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One or more keywords matched the following properties of Gazzinelli, Ricardo
keywords Malaria, Plasmodium vivax


My research program is developed at the Division of Infectious Diseases and Immunology, Department of Medicine, UMASS Medical School, Worcester, USA and at Oswaldo Cruz Foundation-Minas, in belo Horizonte, Brazil.

Broadly, I am interested in understanding the immunological mechanisms that warrant host resistance to infection and at the same time prevent immune mediated tissue damage and pathology in parasitic diseases. The main areas of scientific research carried in my lab are on: (i) the role innate immunity on host resistance and pathogenesis to infection with protozoan parasites; (ii) the mechanisms of cytotoxic T cells in resistance to infection; and (iii) the development of recombinant vaccines that induce cell-mediated immunity and protect against protozoan infections. When possible, we try to address our questions regarding host-parasite interactions, employing cellular systems, experimental rodent models and well-characterized patients undergoing specific protozoan infection.

Main Projects:

Role of TLRs, inflammasome and inflammatory caspses in malaria pathogenesis

Role of monocyte-derived dendritic cells in malária

The influence of the circadian cycle on inflammation, metabolismo and Plasmodium infection

The role of IRAKs and Myddosomes in infection with T. gondii

Development of the recombinant-A2 vaccine for visceral leishmaniasis

Development of the recombinant-ASP2/TS vaccine for visceral leishmaniasis

My current research is supported by Conselho Nacional de Desenvolvimento Cinetifico e Tecnologico (CNPq), Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) and the National Institutes of Health (NIH).

Post Docs


Caroline Junqueira, PhD - Staff Scientist

  • Camila Brabosa, PhD student - Mapping of CD8 T cell-specifc Epitopes from Malaria Blood Stage
  • Gregorio Almeida, DVM, PhD - Immunology of Asymptomatic Malaria
  • Guilherme Maia, PhD - Innate Lymphocytes in Malaria
  • Isabella Hirako, PhD - Monocyte-Derived Dendritic Cells in Malaria
  • Júlia Castro, MSc student - Chagas Disease Vaccine
  • Larissa Pereira, MSc student - Inflammatory Caspases in Malaria
  • Kely Mateucci, PhD - Monocyte-Derived Dendritic Cells Metabolism in Malaria
  • Milton Pereira, PhD - Caspases and inflammasomes in Malaria and Chagas Disease
  • Natalia Satchiko Souza, PhD - CD8+ T cells in malaria


  • Danielle Durso, PhD - IRAKs and Myddosomes in host resistance to T. gondii
  • Patricia Assis, PhD - Host Clock genes and Malaria
  • Ogooluwa Ojelabi, PhD - Glucose Metabolism and Malaria
One or more keywords matched the following items that are connected to Gazzinelli, Ricardo
Item TypeName
Academic Article Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
Academic Article Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.
Academic Article Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria.
Academic Article Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Academic Article Neutrophil paralysis in Plasmodium vivax malaria.
Concept Malaria
Concept Malaria Vaccines
Concept Malaria, Cerebral
Concept Malaria, Falciparum
Concept Malaria, Vivax
Academic Article The genome of Anopheles darlingi, the main neotropical malaria vector.
Academic Article Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Academic Article Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Academic Article The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria.
Academic Article Innate sensing of malaria parasites.
Academic Article Induction of Inhibitory Receptors on T Cells During Plasmodium vivax Malaria Impairs Cytokine Production.
Academic Article DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14+ CD16+ CD64high CD32low Inflammatory Monocytes from Malaria Patients.
Academic Article Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria.
Academic Article Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria.
Academic Article Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity.
Academic Article T follicular helper cells regulate the activation of B lymphocytes and antibody production during Plasmodium vivax infection.
Academic Article Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria.
Academic Article Daily Rhythms of TNF? Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.
Academic Article The emergence of pathogenic TNF/iNOS producing dendritic cells (Tip-DCs) in a malaria model of acute respiratory distress syndrome (ARDS) is dependent on CCR4.
Academic Article Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax-infected reticulocytes.
Academic Article Monocyte-derived dendritic cells in malaria.
Academic Article The immunology of Plasmodium vivax malaria.
Academic Article Periodic Parasites and Daily Host Rhythms.
Academic Article Contributions of IFN-? and granulysin to the clearance of Plasmodium yoelii blood stage.
Academic Article Caspase-8 mediates inflammation and disease in rodent malaria.
Academic Article Author Correction: Caspase-8 mediates inflammation and disease in rodent malaria.
Academic Article Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen.
Academic Article ?? T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis.
Academic Article Plasmodium vivax Infection Alters Mitochondrial Metabolism in Human Monocytes.
Academic Article Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi.
Search Criteria
  • Malaria