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Rotation Projects

Rotation projects are available to study chromatin structure and function.

Project 1. Measure histone dynamics in yeast.

Histone dynamics play major roles in chromatin metabolism and in the inheritance of chromatin states. To measure histone replacement rates in yeast, we have created yeast strains carrying inducible epitope-tagged histones H3 and H2A. Using microarrays, we will measure histone replacement rates in a variety of mutant yeast to ascertain the role of various chromatin remodeling factors in histone exchange reactions.

Project 2. Characterize mechanisms for epigenetic inheritance in yeast.

We have identified a variety of genes whose expression state in yeast is epigenetically heritable. We will screen the yeast genome for genes that affect the inheritance of these expression patterns.

Project 3. Measure histone dynamics in embryonic stem cells.

Embryonic stem cells are pluripotent cells that can give rise to every type of cell in the adult animal. The role of chromatin structure in maintaining this pluripotent state is poorly understood, but it appears that stem cell chromatin is exceptionally labile relative to that in differentiated cells. We will create stem cell lines with inducible tagged histones to measure histone replacement rates across the mouse genome.

One or more keywords matched the following items that are connected to Rando, Oliver
Item TypeName
Academic Article Second messenger control of chromatin remodeling.
Academic Article Chromatin remodelling at promoters suppresses antisense transcription.
Academic Article Genome-wide views of chromatin structure.
Academic Article Nucleosome positioning: how is it established, and why does it matter?
Academic Article Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex.
Academic Article Control of chromatin structure by spt6: different consequences in coding and regulatory regions.
Academic Article A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast.
Academic Article A functional evolutionary approach to identify determinants of nucleosome positioning: a unifying model for establishing the genome-wide pattern.
Academic Article Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors.
Academic Article Toward a unified physical model of nucleosome patterns flanking transcription start sites.
Academic Article A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme.
Academic Article Oliver Rando: taking chromatin analysis to the genomic scale. Interview by Ruth Williams.
Academic Article Overlapping regulation of CenH3 localization and histone H3 turnover by CAF-1 and HIR proteins in Saccharomyces cerevisiae.
Academic Article Global regulation of H2A.Z localization by the INO80 chromatin-remodeling enzyme is essential for genome integrity.
Academic Article Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells.
Academic Article Chromatin and transcription in yeast.
Academic Article NURDs are required for diversity.
Academic Article Systematic dissection of roles for chromatin regulators in a yeast stress response.
Concept Chromatin Assembly and Disassembly
Academic Article Mechanisms underlying nucleosome positioning in vivo.
Academic Article Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF.
Academic Article High-resolution chromatin dynamics during a yeast stress response.
Academic Article DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells.
Academic Article LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo.
Academic Article Condensin-Dependent Chromatin Compaction Represses Transcription Globally during Quiescence.
Academic Article tRNA Genes Affect Chromosome Structure and Function via Local Effects.
Academic Article Profiling of Pluripotency Factors in Single Cells and Early Embryos.
Academic Article Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding.
Academic Article Histone exchange is associated with activator function at transcribed promoters and with repression at histone loci.
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  • Chromatin Assembly and Disassembly