Research and Professional Experience:
1976-1977 Lecturer, UCSD, La Jolla, CA
1976-1981 Assistant Research Biologist, UCSD
1981-1984 Associate Research Biologist, UCSD
1984-1989 Associate Professor of Biology in Residence, UCSD
1989-1995 Professor of Biology in Residence, UCSD
1985-1996 Member, UCSD Cancer Center, San Diego, CA
1996-2007 Director, Trudeau Institute, Saranac Lake, NY
1996-present Member, Trudeau Institute, Saranac Lake, NY
1996-2007 Edward C. Brewster Chair, Trudeau Inst., Saranac Lake, NY
1998-present Adjunct Professor, Dept of Micro, Immunol & Mol. Gen, Albany Medical College, Albany, NY
2001-present Adjunct Professor, University of Vermont College of Medicine, Burlington, VT
2003-2007 President,Trudeau Institute, Saranac Lake, NY
2008-2010 President Emeritus, Trudeau Institute
2010 Professor of Pathology, UMASS Medical School, Worcester, MA
Study Sections and Advisory Panels: Past:NIH Immunobiology Study Section (1984-1988); AIDS Basic Research Advisory Committee, NIAID (1990-1992); National Taskforce on Aging, NIA/NIAID (1994); FY1997 AIDS Planning Committee (1995); Ad Hoc Member, Board of Scientific Councilors NIAID (1995, 2000); Scientific Advisory Board, Inst. for Advanced Studies in Immunol. Aging (1996-1999); Reviewer's Reserve, NIH (1988-present); NHLBI SCOR Review in Asthma Panel (2001); Board of Scientific Councilors, National Institute of Aging (2001-2006), Arthritis Review Panel in Cellular Immunology (1996-1998); Board of Trustees, Ordway Institute, Albany, NY (2001-2005), External Advisory Committee, University of Montana COBRE (2005-2007). External Advisory Board Duke University Dept. of Immunology (2008), Current: Board of Directors La Jolla Institute of Allergy and Immunology (2004-present), Selection Committee Albany Medical Prize (2005-present), External Advisory Committee (EAC): Wistar BAA (2006-present) and Dartmouth University COBRE (2007-present). National Advisory Council on Aging 2008-2012, Scientific Advisory Board La Jolla Institute of Allergy and Immunology 2008-present, Advisory Group Aeras 2007-present, Distinguished Editorial Panel NIAID (2009), Council, NIAID (Ad Hoc, 2009)
Editorial Boards:Past: Lymphokines (1985-1988); Journal of Immunology Associate Editor (1985-1987), Section Editor (1987-1991), Primary Reviewer (1997-present); International Immunology (1988-present); Cellular Immunology (1988-present); Cell (1990-1992); Current Opinion in Immunology, issue editor (1994, 1996, 2003, 2009); Current Biology (1994), Journal of Experimental Medicine (1997-2008), Current: Deputy Editor, Journal of Immunology 2008-2012, Faculty of 1000, Section Leader (2002-present).
Meeting Organization: Workshop on T and B Cell Memory (1993, 1998); Midwinter Immunology Conference Council (1992), Midwinter Conference of Immunologists (1996); Keystone Symposium on Lymphocyte Activation (1996); International Cytokine Conference (1997); Delegate IUIS (2002-2006), Workshop on Immunity and Aging, Trudeau Institute, NY (2004); Cold Spring Harbor Vaccine Meeting (2005, 2007, 2009), Keystone Symposium on Immunological Memory (2007), FASEB Summer Conference (2008, 2010).
Community Service:American Association of Immunology: Committee on Women (1988-1994), Program Committee (1988-1994); Chair, T Cell Block for FASEB Meeting (1992-1995); Nominations Committee (Elected, 1991, 1995,1996). Publication Committee (Elected, 1994-1998).
Elected Positions: Council Member, American Association of Immunologists (1999-2006); Electorate Nominating Committee of the Section on Medical Sciences, AAAS (2004); President, American Association of Immunologists (2004).
Honors and Awards:Phi Beta Kappa, Magna Cum Laude, B.A. (1968); Sigma Xi (1972); Established Investigator, American Heart Association (1981-1986); NIH Merit Award (1995, 2005); New York State Woman of Distinction (2002); Fellow of the American Association for Advancement of Science (2007); American Association of Immunologists Lifetime Achievement Award (2010).
Our past research has focused on defining the cellular and molecular mechanisms by which CD4 T cells contribute to immunity. In particular we have 1) Defined, generated and determined the function of T cell subsets at the effector stage; 2) Studied the requirements for the generation of long-live memory CD4 T cells and their role in protection against influenza infection and 3) Analyzed the defects that develop in T cell function with aging and the causes of those defects.
Our top priorities at this time are to discover new basic cellular and molecular mechanisms that are used by memory CD4 T cells to provide effective immunity to infectious diseases and to better define the age-associated defects in CD4 T cells that contribute to poor immunity of the aged and to discover strategies to overcome those defects.