| Item Type | Name |
|
Academic Article
|
Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.
|
|
Academic Article
|
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal.
|
|
Academic Article
|
Calorie restriction, stress and the ubiquitin-dependent pathway in mouse livers.
|
|
Academic Article
|
The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation.
|
|
Academic Article
|
The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase.
|
|
Academic Article
|
Aging, calorie restriction and ubiquitin-dependent proteolysis in the livers of Emory mice.
|
|
Academic Article
|
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.
|
|
Academic Article
|
The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.
|
|
Academic Article
|
TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.
|
|
Academic Article
|
RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation.
|
|
Academic Article
|
p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice.
|
|
Academic Article
|
Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination.
|
|
Academic Article
|
Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.
|
|
Academic Article
|
RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR.
|
|
Academic Article
|
The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice.
|
|
Academic Article
|
NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.
|
|
Academic Article
|
A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.
|
|
Academic Article
|
A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.
|
|
Academic Article
|
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
|
|
Academic Article
|
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
|
|
Academic Article
|
The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death.
|
|
Academic Article
|
TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia.
|
|
Academic Article
|
RIP1-driven autoinflammation targets IL-1a independently of inflammasomes and RIP3.
|
|
Academic Article
|
The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.
|
|
Academic Article
|
NF-kappaB activation in premalignant mouse tal-1/scl thymocytes and tumors.
|
|
Academic Article
|
The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase.
|
|
Academic Article
|
Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.
|
|
Academic Article
|
Activating Notch1 mutations in mouse models of T-ALL.
|
|
Academic Article
|
NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells.
|
|
Academic Article
|
Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc.
|
|
Academic Article
|
NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.
|
|
Academic Article
|
Targeting the Notch1 and mTOR pathways in a mouse T-ALL model.
|
|
Academic Article
|
Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide.
|
|
Academic Article
|
Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.
|
|
Academic Article
|
Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.
|
|
Concept
|
Protein Binding
|
|
Concept
|
Amyloid beta-Protein Precursor
|
|
Concept
|
Protein Processing, Post-Translational
|
|
Concept
|
Tumor Suppressor Protein p14ARF
|
|
Concept
|
Ubiquitin-Protein Ligases
|
|
Concept
|
Unfolded Protein Response
|
|
Concept
|
Tumor Suppressor Protein p53
|
|
Concept
|
Proto-Oncogene Protein c-fli-1
|
|
Concept
|
Mitogen-Activated Protein Kinases
|
|
Concept
|
Calcium-Calmodulin-Dependent Protein Kinases
|
|
Concept
|
p38 Mitogen-Activated Protein Kinases
|
|
Concept
|
Retinoblastoma Protein
|
|
Concept
|
Protein Tyrosine Phosphatase, Non-Receptor Type 6
|
|
Concept
|
Protein Kinase Inhibitors
|
|
Concept
|
Mitogen-Activated Protein Kinase 1
|
|
Concept
|
Protein Biosynthesis
|
|
Concept
|
Protein Kinases
|
|
Concept
|
GTP-Binding Protein alpha Subunits, Gs
|
|
Concept
|
BH3 Interacting Domain Death Agonist Protein
|
|
Concept
|
RNA-Binding Protein EWS
|
|
Concept
|
Nod2 Signaling Adaptor Protein
|
|
Concept
|
Fas-Associated Death Domain Protein
|
|
Concept
|
Receptor-Interacting Protein Serine-Threonine Kinases
|
|
Concept
|
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
|
|
Concept
|
Protein Structure, Tertiary
|
|
Concept
|
Protein Multimerization
|
|
Concept
|
Protein Stability
|
|
Concept
|
Amyloid Precursor Protein Secretases
|
|
Concept
|
JNK Mitogen-Activated Protein Kinases
|
|
Concept
|
bcl-X Protein
|
|
Concept
|
Nod1 Signaling Adaptor Protein
|
|
Concept
|
Receptor-Interacting Protein Serine-Threonine Kinase 2
|
|
Concept
|
SUMO-1 Protein
|
|
Academic Article
|
Activation of NOD receptors by Neisseria gonorrhoeae modulates the innate immune response.
|
|
Academic Article
|
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
|
|
Academic Article
|
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
|
|
Academic Article
|
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
|
|
Academic Article
|
NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro.
|
|
Academic Article
|
Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo.
|
|
Academic Article
|
Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.
|
|
Academic Article
|
Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199.
|
|
Academic Article
|
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.
|
|
Academic Article
|
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.
|
|
Academic Article
|
Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis.
|
|
Academic Article
|
Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice.
|
|
Academic Article
|
NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
|
|
Academic Article
|
NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-?B-Dependent and -Independent Functions.
|
|
Academic Article
|
CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN.
|
|
Academic Article
|
RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4.
|
|
Academic Article
|
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
|
|
Academic Article
|
High-Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML.
|
|
Academic Article
|
Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis.
|
|
Academic Article
|
CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells.
|
|
Academic Article
|
Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.
|
|
Academic Article
|
JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.
|
|
Academic Article
|
Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-? Synthesis Induced by Lipopolysaccharide.
|
|
Academic Article
|
RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia.
|
|
Academic Article
|
RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome.
|
|
Academic Article
|
Dysfunctional intracellular calcium homoeostasis: a central cause of neurodegeneration in Alzheimer's disease.
|
|
Academic Article
|
The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.
|
|
Academic Article
|
Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.
|
|
Academic Article
|
RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.
|
|
Academic Article
|
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
|
|
Academic Article
|
UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response.
|
|
Academic Article
|
Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.
|
|
Academic Article
|
NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263.
|
|
Academic Article
|
Analyzing Necroptosis Using an RIPK1 Kinase Inactive Mouse Model of TNF Shock.
|
|
Academic Article
|
BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.
|
|
Academic Article
|
BID-ding on necroptosis in MDS.
|
|
Academic Article
|
RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-?B Activation.
|
|
Academic Article
|
Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.
|
|
Academic Article
|
Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke.
|
|
Academic Article
|
Prostaglandin E2 stimulates cAMP signaling and resensitizes human leukemia cells to glucocorticoid-induced cell death.
|
|
Academic Article
|
T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.
|
|
Concept
|
NLR Family, Pyrin Domain-Containing 3 Protein
|
|
Concept
|
Nanog Homeobox Protein
|
|
Concept
|
Bcl-2-Like Protein 11
|
|
Concept
|
Tumor Necrosis Factor alpha-Induced Protein 3
|
|
Concept
|
T-Cell Acute Lymphocytic Leukemia Protein 1
|
|
Concept
|
F-Box-WD Repeat-Containing Protein 7
|
|
Concept
|
WNK Lysine-Deficient Protein Kinase 1
|
|
Concept
|
Protein-Arginine Deiminases
|
|
Concept
|
Transcription Factor 7-Like 1 Protein
|
|
Concept
|
Myeloid Cell Leukemia Sequence 1 Protein
|
|
Academic Article
|
Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia.
|
|
Academic Article
|
TBK1 inhibition unleashes RIPK1, resensitizing tumors to immunotherapy.
|
|
Academic Article
|
ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice.
|
|
Academic Article
|
The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance.
|
|
Academic Article
|
Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma.
|
|
Academic Article
|
The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma.
|
|
Academic Article
|
Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance.
|