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Clapham, Paul

One or more keywords matched the following items that are connected to Clapham, Paul

Item Type	Name
Academic Article	Cell surface receptors, virus entry and tropism of primate lentiviruses.
Academic Article	Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.
Academic Article	Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.
Academic Article	A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection.
Academic Article	Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates.
Academic Article	CD4-independent infection of HIV and SIV: implications for envelope conformation and cell tropism in vivo.
Academic Article	Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages.
Academic Article	Use of alternate coreceptors on primary cells by two HIV-1 isolates.
Academic Article	Inhibition of CCR5-mediated infection by diverse R5 and R5X4 HIV and SIV isolates using novel small molecule inhibitors of CCR5: effects of viral diversity, target cell and receptor density.
Academic Article	Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.
Academic Article	The promise of CCR5 antagonists as new therapies for HIV-1.
Academic Article	Human immunodeficiency viruses: propagation, quantification, and storage.
Academic Article	Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies.
Academic Article	Intercompartmental recombination of HIV-1 contributes to env intrahost diversity and modulates viral tropism and sensitivity to entry inhibitors.
Academic Article	Genotypic and functional properties of early infant HIV-1 envelopes.
Concept	HIV Infections
Academic Article	Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality.
Academic Article	HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.
Academic Article	Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues.
Academic Article	No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications.

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HIV Infections