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Academic Background

B.A. Wellesley College-Music Major, 1982
M.D. Dartmouth Medical School, 1987

Post Doctoral Training

Intern in Psychiatry, Tufts-New England Medical Center, Boston, 1987-1988

Adult Psychiatry Residency, New England Medical Center, Boston, 1988-1990

Chief Resident, Adult Psychiatry Outpatient Department, New England Medical Center, Boston, 1990-1991

Child and Adolescent Psychiatry Fellowship, Emma Pendleton, Bradley Hospital, Brown University, East Providence, Rhode Island, 1991-1993

Research Fellowship, Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, 1993-1995

Current Appointments:

2008-present Robert M. and Shirley S. Siff Chair in Autism, UMASS Medical School, Worcester, MA

2008-present Professor of Psychiatry, UMASS Medical School, Worcester, MA

2008-present Professor of Pediatrics, UMASS Medical School, Worcester, MA

2008-present Vice Chair and Director, Division of Child and Adolescent Psychiatry, UMASS Medical School, Worcester, MA

2008-present Co-Director, Child and Adolescent Neurodevelopment Initiative (CANDI), UMASS Medical School, Worcester, MA

Professional Service:

2003-presentProfessional Advisory Council for the Child and Adolescent Bipolar Foundation
Field Editor, Harvard Review of Psychiatry
2005-2008Work Group on Research, American Academy of Child and Adolescent Psychiatry
2005-presentScientific Advisory Board for Step-Up for Kids
2005-presentData Safety Monitoring Board for Stanley Early Onset Bipolar Disorder Treatment Study at University of Cincinnati:Â PI Robert Kowatch
2006-presentAssociate Editor of Psychotic Disorders: Journal of Child and Adolescent Psychopharmacology
2006-2007Committee on Integrated Research Training Programs in Child Psychiatry, American Academy of Child and Adolescent Psychiatry.
2006-presentData Safety Monitoring Board for All Clinical Trials in Child and Adolescent and Adult Psychiatry at Zucker Hillside Hospital, New York.
2006-presentÂSteering Committee of the Autism Consortium in Boston
2006-presentPsychopharmacology Experts Workgroup, Department of Mental Health, Massachusetts
2007 -2008Selection Committee for the EOP and CAP travel awards given by the American Academy of Child and Adolescent Psychiatry
2007-2009History Committee, American College of Neuropsychopharmacology
2007-presentMassachusetts Department of Mental Health Advisory Committee on Psychoactive Medication for Children and Adolescents
2007National Institute of Mental Health Review Committee ZMH 1 ERB-B 03 R- March 20th 2007
2009-presentDepartment of Mental Health-Mental Health Parity Advisory Group
2009National Institutes of Health Review Committee-NPAS- Ad Hoc Reviewer- June 2009
2009Work group Member-National Institute of Mental Health. Pediatric Bipolar Disorder Classification Meeting
2009

National Institute of Mental Health BSC-Ad hoc Reviewer June 2009

2009Autism Spectrum Clinical Trials Network Reviewer
2009-2015

Member, Neural Basis of Psychopathology, Addictions and Sleep disorders Study Section, Center for Scientific Review, National Institutes of Health

2009-2011

Credentials Committee, American College of Neuropsychopharmacology

2009Advisory Committee for Girls in Action, Girls Inc. in Worcester

Honors/Awards

2002National Alliance For The Mentally Ill- Annual Exemplary Psychiatrist Award
2003Massachusetts Psychiatric Society-Outstanding Psychiatrist Award for Research
2006Distinguished Fellow of the American Psychiatric Association
2006New England Educational Institute’s Outstanding Educator Award for Mental Health Education
2007Step up for Kids, Inc. Leadership Award
2009Best Doctors in America

Research Interests

Dr. Jean Frazier Dr. Frazier directs a broad research program that addresses a variety of scientific problems relevant to advancing the understanding, diagnosis and treatment of individuals with neurodevelopmental disorders such as early onset bipolar disorder (BPD), schizophrenia and autism. The Child and Adolescent Neurodevelopment Initiative (CANDI) team studies all three diagnostic groups since there is often overlap in the clinical symptoms, genetics, and the neuroimaging findings of these disorders and in the clinical interventions used to treat them. Research with each diagnostic group of children informs the work done with the other diagnostic groups. For example, children with autism can have mood dysregulation when asked to shift activities and a significant subset can suffer from a comorbid bipolar disorder or depressive disorder.Children with schizophrenia can also look like they have bipolar disorder with psychotic features and figuring out the diagnostic boundaries can be challenging. By studying all three groups of children, Dr. Frazier hopes to find biomarkers that might be specific to each diagnosis. In addition, she hopes to find biomarkers that may be less specific to diagnosis but more pertinent to disorders of neurodevelopment in general. The overarching goal is for Dr. Frazier's research efforts to lead to improved care of children and families affected by these disorders.

