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Search Results to Shan Lu MD, PhD

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Academic Background

MD, 1982, Nanjing Medical College
PhD, 1991, UMass Worcester

Immunogenicity of Protein Antigens

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Shan LuOur main interest is to understand the immunogenicity of proteinantigens. The human immunodeficiency virus type-1 (HIV-1) envelopeproteins (Env) is used as a model system in our lab. Env, a two-subunitprotein, is generated during the posttranslational cleavage processfrom a single precursor polyprotein. Env heterodimers are furtherorganized into an oligomeric complex. Env conformation is criticalfor the interaction of HIV-1 with a number of viral receptors. Our work is to understand the immunogenicity of various Env subunitsfrom different HIV-1 strains and to find the Env structures thatHIV-1 uses to escape from host immune surveillance. Such informationwill be used to design noval HIV-1 vaccines. Direct DNA immunizationusing eukaryotic expression vectors to make proteins in vivo isa unique approach we have been using to study the immunogenicityof protein antigens. We are also working to further improve thisevolving technology by studying the roles of cytokines and adjuvantsin inducing the desired immune responses by direct DNA immunization.


One or more keywords matched the following items that are connected to Lu, Shan

Item TypeName
Academic Article Epitope mapping and biological function analysis of antibodies produced by immunization of mice with an inactivated Chinese isolate of severe acute respiratory syndrome-associated coronavirus (SARS-CoV).
Academic Article Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1.
Academic Article Increased immunogenicity of human immunodeficiency virus gp120 engineered to express Galalpha1-3Galbeta1-4GlcNAc-R epitopes.
Academic Article DNA vaccines expressing glycoprotein complex II antigens gM and gN elicited neutralizing antibodies against multiple human cytomegalovirus (HCMV) isolates.
Academic Article Current progress of DNA vaccine studies in humans.
Academic Article Immunogenicity of DNA vaccines in humans: it takes two to tango.
Academic Article Improved induction of antibodies against key neutralizing epitopes by human immunodeficiency virus type 1 gp120 DNA prime-protein boost vaccination compared to gp120 protein-only vaccination.
Academic Article Heterologous HA DNA vaccine prime--inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses.
Academic Article Increased immunogenicity of HIV-1 p24 and gp120 following immunization with gp120/p24 fusion protein vaccine expressing alpha-gal epitopes.
Academic Article Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity.
Academic Article Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates.
Academic Article Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus spike glycoprotein produced from the mammalian expression system.
Academic Article Immunogenicity and protection efficacy of subunit-based smallpox vaccines using variola major antigens.
Academic Article The safety and tolerability of an HIV-1 DNA prime-protein boost vaccine (DP6-001) in healthy adult volunteers.
Academic Article Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.
Academic Article Heterologous prime-boost vaccination.
Concept Immunization Schedule
Concept Immunization
Concept Immunization, Secondary
Academic Article DNA immunization.
Academic Article Reduced MyD88 dependency of ISCOMATRIX™ adjuvant in a DNA prime-protein boost HIV vaccine.
Academic Article Contribution of TLR4 and MyD88 for adjuvant monophosphoryl lipid A (MPLA) activity in a DNA prime-protein boost HIV-1 vaccine.
Academic Article Pilot Study on the Use of DNA Priming Immunization to Enhance Y. pestis LcrV-Specific B Cell Responses Elicited by a Recombinant LcrV Protein Vaccine.
Academic Article DNA Immunization for HIV Vaccine Development.
Academic Article The dynamics of immunoglobulin V-gene usage and clonotype expansion in mice after prime and boost immunizations as analyzed by NGS.

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