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Harlan, David
One or more keywords matched the following properties of Harlan, David
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overview

EDUCATION

  • Medical School, Duke University School of Medicine, Durham, North Carolina
  • Residency in Medicine, Duke University Medical Center, Durham, North Carolina
  • Fellowship in Endocrinology, Duke University Medical Center, Durham, NC

ACADEMIC ROLE, FACULTY APPOINTMENT, CLINICAL ROLE

  • Chief, Diabetes, UMass Memorial Medical Center
  • Co-Director, Diabetes Center of Excellence, UMass Memorial Medical Center
  • Professor of Medicine, University of Massachusetts Medical School

RESEARCH INTERESTS

  • Tolerance mechanisms and organ/tissue transplantation
  • Autoimmune illnesses, especially insulin dependent diabetes mellitus
  • Human beta cell biology
  • Improving diabetes care delivery systems

 
One or more keywords matched the following items that are connected to Harlan, David
Item TypeName
Academic Article Islet-infiltrating t lymphocytes in insulin-dependent diabetic patients express CD80 (B7-1) and CD86 (B7-2).
Academic Article Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent.
Academic Article Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model.
Academic Article Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.
Academic Article Peak stimulated insulin secretion is associated with specific changes in gene expression profiles in sporadic insulinomas.
Academic Article Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.
Academic Article Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus.
Academic Article Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance.
Academic Article A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.
Academic Article Immune intervention with anti-CD3 in diabetes.
Academic Article Assessment of islet function following islet and pancreas transplantation.
Academic Article Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.
Academic Article How much insulin is enough? A quantitative assessment of the transdifferentiaton potential of liver.
Academic Article Cytotoxic T cell-mediated diabetes in RIP-CD80 transgenic mice: autoantigen peptide sensitivity and fine specificity.
Academic Article Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function.
Academic Article Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice.
Academic Article Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft.
Academic Article Effect of ingested interferon-alpha on beta-cell function in children with new-onset type 1 diabetes.
Academic Article Current advances and travails in islet transplantation.
Academic Article Diabetes and cancer: a consensus report.
Academic Article Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating.
Academic Article Resistin is expressed in pancreatic islets.
Academic Article Insulin secretion in type 1 diabetes.
Academic Article Very-low-dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic mice.
Academic Article Insulinomas and expression of an insulin splice variant.
Academic Article Pancreatic islet transplantation.
Academic Article A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.
Academic Article Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy.
Academic Article Islet neogenesis associated protein transgenic mice are resistant to hyperglycemia induced by streptozotocin.
Academic Article Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes.
Academic Article Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes.
Academic Article Infant formula, autoimmune triggers, and type 1 diabetes.
Academic Article Comment on: Keenan et al. (2010) residual insulin production and pancreatic ?-Cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes 2010;59:2846-2853.
Academic Article Uncoupling intensive insulin therapy from weight gain and hypoglycemia in type 1 diabetes.
Academic Article Metabolic function of a suboptimal transplanted islet mass in nonhuman primates on rapamycin monotherapy.
Academic Article The Clinical Center's blood glucose management service: a story in quality integrated care.
Concept Insulin
Concept Insulin Infusion Systems
Concept Insulin Resistance
Concept Insulin-Secreting Cells
Concept Receptor, Insulin
Academic Article Differences in the management of type 1 diabetes among adults under excellent control compared with those under poor control in the T1D Exchange Clinic Registry.
Academic Article Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes.
Academic Article IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse.
Academic Article The pancreatic ?-cell transcriptome and integrated-omics.
Academic Article Response to comment on Sarkar et al. Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes. Diabetes care 2014;37:666-670.
Academic Article Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.
Academic Article The MAFB transcription factor impacts islet a-cell function in rodents and represents a unique signature of primate islet ?-cells.
Academic Article Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?.
Academic Article Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.
Academic Article Surprising Heterogeneity of Pancreatic Islet Cell Subsets.
Academic Article Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: a multicentre randomised crossover trial.
Academic Article a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Academic Article Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.
Academic Article Human islets expressing HNF1A variant have defective ? cell transcriptional regulatory networks.
Academic Article HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet ?-Cells From Donors With Type 1 Diabetes.
Academic Article Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.
Academic Article Decreased pancreatic acinar cell number in type 1 diabetes.
Academic Article Modeling Type 1 Diabetes In?Vitro Using Human Pluripotent Stem Cells.
Academic Article The Noble and Often Nobel Role Played by Insulin-Focused Research in Modern Medicine.
Concept Insulin, Regular, Human
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  • Insulin