CANDI is involved in a variety of research pursuits including genetic studies, intervention studies and neuroimaging efforts. Dr. Frazier collaborates with a number of investigators both locally and nationally in order to tackle difficult questions. The neuroimaging studies use technologies such as magnetic resonance imaging (MRI) to investigate the development of brain structure and function. Using these techniques Dr. Frazier's team hopes to characterize normal development and advance the understanding of issues surrounding mental illness and atypical development and their interventions.


One or more keywords matched the following items that are connected to Frazier, Jean

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Academic Article Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment.
Academic Article Childhood-onset schizophrenia. A double-blind clozapine-haloperidol comparison.
Academic Article Temporal lobe morphology in childhood-onset schizophrenia.
Academic Article Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia.
Academic Article Brain anatomic magnetic resonance imaging in childhood-onset schizophrenia.
Academic Article "Multidimensionally impaired disorder": is it a variant of very early-onset schizophrenia?
Academic Article The influence of extended-year schooling on growth of achievement and perceived competence in early elementary school.
Academic Article Risperidone treatment for juvenile bipolar disorder: a retrospective chart review.
Academic Article Distinguishing illness severity from tic severity in children and adolescents with Tourette's disorder.
Academic Article Smooth pursuit eye movements in childhood-onset schizophrenia: comparison with attention-deficit hyperactivity disorder and normal controls.
Academic Article Blink rate in childhood-onset schizophrenia: comparison with normal and attention-deficit hyperactivity disorder controls.
Academic Article Childhood-onset schizophrenia: biological markers in relation to clinical characteristics.
Academic Article Cerebrospinal fluid monoamine metabolites in childhood-onset schizophrenia.
Academic Article Pubertal development and onset of psychosis in childhood onset schizophrenia.
Academic Article Autonomic nervous system markers of psychopathology in childhood-onset schizophrenia.
Academic Article Cerebral glucose metabolism in childhood onset schizophrenia.
Academic Article Attention deficits in childhood-onset schizophrenia: reaction time studies.
Academic Article Childhood-onset schizophrenia: an open-label study of olanzapine in adolescents.
Academic Article DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls.
Academic Article Emerging brain-based interventions for children and adolescents: overview and clinical perspective.
Academic Article Diagnostic and treatment issues in childhood-onset bipolar disorder.
Academic Article Risperidone-induced psychosis and depression in a child with a mitochondrial disorder.
Academic Article Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder.
Academic Article Empirical evidence for the use of lithium and anticonvulsants in children with psychiatric disorders.
Academic Article Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex.
Academic Article Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder.
Academic Article Treatment of early-onset schizophrenia spectrum disorders (TEOSS): rationale, design, and methods.
Academic Article Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia.
Academic Article Child psychiatry: addressing emerging clinical challenges. Introduction.
Academic Article The Collaborative Lithium Trials (CoLT): specific aims, methods, and implementation.
Academic Article Neurobiology of pediatric mood disorders: are we there yet?
Academic Article Subcortical differences among youths with attention-deficit/hyperactivity disorder compared to those with bipolar disorder with and without attention-deficit/hyperactivity disorder.
Academic Article A prospective open-label treatment trial of olanzapine monotherapy in children and adolescents with bipolar disorder.
Academic Article Magnetic resonance imaging studies in early onset bipolar disorder: an updated review.
Academic Article Cerebellum, language, and cognition in autism and specific language impairment.
Academic Article Treating a child with Asperger's disorder and comorbid bipolar disorder.
Academic Article Neurocognition in early-onset schizophrenia and schizoaffective disorders.
Academic Article Attention-deficit/hyperactivity disorder in children and adolescents with obsessive-compulsive disorder: fact or artifact?
Academic Article Clinical genetic testing for patients with autism spectrum disorders.
Academic Article Combined diffusion tensor imaging and transverse relaxometry in early-onset bipolar disorder.
Academic Article Dosing strategies for lithium monotherapy in children and adolescents with bipolar I disorder.
Academic Article Statistical adjustments for brain size in volumetric neuroimaging studies: some practical implications in methods.
Academic Article Phenomenology of prepubertal and early adolescent bipolar disorder: examples of elated mood, grandiose behaviors, decreased need for sleep, racing thoughts and hypersexuality.
Academic Article The internet brain volume database: a public resource for storage and retrieval of volumetric data.
Academic Article CANDIShare: a resource for pediatric neuroimaging data.
Academic Article Neuroanatomical assessment of biological maturity.
Academic Article An open-label trial of divalproex in children and adolescents with bipolar disorder.
Academic Article Clozapine pharmacokinetics in children and adolescents with childhood-onset schizophrenia.
Academic Article Bioenergetic measurements in children with bipolar disorder: a pilot 31P magnetic resonance spectroscopy study.
