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Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.
The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice.
Casein Kinase II
CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells.