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Harlan, David
One or more keywords matched the following properties of Harlan, David
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EDUCATION

  • Medical School, Duke University School of Medicine, Durham, North Carolina
  • Residency in Medicine, Duke University Medical Center, Durham, North Carolina
  • Fellowship in Endocrinology, Duke University Medical Center, Durham, NC

ACADEMIC ROLE, FACULTY APPOINTMENT, CLINICAL ROLE

  • Chief, Diabetes, UMass Memorial Medical Center
  • Co-Director, Diabetes Center of Excellence, UMass Memorial Medical Center
  • Professor of Medicine, University of Massachusetts Medical School

RESEARCH INTERESTS

  • Tolerance mechanisms and organ/tissue transplantation
  • Autoimmune illnesses, especially insulin dependent diabetes mellitus
  • Human beta cell biology
  • Improving diabetes care delivery systems

 
One or more keywords matched the following items that are connected to Harlan, David
Item TypeName
Academic Article Protection against lethal toxic shock by targeted disruption of the CD28 gene.
Academic Article Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts.
Academic Article CD28 co-receptor signal transduction in T-cell activation.
Academic Article Phorbol esters induce differentiation of human CD34+ hemopoietic progenitors to dendritic cells: evidence for protein kinase C-mediated signaling.
Academic Article Low dose poly I:C prevents diabetes in the diabetes prone BB rat.
Academic Article CTLA4 (CD152) modulates the Th subset response and alters the course of experimental Leishmania major infection.
Academic Article Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model.
Academic Article Susceptibility or resistance to Leishmania infection is dictated by the macrophages evolved under the influence of IL-3 or GM-CSF.
Academic Article Toxic shock syndrome toxin-1-induced death is prevented by CTLA4Ig.
Academic Article Costimulatory molecules are active in the human xenoreactive T-cell response but not in natural killer-mediated cytotoxicity.
Academic Article Preincubation with endothelial cell monolayers increases gene transfer efficiency into human bone marrow CD34(+)CD38(-) progenitor cells.
Academic Article Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent.
Academic Article Effects of dose and duration of anti-CD154 antibody therapy in preventing renal allograft rejection in a nonhuman primate model.
Academic Article Primate skin allotransplantation with anti-CD154 monotherapy.
Academic Article Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates.
Academic Article Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6.
Academic Article Transplantation tolerance.
Academic Article CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.
Academic Article Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4.
Academic Article Preclinical evaluation of tolerance induction protocols and islet transplantation in non-human primates.
Academic Article Rescue of hematopoietic stem cells following high-dose radiation injury using ex vivo culture on endothelial monolayers.
Academic Article Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus.
Academic Article A proinsulin gene splice variant with increased translation efficiency is expressed in human pancreatic islets.
Academic Article Ethnicity greatly influences cytokine gene polymorphism distribution.
Academic Article Ex vivo culture with human brain endothelial cells increases the SCID-repopulating capacity of adult human bone marrow.
Academic Article Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy.
Academic Article Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation.
Academic Article Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model.
Academic Article Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H).
Academic Article Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.
Academic Article Sirolimus-induced interstitial pneumonitis in an islet transplant recipient.
Academic Article Peak stimulated insulin secretion is associated with specific changes in gene expression profiles in sporadic insulinomas.
Academic Article Induction of diabetes in nonhuman primates by means of temporary arterial embolization and selective arterial injection of streptozotocin.
Academic Article Gene-altered islets for transplant: giant leap or small step?
Academic Article Resistin serum levels in type 1 diabetes pre- and post-islet transplantation.
Academic Article Islet transplantation as a treatment for diabetes.
Academic Article Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand.
Academic Article Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates.
Academic Article Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.
Academic Article Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.
Academic Article The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge.
Academic Article Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus.
Academic Article Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance.
Academic Article The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection?
Academic Article A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.
Academic Article Immune intervention with anti-CD3 in diabetes.
Academic Article CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis.
Academic Article Assessment of islet function following islet and pancreas transplantation.
Academic Article T cell-directed therapies: lessons learned and future prospects.
Academic Article Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.
Academic Article Cytotoxic T cell-mediated diabetes in RIP-CD80 transgenic mice: autoantigen peptide sensitivity and fine specificity.
Academic Article The role of CD154 in organ transplant rejection and acceptance.
Academic Article Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function.
Academic Article Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice.