Academic Article Areas of the brain modulated by single-dose methylphenidate treatment in youth with ADHD during task-based fMRI: a systematic review.
Academic Article "Autism-plus" spectrum disorders: intersection with psychosis and the schizophrenia spectrum.
Academic Article Temperament and character factors in a prepubertal and early adolescent bipolar disorder phenotype compared to attention deficit hyperactive and normal controls.
Academic Article Childhood-onset schizophrenia: an NIMH study in progress.
Academic Article Language-association cortex asymmetry in autism and specific language impairment.
Academic Article Emerging interventions.
Academic Article Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder.
Academic Article Children with a prepubertal and early adolescent bipolar disorder phenotype from pediatric versus psychiatric facilities.
Academic Article Diagnostically homeless and needing appropriate placement.
Academic Article From zero to a hundred in a split second: understanding aggression in an eight-year-old child.
Academic Article Integrating treatment and education for mood disorders: an adolescent case report.
Academic Article Is there a role for clozapine in the treatment of children and adolescents?
Academic Article Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics.
Academic Article White matter abnormalities in children with and at risk for bipolar disorder.
Academic Article Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study.
Academic Article Neurobiology of pediatric mood disorders: Part II.
Academic Article Metformin for weight control in pediatric patients on atypical antipsychotic medication.
Academic Article Double-blind maintenance safety and effectiveness findings from the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) study.
Academic Article First-dose pharmacokinetics of lithium carbonate in children and adolescents.
Academic Article Age-related changes in the corpus callosum in early-onset bipolar disorder assessed using volumetric and cross-sectional measurements.
Academic Article Neurocognitive outcomes in the Treatment of Early-Onset Schizophrenia Spectrum Disorders study.
Academic Article Empirical evidence for psychopharmacologic treatment in early-onset psychosis and schizophrenia.
Academic Article Post-acute effectiveness of lithium in pediatric bipolar I disorder.
Academic Article Childhood trauma and psychosis.
Academic Article Psychotic disorders in youth: diagnostic and treatment challenges.
Academic Article Childhood-onset schizophrenia: the severity of premorbid course.
Academic Article Plasma clozapine and haloperidol concentrations in adolescents with childhood-onset schizophrenia: association with response.
Academic Article An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia.
Concept Child Reactive Disorders
Concept Child Behavior
Concept Child Abuse
Concept Child Development
Concept Child, Preschool
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Concept Child Psychiatry
Concept Child Behavior Disorders
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Academic Article The NIH Toolbox Cognition Battery: results from a large normative developmental sample (PING).
Academic Article Childhood maltreatment, emotional dysregulation, and psychiatric comorbidities.
Academic Article Structure-centered portal for child psychiatry research.
Academic Article Aripiprazole decreases irritability in 12 out of 14 youth with autism spectrum disorders.
Academic Article Family income, parental education and brain structure in children and adolescents.
Academic Article Relationship among Glutamine, ?-Aminobutyric Acid, and Social Cognition in Autism Spectrum Disorders.
Academic Article Vitamin D3 Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders.
Academic Article Antecedents of the child behavior checklist-dysregulation profile in children born extremely preterm.
Academic Article Lithium in the Acute Treatment of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Study.
Academic Article The Pediatric Imaging, Neurocognition, and Genetics (PING) Data Repository.
Academic Article Prenatal Triptan Exposure and Internalising and Externalising Behaviour Problems in 3-Year-Old Children: Results from the Norwegian Mother and Child Cohort Study.
Academic Article Anxiety is related to indices of cortical maturation in typically developing children and adolescents.
Academic Article Gray matter maturation and cognition in children with different APOE e genotypes.
Academic Article Longitudinal changes in neurodevelopmental outcomes between 18 and 36 months in children with prenatal triptan exposure: findings from the Norwegian Mother and Child Cohort Study.
Academic Article Circulating Inflammatory-Associated Proteins in the First Month of Life and Cognitive Impairment at Age 10 Years in Children Born Extremely Preterm.
Academic Article Extremely low gestational age and very low birthweight for gestational age are risk factors for autism spectrum disorder in a large cohort study of 10-year-old children born at 23-27 weeks' gestation.
Academic Article Simply the Best: Honoring the Outgoing Editorial Team.
Academic Article Conflict of Interest and the Journal Revisited.
Academic Article Assessing Positive Child Health among Individuals Born Extremely Preterm.
Academic Article Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm.
Academic Article Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm.
Academic Article Bias, the Scientific Method, and the Journal.
Academic Article Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age.
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Academic Article Association of Circulating Proinflammatory and Anti-inflammatory Protein Biomarkers in Extremely Preterm Born Children with Subsequent Brain Magnetic Resonance Imaging Volumes and Cognitive Function at Age 10 Years.
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