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One or more keywords matched the following properties of Lu, Shan

Academic Background

MD, 1982, Nanjing Medical College
PhD, 1991, UMass Worcester

Immunogenicity of Protein Antigens

Shan LuOur main interest is to understand the immunogenicity of proteinantigens. The human immunodeficiency virus type-1 (HIV-1) envelopeproteins (Env) is used as a model system in our lab. Env, a two-subunitprotein, is generated during the posttranslational cleavage processfrom a single precursor polyprotein. Env heterodimers are furtherorganized into an oligomeric complex. Env conformation is criticalfor the interaction of HIV-1 with a number of viral receptors. Our work is to understand the immunogenicity of various Env subunitsfrom different HIV-1 strains and to find the Env structures thatHIV-1 uses to escape from host immune surveillance. Such informationwill be used to design noval HIV-1 vaccines. Direct DNA immunizationusing eukaryotic expression vectors to make proteins in vivo isa unique approach we have been using to study the immunogenicityof protein antigens. We are also working to further improve thisevolving technology by studying the roles of cytokines and adjuvantsin inducing the desired immune responses by direct DNA immunization.

One or more keywords matched the following items that are connected to Lu, Shan
Item TypeName
Academic Article Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1.
Academic Article Increased immunogenicity of human immunodeficiency virus gp120 engineered to express Galalpha1-3Galbeta1-4GlcNAc-R epitopes.
Academic Article Improved induction of antibodies against key neutralizing epitopes by human immunodeficiency virus type 1 gp120 DNA prime-protein boost vaccination compared to gp120 protein-only vaccination.
Academic Article Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates.
Academic Article Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates.
Academic Article Polyvalent HIV-1 Env vaccine formulations delivered by the DNA priming plus protein boosting approach are effective in generating neutralizing antibodies against primary human immunodeficiency virus type 1 isolates from subtypes A, B, C, D and E.
Academic Article Progress on the induction of neutralizing antibodies against HIV type 1 (HIV-1).
Concept Acquired Immunodeficiency Syndrome
Concept gag Gene Products, Human Immunodeficiency Virus
Concept env Gene Products, Human Immunodeficiency Virus
Academic Article Post-translational intracellular trafficking determines the type of immune response elicited by DNA vaccines expressing Gag antigen of Human Immunodeficiency Virus Type 1 (HIV-1).
Academic Article Fc Receptor-Mediated Activities of Env-Specific Human Monoclonal Antibodies Generated from Volunteers Receiving the DNA Prime-Protein Boost HIV Vaccine DP6-001.
Academic Article HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.
Search Criteria
  • X Linked Combined Immunodeficiency Diseases