Academic Article Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations.
Academic Article Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft.
Academic Article Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.
Academic Article Effect of ingested interferon-alpha on beta-cell function in children with new-onset type 1 diabetes.
Academic Article Counterpoint: clinical islet transplantation: not ready for prime time.
Academic Article Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes.
Academic Article Current advances and travails in islet transplantation.
Academic Article Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates.
Academic Article Human platelets activate porcine endothelial cells through a CD154-dependent pathway.
Academic Article Diabetes and cancer: a consensus report.
Academic Article Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating.
Academic Article Immunological concerns with bioengineering approaches.
Academic Article Islet cell allotransplantation as a model system for a bioengineering approach to reparative medicine: immunological concerns.
Academic Article Immune response to engineered tissues and cells: breakout session summary.
Academic Article Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site.
Academic Article Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model.
Academic Article Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway.
Academic Article Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates.
Academic Article Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation.
Academic Article Histopathological study of intrahepatic islets transplanted in the nonhuman primate model using edmonton protocol immunosuppression.
Academic Article Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation.
Academic Article Beta cell-specific CD80 (B7-1) expression disrupts tissue protection from autoantigen-specific CTL-mediated diabetes.
Academic Article Islet transplantation: where do we stand now?
Academic Article Resistin is expressed in pancreatic islets.
Academic Article Effects of combined treatment with CD25- and CD154-specific monoclonal antibodies in non-human primate allotransplantation.
Academic Article State of the art: islet transplantation for the cure of type 1 diabetes mellitus.
Academic Article Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience.
Academic Article Survival after pancreas transplantation in patients with diabetes and preserved kidney function.
Academic Article Insulin secretion in type 1 diabetes.
Academic Article The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization.
Academic Article Very-low-dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic mice.
Academic Article Insulinomas and expression of an insulin splice variant.
Academic Article Pulmonary angiography for the diagnosis of thromboembolic events in the non-human primate.
Academic Article Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging.
Academic Article Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established.
Academic Article A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.
Academic Article Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy.
Academic Article Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance.
Academic Article Islet neogenesis associated protein transgenic mice are resistant to hyperglycemia induced by streptozotocin.
Academic Article Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes.
Academic Article Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes.
Academic Article Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection.
Academic Article Diabetes and cancer: a consensus report.
Academic Article Infant formula, autoimmune triggers, and type 1 diabetes.
Academic Article Comment on: Keenan et al. (2010) residual insulin production and pancreatic ?-Cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes 2010;59:2846-2853.
Academic Article Uncoupling intensive insulin therapy from weight gain and hypoglycemia in type 1 diabetes.
Academic Article Metabolic function of a suboptimal transplanted islet mass in nonhuman primates on rapamycin monotherapy.
Academic Article The Clinical Center's blood glucose management service: a story in quality integrated care.
Academic Article Humanized mice for the study of type 1 and type 2 diabetes.
Academic Article Extrapancreatic autoantibody profiles in type I diabetes.
Academic Article Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.
Concept Drug Administration Schedule
Concept Staphylococcus aureus
Concept Subcellular Fractions
Concept RNA, Small Interfering
Concept Health Services Accessibility
Concept Sequence Analysis, RNA
Concept Hematopoietic Stem Cell Transplantation
Concept Safety
Concept Cross-Over Studies
Concept Streptozocin
Concept Sampling Studies
Concept Pregnancy Trimester, Second
Concept Immune System Diseases
Concept Cell Survival
Concept Glucagon-Secreting Cells
Concept Insulin Infusion Systems
Concept Sirolimus
Concept Feasibility Studies
Concept Disease Susceptibility
Concept Freund's Adjuvant
Concept Amino Acid Sequence
Concept Cohort Studies
Concept L-Selectin
Concept T-Lymphocyte Subsets
Concept Medical Records Systems, Computerized
Concept S100 Proteins
Concept Intracellular Signaling Peptides and Proteins
Concept Statistics, Nonparametric
Concept Sulfonylurea Compounds
Concept Intercellular Signaling Peptides and Proteins
Concept Organ Specificity
Concept Retrospective Studies
Concept Insulin-Secreting Cells
Concept Organ Size
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Concept Cell Separation
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Concept Self Efficacy
Concept Granulocyte-Macrophage Colony-Stimulating Factor
Concept Skin Transplantation
Concept Blood Glucose Self-Monitoring
Concept Drug Synergism
Concept Signal Transduction
Concept P-Selectin
Concept Nucleic Acid Conformation
Concept Intestine, Small
Concept Severity of Illness Index
Concept Hematopoietic Stem Cells
