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One or more keywords matched the following properties of Kelliher, Michelle
Rotation Projects

Please visit the Kelliher Lab website at: http://labs.umassmed.edu/kelliherlab/ to learn more about our current research areas.


1. Identify genes/pathways that mediate leukemia-initiating cell survival


2. Understand the molecular basis of glucocorticoid resistance in leukemia


3. Examine contribution of RIPK1 kinase in inflammatory and autoimmune disease mouse models.


4.  Reveal tissue-specific roles for RIPK1 in cell death and inflammation. Use conditional Ripk1 allele to investigate effects of Ripk1       deletion in liver, pancreas and antigen presenting cells.


One or more keywords matched the following items that are connected to Kelliher, Michelle
Item TypeName
Academic Article Calorie restriction, stress and the ubiquitin-dependent pathway in mouse livers.
Academic Article Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene.
Academic Article RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation.
Academic Article p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice.
Academic Article The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice.
Academic Article A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.
Academic Article Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
Academic Article The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death.
Academic Article NF-kappaB activation in premalignant mouse tal-1/scl thymocytes and tumors.
Academic Article Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.
Academic Article The TLX1 oncogene drives aneuploidy in T cell transformation.
Academic Article Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.
Concept CD8-Positive T-Lymphocytes
Concept T-Lymphocyte Subsets
Concept Organ Specificity
Concept T-Lymphocytes
Concept Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Concept Lymphocytes
Concept Lymphocyte Activation
Concept CD4-Positive T-Lymphocytes
Concept Substrate Specificity
Concept B-Lymphocytes
Academic Article High-Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML.
Academic Article Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.
Academic Article Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.
Academic Article NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies.
Academic Article Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.
Academic Article Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia.
Search Criteria
  • Lymphocyte
  • Specific
  • Protein Tyrosine Kinase
  • p56 lck