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Brown, Robert
One or more keywords matched the following items that are connected to Brown, Robert
Item TypeName
Academic Article Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS.
Academic Article The distinct genetic pattern of ALS in Turkey and novel mutations.
Academic Article Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice.
Academic Article Decoding ALS: from genes to mechanism.
Academic Article Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis.
Academic Article A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.
Academic Article Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis.
Academic Article Prospective natural history study of C9orf72 ALS clinical characteristics and biomarkers.
Academic Article Longitudinal biomarkers in amyotrophic lateral sclerosis.
Academic Article Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models.
Academic Article BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model.
Academic Article Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide.
Concept C9orf72 Protein
Academic Article Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons.
Academic Article Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD.
Academic Article CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.
Academic Article Approaches to Gene Modulation Therapy for ALS.
Academic Article Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice.
Academic Article Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptide repeat proteins in vivo.
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  • C9orf72 Protein