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Mao, Junhao
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BIOGRAPHY

JunhaoMao

Junhao Mao received his Ph.D. degree from the University of Rochester in 2003. He did his postdoctoral research at Harvard University from 2003 to 2008, where he was supported by the fellowships from Damon Runyon Cancer Research Foundation and Charles A. King Trust. He joined the University of Massachusetts Medical School in fall 2008. Dr. Mao was also a recipient of the Charles H. Hood Foundation Child Health Research Award in 2009, American Cancer Society Research Scholar Award in 2011, Pancreatic Cancer Alliance Research Award in 2015, and Sanofi iAward in 2020. 

RESEARCH

My lab is interested in investigating the signaling mechanisms that underlie tissue homeostasis and tumorigenesis.  Our work is focused on several key developmental pathways including Hippo, Wnt and Hedgehog signaling.  We use a combination of molecular, cellular and mouse genetic approaches to dissect their roles in stem cell/progenitor function, and understand how dysregulation of these pathways contributes to tumor initiation and progression.

 

 

 

 
One or more keywords matched the following items that are connected to Mao, Junhao
Item TypeName
Academic Article Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation.
Academic Article A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.
Academic Article The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis.
Academic Article GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation.
Academic Article TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPa function.
Academic Article Mutations in Hedgehog pathway genes in fetal rhabdomyomas.
Academic Article Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
Academic Article Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis.
Concept Muscle Neoplasms
Concept Neoplasm Metastasis
Concept Uveal Neoplasms
Concept Biomarkers, Tumor
Concept Neoplasms, Experimental
Concept Colorectal Neoplasms
Concept Pancreatic Neoplasms
Concept Stomach Neoplasms
Concept Bone Neoplasms
Concept Tumor Cells, Cultured
Concept Gastrointestinal Stromal Tumors
Concept Liver Neoplasms
Concept Vascular Neoplasms
Concept Neoplasm Invasiveness
Concept Neoplasms, Muscle Tissue
Concept DNA, Neoplasm
Concept Neoplasm Proteins
Concept Neoplasm Staging
Concept Kidney Neoplasms
Concept Drug Resistance, Neoplasm
Concept Neoplasm Transplantation
Concept Breast Neoplasms
Concept Neoplasms
Concept Skin Neoplasms
Concept National Cancer Institute (U.S.)
Concept Cell Line, Tumor
Concept Tumor Suppressor Proteins
Concept Gastrointestinal Neoplasms
Academic Article A laminin 511 matrix is regulated by TAZ and functions as the ligand for the a6B?1 integrin to sustain breast cancer stem cells.
Academic Article Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity.
Academic Article Tead and AP1 Coordinate Transcription and Motility.
Academic Article Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.
Academic Article Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.
Academic Article IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis.
Academic Article YAP drives cutaneous squamous cell carcinoma formation and progression.
Academic Article Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis.
Academic Article YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression.
Academic Article Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.
Academic Article Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.
Academic Article The National Cancer Institute's Conference on Acupuncture for Symptom Management in Oncology: State of the Science, Evidence, and Research Gaps.
Academic Article Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma.
Academic Article Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma.
Academic Article Acupuncture for Quality of Life in Gastric Cancer Patients Undergoing Adjuvant Chemotherapy.
Concept Cancer Survivors
Academic Article PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis.
Academic Article Pharmacological blockade of TEAD-YAP reveals its therapeutic limitation in cancer cells.
Academic Article Two Hippo signaling modules orchestrate liver size and tumorigenesis.
Academic Article Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors.
Academic Article Clinical and genetic risk factors for aromatase inhibitor-associated arthralgia in breast cancer survivors.
Academic Article Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial.
Academic Article State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research-NCI Strategic Workshop Highlights of Discussion Report.
Academic Article Growth of Integrative Medicine at Leading Cancer Centers Between 2009 and 2016: A Systematic Analysis of NCI-Designated Comprehensive Cancer Center Websites.
Academic Article A Comprehensive Definition for Integrative Oncology.
Academic Article Prevalence and risk factors for fatigue among breast cancer survivors on aromatase inhibitors.
Academic Article Integrative Oncology.
Academic Article Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline.
Academic Article Advancing the science of integrative oncology to inform patient-centered care for cancer survivors.
Academic Article Integrative oncology: Addressing the global challenges of cancer prevention and treatment.
Academic Article Genetic predictors to acupuncture response for hot flashes: an exploratory study of breast cancer survivors.
Academic Article Challenges in a Technology-Based Cancer Pain Management Program Among Asian American Breast Cancer Survivors.
Academic Article A randomized controlled trial testing a virtual program for Asian American women breast cancer survivors.
Academic Article KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis.
Academic Article Hippo Signaling Is Essential for the Maintenance of Zona Glomerulosa Cell Fate in the Murine Adrenal Cortex.
Academic Article Genetic Predictors of Response to Acupuncture or Cognitive Behavioral Therapy for Insomnia in Cancer Survivors: An Exploratory Analysis.
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  • Neoplasms