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Academic Article
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Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals.
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Academic Article
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TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation.
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Academic Article
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From naive to memory T cells.
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Academic Article
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Analysis of CD4+ T cells that provide contact-dependent bystander help to B cells.
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Academic Article
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Antigen-independent changes in naive CD4 T cells with aging.
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Academic Article
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Age-related changes in CD4 T cells of T cell receptor transgenic mice.
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Academic Article
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Transferable anergy: superantigen treatment induces CD4+ T cell tolerance that is reversible and requires CD4-CD8- cells and interferon gamma.
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Academic Article
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From naive to memory. Development and regulation of CD4+ T cell responses.
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Academic Article
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Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice.
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Academic Article
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Qualitative changes accompany memory T cell generation: faster, more effective responses at lower doses of antigen.
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Academic Article
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The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related gamma(c)-receptor binding cytokines.
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Academic Article
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Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals.
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Academic Article
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Two distinct stages in the transition from naive CD4 T cells to effectors, early antigen-dependent and late cytokine-driven expansion and differentiation.
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Academic Article
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Superantigen-induced CD4 T cell tolerance mediated by myeloid cells and IFN-gamma.
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Academic Article
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Reciprocal regulation of polarized cytokine production by effector B and T cells.
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Academic Article
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CD4(+) T cell effectors can become memory cells with high efficiency and without further division.
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Academic Article
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Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis.
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Academic Article
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Regulation of T cell subsets from naive to memory.
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Academic Article
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Induction of CD4 T cell changes in murine AIDS is dependent on costimulation and involves a dysregulation of homeostasis.
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Academic Article
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In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines.
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Academic Article
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High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines.
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Academic Article
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CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function.
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Academic Article
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Regulation of memory CD4 T cells: generation, localization and persistence.
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Academic Article
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Reliable generation and use of MHC class II:gamma2aFc multimers for the identification of antigen-specific CD4(+) T cells.
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Academic Article
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CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly.
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Academic Article
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Class II-independent generation of CD4 memory T cells from effectors.
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Academic Article
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SAP deficiency results in a striking alteration of the protein profile in activated CD4 T cells.
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Academic Article
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CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch.
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Academic Article
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Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation.
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Academic Article
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Environmental and intrinsic factors lead to antigen unresponsiveness in CD4(+) recent thymic emigrants from aged mice.
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Academic Article
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IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.
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Academic Article
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Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response.
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Academic Article
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c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival.
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Academic Article
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Impact of post-thymic cellular longevity on the development of age-associated CD4+ T cell defects.
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Academic Article
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SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation.
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Academic Article
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Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses.
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Academic Article
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Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
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Academic Article
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Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects.
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Academic Article
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Effect of age on naive CD4 responses: impact on effector generation and memory development.
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Academic Article
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Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms.
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Academic Article
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The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12.
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Academic Article
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IL-7 promotes the transition of CD4 effectors to persistent memory cells.
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Academic Article
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Generation and in vivo persistence of polarized Th1 and Th2 memory cells.
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Academic Article
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Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease.
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Academic Article
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Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo.
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Academic Article
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Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen.
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Academic Article
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Is autoimmunity good for you? The Molecular Basis of Recognition in the Immune System sponsored by the European Federation of Immunological Societies, Edinburgh, UK, September 10-12, 1990.
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Academic Article
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IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells.
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Academic Article
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TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism.
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Academic Article
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Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection.
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Academic Article
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Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines.
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Academic Article
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Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.
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Academic Article
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Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion.
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Academic Article
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Role of antigen-presenting cells in the polarized development of helper T cell subsets: evidence for differential cytokine production by Th0 cells in response to antigen presentation by B cells and macrophages.
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Concept
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Mice, Transgenic
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Academic Article
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IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo.
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Academic Article
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Virus-induced natural killer cell lysis of T cell subsets.
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Academic Article
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Influenza Vaccine-Induced CD4 Effectors Require Antigen Recognition at an Effector Checkpoint to Generate CD4 Lung Memory and Antibody Production.
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Academic Article
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CD4 Effector TCR Avidity for Peptide on APC Determines the Level of Memory Generated.
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