune mediated tissue damage and pathology in parasitic diseases. The main areas of scientific research carried in my lab are on: (i) the role innate immunity on host resistance and pathogenesis to infection with protozoan parasites; (ii) the mechanisms of cytotoxic T cells in resistance to infection; and (iii) the development of recombinant vaccines that induce cell-mediated immunity and protect against protozoan infections. When possible, we try to address our questions regarding host-parasite interactions, employing cellular systems, experimental rodent models and well-characterized patients undergoing specific protozoan infection.

Main Projects:

Role of TLRs, inflammasome and inflammatory caspses in malaria pathogenesis

Role of monocyte-derived dendritic cells in malária

The influence of the circadian cycle on inflammation, metabolismo and Plasmodium infection

The role of IRAKs and Myddosomes in infection with T. gondii

Development of the recombinant-A2 vaccine for visceral leishmaniasis

Development of the recombinant-ASP2/TS vaccine for visceral leishmaniasis

My current research is supported by Conselho Nacional de Desenvolvimento Cinetifico e Tecnologico (CNPq), Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) and the National Institutes of Health (NIH).

One or more keywords matched the following items that are connected to Gazzinelli, Ricardo
Item TypeName
Academic Article Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.
Academic Article Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism.
Academic Article Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi.
Academic Article The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease.
Academic Article UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major.
Concept Host-Parasite Interactions
Academic Article The genome of Anopheles darlingi, the main neotropical malaria vector.
Academic Article RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms.
Academic Article Leishmania amazonensis Engages CD36 to Drive Parasitophorous Vacuole Maturation.
Academic Article Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection.
Academic Article Daily Rhythms of TNFa Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.
Academic Article The immunology of Plasmodium vivax malaria.
Academic Article Periodic Parasites and Daily Host Rhythms.
Academic Article ?d T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis.
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  • Host Parasite Interactions