Search Result Details

Back to Search Results

This page shows the details of why an item matched the keywords from your search.

Search Results

Zhu, Lihua

One or more keywords matched the following properties of Zhu, Lihua

Property	Value
overview	Academic Background Lihua Julie Zhu obtained her Ph.D. in Nutritional Sciences from the University of Wisconsin-Madison in 1999, and her M.S. in Computer Science from DePaul University in Chicago in 2001. She joined the Bioinformatics Core of the Robert H. Lurie Comprehensive Cancer Center (RHLCCC) of Northwestern University in 2001, where she was the Director of Bioinformatics Consulting Core from 2003 to 2005 and the Director of Clinical Informatics Group from 2005 to 2007. She joined the University of Massachusetts Medical School (UMMS) as the head of Bioinformatics core of Program in Gene Function and Expression (PGFE) in 2007. Dr. Zhu is currently a professor and the head of Bioinformatics Core in the Department of Molecular, Cell and Cancer Biology (MCCB) of UMMS. Computational Biology and Bioinformatics We are interested in the understanding of gene regulation and cancer etiology, biomarker discovery, and development and application of genome editing technology by mining and integrating various high-throughput datasets such as WGS, ChIP-seq, bulk and single cell RNA-seq and ATAC-seq, miRNA-seq, Hi-C, shRNA-seq, PAS-seq, NAD-seq and GUIDE-seq. Our expertise is algorithm and computational tool development. We have developed more than 20 computational tools, including a dozen Bioconductor packages. These tools encompass functionalities such as RNA-seq data analysis, scATAC-seq data analysis, gRNA design and offtarget analysis, machine learning applications, peak calling, proteomics data analysis, motif alignment, quality assessment, annotation, model selection, data integration and visualization.

Property

Value

overview

Academic Background

Lihua Julie Zhu obtained her Ph.D. in Nutritional Sciences from the University of Wisconsin-Madison in 1999, and her M.S. in Computer Science from DePaul University in Chicago in 2001. She joined the Bioinformatics Core of the Robert H. Lurie Comprehensive Cancer Center (RHLCCC) of Northwestern University in 2001, where she was the Director of Bioinformatics Consulting Core from 2003 to 2005 and the Director of Clinical Informatics Group from 2005 to 2007. She joined the University of Massachusetts Medical School (UMMS) as the head of Bioinformatics core of Program in Gene Function and Expression (PGFE) in 2007. Dr. Zhu is currently a professor and the head of Bioinformatics Core in the Department of Molecular, Cell and Cancer Biology (MCCB) of UMMS.

Computational Biology and Bioinformatics

We are interested in the understanding of gene regulation and cancer etiology, biomarker discovery, and development and application of genome editing technology by mining and integrating various high-throughput datasets such as WGS, ChIP-seq, bulk and single cell RNA-seq and ATAC-seq, miRNA-seq, Hi-C, shRNA-seq, PAS-seq, NAD-seq and GUIDE-seq. Our expertise is algorithm and computational tool development. We have developed more than 20 computational tools, including a dozen Bioconductor packages. These tools encompass functionalities such as RNA-seq data analysis, scATAC-seq data analysis, gRNA design and offtarget analysis, machine learning applications, peak calling, proteomics data analysis, motif alignment, quality assessment, annotation, model selection, data integration and visualization.

One or more keywords matched the following items that are connected to Zhu, Lihua

Item Type	Name
Academic Article	Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions.
Academic Article	Nuclear factor-kappaB-mediated transforming growth factor-beta-induced expression of vimentin is an independent predictor of biochemical recurrence after radical prostatectomy.
Academic Article	AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1.
Academic Article	Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4.
Academic Article	Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons.
Academic Article	Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis.
Academic Article	Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis.
Academic Article	Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites.
Academic Article	Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex.
Academic Article	BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription.
Academic Article	miR-221 is required for endothelial tip cell behaviors during vascular development.
Academic Article	Non-canonical TAF complexes regulate active promoters in human embryonic stem cells.
Academic Article	A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells.
Academic Article	Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development.
Concept	Gene Expression Regulation, Fungal
Concept	Down-Regulation
Concept	Up-Regulation
Concept	Gene Expression Regulation, Leukemic
Concept	Gene Expression Regulation, Developmental
Concept	Gene Expression Regulation
Concept	Gene Expression Regulation, Neoplastic
Academic Article	miR-146a promotes the initiation and progression of melanoma by activating Notch signaling.
Academic Article	A large-scale RNAi-based mouse tumorigenesis screen identifies new lung cancer tumor suppressors that repress FGFR signaling.
Academic Article	MicroRNA-378 controls classical brown fat expansion to counteract obesity.
Academic Article	A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia.
Academic Article	TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.
Academic Article	Jmjd3-Mediated H3K27me3 Dynamics Orchestrate Brown Fat Development and Regulate White Fat Plasticity.
Academic Article	A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination.
Academic Article	U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3' End Formation.
Academic Article	Regulation of X-linked gene expression during early mouse development by Rlim.
Academic Article	Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors.
Academic Article	Activation of WNT/?-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61.
Academic Article	MELK Promotes Melanoma Growth by Stimulating the NF-?B Pathway.
Academic Article	motifStack for the analysis of transcription factor binding site evolution.
Academic Article	VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP ?2-chimaerin.
Academic Article	C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2.
Academic Article	foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish.
Academic Article	Two contrasting classes of nucleolus-associated domains in mouse fibroblast heterochromatin.
Academic Article	The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression.
Academic Article	Gene expression signature of atypical breast hyperplasia and regulation by SFRP1.
Academic Article	Conserved microRNA mediates heating tolerance in germ cells versus surrounding somatic cells.
Academic Article	Genomic Characterization of Endothelial Enhancers Reveals a Multifunctional Role for NR2F2 in Regulation of Arteriovenous Gene Expression.
Academic Article	The coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network.
Academic Article	KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity.
Academic Article	OneStopRNAseq: A Web Application for Comprehensive and Efficient Analyses of RNA-Seq Data.
Academic Article	UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans.
Academic Article	Prostaglandin E2 stimulates cAMP signaling and resensitizes human leukemia cells to glucocorticoid-induced cell death.
Academic Article	Consequences of aneuploidy in human fibroblasts with trisomy 21.
Academic Article	Hinfp is a guardian of the somatic genome by repressing transposable elements.
Academic Article	Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma.
Academic Article	Calcineurin promotes adaptation to chronic stress through two distinct mechanisms.
Academic Article	The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma.

Search Criteria

Up Regulation