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Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease.
ESCRT dysfunction compromises endoplasmic reticulum maturation and autophagosome biogenesis in Drosophila.
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development.