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Brown, Robert

One or more keywords matched the following items that are connected to Brown, Robert

Item Type	Name
Academic Article	Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.
Concept	Frontotemporal Dementia
Academic Article	Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice.
Academic Article	CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.
Academic Article	Decoding ALS: from genes to mechanism.
Academic Article	Genetics of Amyotrophic Lateral Sclerosis.
Academic Article	A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.
Academic Article	BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model.
Academic Article	Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons.
Academic Article	Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD.

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Frontotemporal Dementia