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Concept Smoking
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Concept Major Histocompatibility Complex
Concept Somatostatin-Secreting Cells
Concept Glycogen Synthase Kinase 3
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Concept Smad3 Protein
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Concept Gene Library
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Concept In Situ Hybridization
Concept Genome-Wide Association Study
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Concept Alternative Splicing
Concept Surveys and Questionnaires
Concept Graft Survival
Concept Oligonucleotide Array Sequence Analysis
Concept Pluripotent Stem Cells
Concept Shock, Septic
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Concept Antilymphocyte Serum
Concept United States
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Concept Autonomic Nervous System Diseases
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Concept Von Hippel-Lindau Tumor Suppressor Protein
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Concept Hypoxia-Inducible Factor 1, alpha Subunit
Academic Article Differences in the management of type 1 diabetes among adults under excellent control compared with those under poor control in the T1D Exchange Clinic Registry.
Academic Article Diabetes: 8 strategies to put into practice.
Academic Article Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes.
Academic Article Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2r?(null) mice treated with alogliptin.
Academic Article IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse.
Academic Article Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes.
Academic Article The pancreatic ?-cell transcriptome and integrated-omics.
Academic Article Response to comment on Sarkar et al. Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes. Diabetes care 2014;37:666-670.
Academic Article Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.
Academic Article Novel Observations from Next Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets
Academic Article Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.
Academic Article Long-term immunosuppression after solitary islet transplantation is associated with preserved C-peptide secretion for more than a decade.
Academic Article The MAFB transcription factor impacts islet a-cell function in rodents and represents a unique signature of primate islet ?-cells.
Academic Article Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?.
Academic Article Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates.
Academic Article Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.
Academic Article Corrigendum: Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates.
Academic Article Islet Transplantation for Hypoglycemia Unawareness/Severe Hypoglycemia: Caveat Emptor.
Academic Article End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data.
Academic Article Redesigning Diabetes Care: Defining the Role of Endocrinologists Among Alternative Providers.
Academic Article Surprising Heterogeneity of Pancreatic Islet Cell Subsets.
Academic Article Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Academic Article Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: a multicentre randomised crossover trial.
Academic Article The upside down world of diabetes care medical economics and what we might do to improve it.
Academic Article Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Academic Article Exenatide Improves HDL Particle Counts and Size Distribution in Patients With Long-standing Type 1 Diabetes.
Academic Article Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model.
Academic Article Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes.
Academic Article Clinical Diabetes Centers of Excellence: A Model for Future Adult Diabetes Care.
Academic Article State of Behavioral Health Integration in U.S. Diabetes Care: How Close Are We to ADA Recommendations?
Academic Article a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Academic Article Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Academic Article IMPROVING AFTER-HOURS CALLS TO ENDOCRINOLOGY FELLOWS.
Academic Article Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.
Academic Article Response to Comment on Harlan. Islet Transplantation for Hypoglycemia Unawareness/Severe Hypoglycemia: Caveat Emptor. Diabetes Care 2016;39:1072-1074.
Academic Article Human islets expressing HNF1A variant have defective ? cell transcriptional regulatory networks.
Academic Article HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet ?-Cells From Donors With Type 1 Diabetes.
Academic Article Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.
Academic Article Proteomic and Transcriptional Profiles of Human Stem Cell-Derived ? Cells Following Enteroviral Challenge.
Academic Article Decreased pancreatic acinar cell number in type 1 diabetes.
Academic Article Modeling Type 1 Diabetes In?Vitro Using Human Pluripotent Stem Cells.
Academic Article Evaluation of a Diabetes Remote Monitoring Program Facilitated by Connected Glucose Meters for Patients With Poorly Controlled Type 2 Diabetes: Randomized Crossover Trial.
Academic Article Integrated Analysis of the Pancreas and Islets Reveals Unexpected Findings in Human Male With Type 1 Diabetes.
Concept Glycogen Synthase Kinase 3 beta
Concept Self-Management
Concept Myristoylated Alanine-Rich C Kinase Substrate
Concept Single-Cell Analysis
Concept Transcriptome
Concept Endoplasmic Reticulum Stress
Concept S100 Calcium Binding Protein beta Subunit
Academic Article An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes.
Academic Article Increasing intracellular dNTP levels improves prime editing efficiency.
Academic Article Digital Health Tools and Behavioral Strategies to Increase Engagement With Diabetes Self-Management Education and Support: Design and Feasibility of DM-BOOST.
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