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Landers, John
One or more keywords matched the following properties of Landers, John
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Biography:

1986-1990B.S. Rensselaer Polytechnic Institute

1990-1995Ph.D. University of Pennsylvania

1995-1997Postdoctoral Research Associate Massachusetts Institute of Technology

1997-1999Postdoctoral Research Fellow Massachusetts Institute of Technology

1999-2005Vice President & Chief Scientific OfficerPolyGenyx, Inc.

2003-2008Assistant Professor of Neurology Harvard Medical School, MGH

2003-Director of ALS Genetics Day Neuromuscular Research Laboratory

2008-Associate Professor of Neurology UMASSMedical School

Research Description:

Genetics of Familial and Sporadic ALS

Landers

Amyotrophic lateral sclerosis (ALS) is a uniformly lethal, age-dependent neurodegenerative disorder with a typical survival of 2 to 5 years. Our laboratory is focused on using high-throughput genomic technologies to identify the genes involved in the development of sporadic and familial ALS. Most recently, our lab has utilized high-density SNP arrays to analyze over 300,000 DNA polymorphisms within ~4,000 subjects to test for their association to sporadic ALS. Through our efforts, we have identified KIFAP3, a kinesin II complex member responsible for fast anterograde axonal transport, as a modifier of survival in sporadic ALS. Homozygotes for the favorable allele located in the promoter region of KIFAP3 display a survival advantage of 14.0 months, a substantial increment (~30%) in this disease. Currently, our efforts are focused on understanding how KIFAP3 influences survival and how we can use this information to aid in the development of strategies to extend the lifespan of ALS patients.
One or more keywords matched the following items that are connected to Landers, John
Item TypeName
Academic Article A common haplotype within the PON1 promoter region is associated with sporadic ALS.
Academic Article Paraoxonase gene mutations in amyotrophic lateral sclerosis.
Academic Article Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.
Academic Article Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.
Academic Article Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
Academic Article A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts.
Academic Article Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.
Academic Article Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
Academic Article DNA sequence analysis of the conserved region around the SOD1 gene locus in recessively inherited ALS.
Academic Article Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
Academic Article The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci.
Academic Article RNA processing pathways in amyotrophic lateral sclerosis.
Academic Article A large genome scan for rare CNVs in amyotrophic lateral sclerosis.
Academic Article Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets.
Academic Article Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.
Academic Article Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq.
Concept Amyotrophic Lateral Sclerosis
Academic Article The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder.
Academic Article No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.
Academic Article A blinded international study on the reliability of genetic testing for GGGGCC-repeat expansions in C9orf72 reveals marked differences in results among 14 laboratories.
Academic Article Novel mutations support a role for Profilin 1 in the pathogenesis of ALS.
Academic Article The distinct genetic pattern of ALS in Turkey and novel mutations.
Academic Article Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.
Academic Article TUBA4A gene analysis in sporadic amyotrophic lateral sclerosis: identification of novel mutations.
Academic Article Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients.
Academic Article Structural basis for mutation-induced destabilization of profilin 1 in ALS.
Academic Article Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS.
Academic Article CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.
Academic Article Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis.
Academic Article NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.
Academic Article Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.
Academic Article Comparative analysis of C9orf72 and sporadic disease in an ALS clinic population.
Academic Article Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity.
Academic Article ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.
Academic Article A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants.
Academic Article Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.
Academic Article Reconsidering the causality of TIA1 mutations in ALS.
Academic Article ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function.
Academic Article Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort.
Academic Article Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.
Academic Article The role of de novo mutations in the development of amyotrophic lateral sclerosis.
Academic Article Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
Academic Article Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis.
Academic Article Rare variants in MYH15 modify amyotrophic lateral sclerosis risk.
Academic Article The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing.
Academic Article Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis.
Academic Article Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology.
Academic Article CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis.
Academic Article ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization.
Academic Article Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
Academic Article The Effect of SMN Gene Dosage on ALS Risk and Disease Severity.
Academic Article Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types.
Academic Article Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway.
Academic Article Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis.
Academic Article Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
Academic Article Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis.
Academic Article Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
Academic Article ATXN2 intermediate expansions in amyotrophic lateral sclerosis.
Academic Article Telomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data.
Academic Article Amyotrophic lateral sclerosis: translating genetic discoveries into therapies.
Academic Article Genetic variability in sporadic amyotrophic lateral sclerosis.
Academic Article Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS.
Academic Article Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia.
Academic Article Mutations in the tail and rod domains of the neurofilament heavy-chain gene increase the risk of ALS.
Academic Article Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data.
Academic Article Sex-specific DNA methylation differences in Amyotrophic lateral sclerosis.
Academic Article Oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling and therapeutic implications.
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  • Motor Neuron Disease